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Gene: HOXA7 |
Gene summary for HOXA7 |
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Gene information | Species | Human | Gene symbol | HOXA7 | Gene ID | 3204 |
Gene name | homeobox A7 | |
Gene Alias | ANTP | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P31268 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3204 | HOXA7 | LZE2T | Human | Esophagus | ESCC | 4.68e-07 | 6.34e-01 | 0.082 |
3204 | HOXA7 | LZE4T | Human | Esophagus | ESCC | 3.20e-12 | 3.97e-01 | 0.0811 |
3204 | HOXA7 | LZE7T | Human | Esophagus | ESCC | 1.29e-05 | 4.28e-01 | 0.0667 |
3204 | HOXA7 | LZE8T | Human | Esophagus | ESCC | 1.26e-02 | 1.26e-01 | 0.067 |
3204 | HOXA7 | LZE20T | Human | Esophagus | ESCC | 3.04e-04 | 1.68e-01 | 0.0662 |
3204 | HOXA7 | LZE22T | Human | Esophagus | ESCC | 1.17e-04 | 4.22e-01 | 0.068 |
3204 | HOXA7 | LZE24T | Human | Esophagus | ESCC | 1.96e-16 | 3.73e-01 | 0.0596 |
3204 | HOXA7 | LZE21T | Human | Esophagus | ESCC | 6.00e-05 | 3.47e-01 | 0.0655 |
3204 | HOXA7 | LZE6T | Human | Esophagus | ESCC | 2.44e-05 | 2.93e-01 | 0.0845 |
3204 | HOXA7 | P1T-E | Human | Esophagus | ESCC | 5.07e-10 | 5.22e-01 | 0.0875 |
3204 | HOXA7 | P2T-E | Human | Esophagus | ESCC | 2.52e-31 | 4.59e-01 | 0.1177 |
3204 | HOXA7 | P4T-E | Human | Esophagus | ESCC | 1.07e-38 | 9.63e-01 | 0.1323 |
3204 | HOXA7 | P5T-E | Human | Esophagus | ESCC | 1.45e-09 | 1.66e-01 | 0.1327 |
3204 | HOXA7 | P8T-E | Human | Esophagus | ESCC | 3.44e-23 | 3.88e-01 | 0.0889 |
3204 | HOXA7 | P9T-E | Human | Esophagus | ESCC | 1.94e-22 | 5.59e-01 | 0.1131 |
3204 | HOXA7 | P10T-E | Human | Esophagus | ESCC | 7.38e-51 | 8.55e-01 | 0.116 |
3204 | HOXA7 | P12T-E | Human | Esophagus | ESCC | 2.84e-37 | 7.06e-01 | 0.1122 |
3204 | HOXA7 | P15T-E | Human | Esophagus | ESCC | 1.36e-21 | 4.85e-01 | 0.1149 |
3204 | HOXA7 | P16T-E | Human | Esophagus | ESCC | 4.14e-24 | 4.99e-01 | 0.1153 |
3204 | HOXA7 | P17T-E | Human | Esophagus | ESCC | 3.24e-04 | 1.88e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00108127 | Thyroid | ATC | negative regulation of cell-substrate adhesion | 33/6293 | 68/18723 | 7.60e-03 | 2.97e-02 | 33 |
GO:0002573110 | Thyroid | ATC | myeloid leukocyte differentiation | 86/6293 | 208/18723 | 1.15e-02 | 4.11e-02 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXA7 | SNV | Missense_Mutation | novel | c.475N>T | p.Arg159Cys | p.R159C | P31268 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
HOXA7 | SNV | Missense_Mutation | c.542G>A | p.Arg181His | p.R181H | P31268 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
HOXA7 | insertion | Frame_Shift_Ins | novel | c.439_440insGGACAATTCTTCTCTCGGGCTGCCCAAGCGACAGCTGTCAG | p.Lys147ArgfsTer23 | p.K147Rfs*23 | P31268 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HOXA7 | insertion | Frame_Shift_Ins | novel | c.425_426insCGAGGGCGCCGTGCCCTCTGCCGCCGCCACT | p.Leu143GlufsTer30 | p.L143Efs*30 | P31268 | protein_coding | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HOXA7 | SNV | Missense_Mutation | rs755438662 | c.89C>T | p.Ser30Phe | p.S30F | P31268 | protein_coding | deleterious(0) | possibly_damaging(0.592) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | novel | c.589N>A | p.Ala197Thr | p.A197T | P31268 | protein_coding | tolerated(0.78) | benign(0) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | novel | c.526N>C | p.Ile176Leu | p.I176L | P31268 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | novel | c.479G>A | p.Arg160His | p.R160H | P31268 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXA7 | SNV | Missense_Mutation | c.497N>T | p.Ala166Val | p.A166V | P31268 | protein_coding | tolerated(0.08) | possibly_damaging(0.663) | TCGA-DC-6157-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HOXA7 | SNV | Missense_Mutation | c.550N>G | p.Lys184Glu | p.K184E | P31268 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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