Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/HIVEP3_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HIVEP3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/HIVEP3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HIVEP3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HIVEP3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HIVEP3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HIVEP3 | IMGOB | Colorectum | ADJ | GRAMD1B,ABCA5,LINC00278, etc. | 9.63e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HIVEP3 | IMENT | Colorectum | CRC | GRAMD1B,ABCA5,LINC00278, etc. | 6.57e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
HIVEP3 | GOB | Colorectum | CRC | GRAMD1B,ABCA5,LINC00278, etc. | 4.11e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
HIVEP3 | PLA | Endometrium | Healthy | TAF4B,POLR3C,PARD6B, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
HIVEP3 | CD8TEXINT | Endometrium | Healthy | TAF4B,POLR3C,PARD6B, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
HIVEP3 | NK | Lung | IAC | AP005482.1,SLC16A1-AS1,AC243829.2, etc. | 4.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
HIVEP3 | MEGA | Pancreas | PDAC | ARL8B,AC026202.2,DCBLD2, etc. | 5.47e-05 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PDAC/regulons_activity_in_dotplot.png) |
HIVEP3 | MSC | Pancreas | PDAC | ARL8B,AC026202.2,DCBLD2, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PDAC/regulons_activity_in_dotplot.png) |
HIVEP3 | LYMEND | Pancreas | PDAC | ARL8B,AC026202.2,DCBLD2, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PDAC/regulons_activity_in_dotplot.png) |
HIVEP3 | APCAF | Pancreas | PDAC | ARL8B,AC026202.2,DCBLD2, etc. | 2.70e-04 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PDAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIVEP3 | SNV | Missense_Mutation | rs751390922 | c.1754N>A | p.Arg585Gln | p.R585Q | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP3 | SNV | Missense_Mutation | | c.5599G>C | p.Glu1867Gln | p.E1867Q | Q5T1R4 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.965) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP3 | SNV | Missense_Mutation | | c.3122G>C | p.Arg1041Thr | p.R1041T | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP3 | SNV | Missense_Mutation | | c.2695G>C | p.Glu899Gln | p.E899Q | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP3 | SNV | Missense_Mutation | | c.1879G>A | p.Glu627Lys | p.E627K | Q5T1R4 | protein_coding | tolerated(0.15) | benign(0.078) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP3 | SNV | Missense_Mutation | novel | c.6675C>A | p.Phe2225Leu | p.F2225L | Q5T1R4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.056) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP3 | SNV | Missense_Mutation | rs560610413 | c.964G>A | p.Glu322Lys | p.E322K | Q5T1R4 | protein_coding | tolerated(0.05) | benign(0.122) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP3 | SNV | Missense_Mutation | | c.3149N>T | p.Ser1050Phe | p.S1050F | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
HIVEP3 | SNV | Missense_Mutation | | c.4310N>T | p.Ser1437Ile | p.S1437I | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AO-A0J6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
HIVEP3 | SNV | Missense_Mutation | rs377282990 | c.6232N>A | p.Glu2078Lys | p.E2078K | Q5T1R4 | protein_coding | tolerated(0.57) | benign(0.073) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |