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Gene: HDGFL3 |
Gene summary for HDGFL3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HDGFL3 | Gene ID | 50810 |
| Gene name | HDGF like 3 | |
| Gene Alias | CGI-142 | |
| Cytomap | 15q25.2 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A024R216 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 50810 | HDGFL3 | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 6.95e-01 | 0.082 |
| 50810 | HDGFL3 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 4.15e-01 | 0.0811 |
| 50810 | HDGFL3 | LZE7T | Human | Esophagus | ESCC | 5.23e-19 | 9.14e-01 | 0.0667 |
| 50810 | HDGFL3 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.89e-01 | 0.067 |
| 50810 | HDGFL3 | LZE24T | Human | Esophagus | ESCC | 1.28e-07 | 1.99e-01 | 0.0596 |
| 50810 | HDGFL3 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 3.11e-01 | 0.0845 |
| 50810 | HDGFL3 | male-WTA | Human | Thyroid | PTC | 2.53e-27 | 3.46e-01 | 0.1037 |
| 50810 | HDGFL3 | PTC01 | Human | Thyroid | PTC | 2.71e-09 | 2.47e-01 | 0.1899 |
| 50810 | HDGFL3 | PTC03 | Human | Thyroid | PTC | 3.54e-03 | 2.01e-01 | 0.1784 |
| 50810 | HDGFL3 | PTC04 | Human | Thyroid | PTC | 5.13e-22 | 3.77e-01 | 0.1927 |
| 50810 | HDGFL3 | PTC05 | Human | Thyroid | PTC | 2.38e-23 | 6.27e-01 | 0.2065 |
| 50810 | HDGFL3 | PTC06 | Human | Thyroid | PTC | 1.62e-41 | 8.25e-01 | 0.2057 |
| 50810 | HDGFL3 | PTC07 | Human | Thyroid | PTC | 2.83e-29 | 5.89e-01 | 0.2044 |
| 50810 | HDGFL3 | ATC09 | Human | Thyroid | ATC | 2.26e-06 | 2.81e-01 | 0.2871 |
| 50810 | HDGFL3 | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 8.01e-01 | 0.3386 |
| 50810 | HDGFL3 | ATC12 | Human | Thyroid | ATC | 1.72e-28 | 5.08e-01 | 0.34 |
| 50810 | HDGFL3 | ATC13 | Human | Thyroid | ATC | 4.01e-71 | 1.20e+00 | 0.34 |
| 50810 | HDGFL3 | ATC1 | Human | Thyroid | ATC | 1.52e-06 | 3.11e-01 | 0.2878 |
| 50810 | HDGFL3 | ATC2 | Human | Thyroid | ATC | 8.62e-27 | 1.40e+00 | 0.34 |
| 50810 | HDGFL3 | ATC3 | Human | Thyroid | ATC | 6.48e-06 | 5.18e-01 | 0.338 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003111012 | Thyroid | ATC | regulation of microtubule polymerization or depolymerization | 47/6293 | 88/18723 | 1.01e-04 | 7.30e-04 | 47 |
| GO:003110912 | Thyroid | ATC | microtubule polymerization or depolymerization | 61/6293 | 122/18723 | 1.30e-04 | 9.15e-04 | 61 |
| GO:0051494110 | Thyroid | ATC | negative regulation of cytoskeleton organization | 76/6293 | 163/18723 | 3.68e-04 | 2.27e-03 | 76 |
| GO:190187911 | Thyroid | ATC | regulation of protein depolymerization | 43/6293 | 87/18723 | 1.62e-03 | 8.14e-03 | 43 |
| GO:004324412 | Thyroid | ATC | regulation of protein-containing complex disassembly | 56/6293 | 121/18723 | 2.51e-03 | 1.16e-02 | 56 |
| GO:190188011 | Thyroid | ATC | negative regulation of protein depolymerization | 35/6293 | 72/18723 | 5.89e-03 | 2.37e-02 | 35 |
| GO:00311111 | Thyroid | ATC | negative regulation of microtubule polymerization or depolymerization | 21/6293 | 40/18723 | 1.05e-02 | 3.81e-02 | 21 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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