Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GRIPAP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GRIPAP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GRIPAP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GRIPAP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00988769 | Oral cavity | OSCC | vesicle-mediated transport to the plasma membrane | 79/7305 | 136/18723 | 4.93e-06 | 5.58e-05 | 79 |
GO:00619518 | Oral cavity | OSCC | establishment of protein localization to plasma membrane | 39/7305 | 60/18723 | 4.07e-05 | 3.53e-04 | 39 |
GO:1903421 | Oral cavity | OSCC | regulation of synaptic vesicle recycling | 18/7305 | 27/18723 | 3.34e-03 | 1.42e-02 | 18 |
GO:00995323 | Oral cavity | OSCC | synaptic vesicle endosomal processing | 8/7305 | 10/18723 | 1.03e-02 | 3.53e-02 | 8 |
GO:0032386111 | Thyroid | PTC | regulation of intracellular transport | 202/5968 | 337/18723 | 1.12e-26 | 3.93e-24 | 202 |
GO:0033157112 | Thyroid | PTC | regulation of intracellular protein transport | 149/5968 | 229/18723 | 3.83e-25 | 1.15e-22 | 149 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:001619718 | Thyroid | PTC | endosomal transport | 128/5968 | 230/18723 | 6.26e-14 | 3.52e-12 | 128 |
GO:1904375111 | Thyroid | PTC | regulation of protein localization to cell periphery | 70/5968 | 125/18723 | 2.04e-08 | 4.71e-07 | 70 |
GO:190547525 | Thyroid | PTC | regulation of protein localization to membrane | 91/5968 | 175/18723 | 2.41e-08 | 5.43e-07 | 91 |
GO:006195117 | Thyroid | PTC | establishment of protein localization to plasma membrane | 40/5968 | 60/18723 | 3.26e-08 | 7.20e-07 | 40 |
GO:009887618 | Thyroid | PTC | vesicle-mediated transport to the plasma membrane | 74/5968 | 136/18723 | 4.20e-08 | 9.08e-07 | 74 |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:1903076112 | Thyroid | PTC | regulation of protein localization to plasma membrane | 58/5968 | 104/18723 | 3.91e-07 | 6.51e-06 | 58 |
GO:00995637 | Thyroid | PTC | modification of synaptic structure | 16/5968 | 22/18723 | 9.98e-05 | 8.15e-04 | 16 |
GO:19052445 | Thyroid | PTC | regulation of modification of synaptic structure | 11/5968 | 13/18723 | 1.34e-04 | 1.05e-03 | 11 |
GO:00995325 | Thyroid | PTC | synaptic vesicle endosomal processing | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:19026832 | Thyroid | PTC | regulation of receptor localization to synapse | 12/5968 | 18/18723 | 2.55e-03 | 1.31e-02 | 12 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRIPAP1 | SNV | Missense_Mutation | novel | c.1667C>T | p.Ala556Val | p.A556V | Q4V328 | protein_coding | tolerated(0.18) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | | c.1888N>A | p.Glu630Lys | p.E630K | Q4V328 | protein_coding | deleterious(0.02) | benign(0.093) | TCGA-AN-A0XO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | | c.571N>A | p.Glu191Lys | p.E191K | Q4V328 | protein_coding | tolerated(0.12) | probably_damaging(0.992) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.2470N>T | p.Ser824Cys | p.S824C | Q4V328 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | | c.1067N>C | p.Leu356Pro | p.L356P | Q4V328 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | | c.1314N>A | p.Met438Ile | p.M438I | Q4V328 | protein_coding | tolerated(1) | possibly_damaging(0.871) | TCGA-D8-A1XB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRIPAP1 | SNV | Missense_Mutation | | c.1105G>A | p.Glu369Lys | p.E369K | Q4V328 | protein_coding | tolerated(0.09) | possibly_damaging(0.878) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
GRIPAP1 | SNV | Missense_Mutation | rs782656835 | c.1364G>A | p.Arg455His | p.R455H | Q4V328 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.913N>A | p.Glu305Lys | p.E305K | Q4V328 | protein_coding | tolerated(0.08) | possibly_damaging(0.885) | TCGA-LD-A7W5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
GRIPAP1 | SNV | Missense_Mutation | novel | c.125N>T | p.Arg42Leu | p.R42L | Q4V328 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |