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Gene: GLRX |
Gene summary for GLRX |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GLRX | Gene ID | 2745 |
| Gene name | glutaredoxin | |
| Gene Alias | GRX | |
| Cytomap | 5q15 | |
| Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | A0A024RAM2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2745 | GLRX | GSM4909285 | Human | Breast | IDC | 3.60e-09 | -3.02e-01 | 0.21 |
| 2745 | GLRX | GSM4909286 | Human | Breast | IDC | 4.91e-06 | -3.09e-01 | 0.1081 |
| 2745 | GLRX | GSM4909291 | Human | Breast | IDC | 1.81e-07 | -3.87e-01 | 0.1753 |
| 2745 | GLRX | GSM4909293 | Human | Breast | IDC | 2.89e-04 | -2.83e-01 | 0.1581 |
| 2745 | GLRX | GSM4909294 | Human | Breast | IDC | 1.34e-04 | -1.63e-01 | 0.2022 |
| 2745 | GLRX | GSM4909295 | Human | Breast | IDC | 3.63e-02 | -3.26e-01 | 0.0898 |
| 2745 | GLRX | GSM4909296 | Human | Breast | IDC | 1.07e-06 | -2.40e-01 | 0.1524 |
| 2745 | GLRX | GSM4909297 | Human | Breast | IDC | 9.92e-12 | -3.10e-01 | 0.1517 |
| 2745 | GLRX | GSM4909299 | Human | Breast | IDC | 3.95e-04 | -2.76e-01 | 0.035 |
| 2745 | GLRX | GSM4909301 | Human | Breast | IDC | 5.76e-06 | -2.72e-01 | 0.1577 |
| 2745 | GLRX | GSM4909302 | Human | Breast | IDC | 1.91e-12 | -3.87e-01 | 0.1545 |
| 2745 | GLRX | GSM4909304 | Human | Breast | IDC | 8.84e-15 | -3.80e-01 | 0.1636 |
| 2745 | GLRX | GSM4909306 | Human | Breast | IDC | 5.35e-09 | -3.38e-01 | 0.1564 |
| 2745 | GLRX | GSM4909307 | Human | Breast | IDC | 4.22e-10 | 5.38e-01 | 0.1569 |
| 2745 | GLRX | GSM4909308 | Human | Breast | IDC | 9.18e-40 | 8.17e-01 | 0.158 |
| 2745 | GLRX | GSM4909309 | Human | Breast | IDC | 7.19e-05 | -3.07e-01 | 0.0483 |
| 2745 | GLRX | GSM4909311 | Human | Breast | IDC | 8.57e-23 | -4.17e-01 | 0.1534 |
| 2745 | GLRX | GSM4909312 | Human | Breast | IDC | 2.96e-12 | -3.45e-01 | 0.1552 |
| 2745 | GLRX | GSM4909313 | Human | Breast | IDC | 3.96e-05 | -2.98e-01 | 0.0391 |
| 2745 | GLRX | GSM4909317 | Human | Breast | IDC | 2.64e-08 | -3.57e-01 | 0.1355 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
| GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
| GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
| GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
| GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
| GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
| GO:00974282 | Esophagus | HGIN | protein maturation by iron-sulfur cluster transfer | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
| GO:00162263 | Esophagus | HGIN | iron-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
| GO:00311633 | Esophagus | HGIN | metallo-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
| GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
| GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
| GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
| GO:0022900110 | Esophagus | ESCC | electron transport chain | 133/8552 | 175/18723 | 2.18e-16 | 1.67e-14 | 133 |
| GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
| GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
| GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
| GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
| GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
| GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GLRX | SNV | Missense_Mutation | c.224N>C | p.Ile75Thr | p.I75T | P35754 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
| GLRX | SNV | Missense_Mutation | novel | c.170N>G | p.Ile57Ser | p.I57S | P35754 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| GLRX | SNV | Missense_Mutation | rs151319399 | c.292N>T | p.Arg98Trp | p.R98W | P35754 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GLRX | SNV | Missense_Mutation | rs140804825 | c.290N>T | p.Thr97Met | p.T97M | P35754 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GLRX | SNV | Missense_Mutation | novel | c.178T>C | p.Tyr60His | p.Y60H | P35754 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
| GLRX | SNV | Missense_Mutation | novel | c.253G>T | p.Asp85Tyr | p.D85Y | P35754 | protein_coding | deleterious(0.04) | possibly_damaging(0.881) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| GLRX | SNV | Missense_Mutation | c.215N>A | p.Arg72Gln | p.R72Q | P35754 | protein_coding | tolerated(0.12) | possibly_damaging(0.598) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
| GLRX | SNV | Missense_Mutation | novel | c.232G>A | p.Asp78Asn | p.D78N | P35754 | protein_coding | tolerated(0.15) | benign(0.165) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| GLRX | SNV | Missense_Mutation | novel | c.134T>G | p.Phe45Cys | p.F45C | P35754 | protein_coding | tolerated(0.08) | benign(0.024) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
| GLRX | SNV | Missense_Mutation | c.148G>A | p.Ala50Thr | p.A50T | P35754 | protein_coding | tolerated(0.13) | benign(0.042) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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