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Gene: GGT1 |
Gene summary for GGT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GGT1 | Gene ID | 2678 |
| Gene name | gamma-glutamyltransferase 1 | |
| Gene Alias | CD224 | |
| Cytomap | 22q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A140VJJ9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2678 | GGT1 | HCC1_Meng | Human | Liver | HCC | 8.60e-96 | 5.80e-01 | 0.0246 |
| 2678 | GGT1 | HCC2_Meng | Human | Liver | HCC | 5.43e-30 | 1.99e-01 | 0.0107 |
| 2678 | GGT1 | cirrhotic3 | Human | Liver | Cirrhotic | 2.77e-02 | 1.50e-01 | 0.0215 |
| 2678 | GGT1 | HCC2 | Human | Liver | HCC | 3.76e-06 | 1.76e+00 | 0.5341 |
| 2678 | GGT1 | S014 | Human | Liver | HCC | 4.30e-23 | 1.22e+00 | 0.2254 |
| 2678 | GGT1 | S015 | Human | Liver | HCC | 9.32e-33 | 1.83e+00 | 0.2375 |
| 2678 | GGT1 | S016 | Human | Liver | HCC | 1.33e-33 | 1.48e+00 | 0.2243 |
| 2678 | GGT1 | S027 | Human | Liver | HCC | 6.84e-17 | 1.53e+00 | 0.2446 |
| 2678 | GGT1 | S028 | Human | Liver | HCC | 6.90e-40 | 1.43e+00 | 0.2503 |
| 2678 | GGT1 | S029 | Human | Liver | HCC | 5.25e-36 | 1.71e+00 | 0.2581 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004239811 | Liver | Cirrhotic | cellular modified amino acid biosynthetic process | 25/4634 | 46/18723 | 1.61e-05 | 2.19e-04 | 25 |
| GO:19016071 | Liver | Cirrhotic | alpha-amino acid biosynthetic process | 33/4634 | 68/18723 | 1.84e-05 | 2.49e-04 | 33 |
| GO:00090691 | Liver | Cirrhotic | serine family amino acid metabolic process | 22/4634 | 40/18723 | 4.04e-05 | 4.82e-04 | 22 |
| GO:00442721 | Liver | Cirrhotic | sulfur compound biosynthetic process | 58/4634 | 148/18723 | 6.93e-05 | 7.83e-04 | 58 |
| GO:000657511 | Liver | Cirrhotic | cellular modified amino acid metabolic process | 70/4634 | 188/18723 | 9.04e-05 | 9.69e-04 | 70 |
| GO:00000961 | Liver | Cirrhotic | sulfur amino acid metabolic process | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
| GO:00346126 | Liver | Cirrhotic | response to tumor necrosis factor | 89/4634 | 253/18723 | 1.24e-04 | 1.22e-03 | 89 |
| GO:0006534 | Liver | Cirrhotic | cysteine metabolic process | 9/4634 | 12/18723 | 3.59e-04 | 3.03e-03 | 9 |
| GO:00324966 | Liver | Cirrhotic | response to lipopolysaccharide | 111/4634 | 343/18723 | 8.15e-04 | 5.95e-03 | 111 |
| GO:00323551 | Liver | Cirrhotic | response to estradiol | 51/4634 | 141/18723 | 1.60e-03 | 1.04e-02 | 51 |
| GO:00067494 | Liver | Cirrhotic | glutathione metabolic process | 27/4634 | 64/18723 | 1.63e-03 | 1.05e-02 | 27 |
| GO:00022376 | Liver | Cirrhotic | response to molecule of bacterial origin | 113/4634 | 363/18723 | 3.23e-03 | 1.81e-02 | 113 |
| GO:0006750 | Liver | Cirrhotic | glutathione biosynthetic process | 9/4634 | 16/18723 | 6.94e-03 | 3.38e-02 | 9 |
| GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
| GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
| GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
| GO:003596612 | Liver | HCC | response to topologically incorrect protein | 123/7958 | 159/18723 | 2.60e-19 | 3.44e-17 | 123 |
| GO:003650311 | Liver | HCC | ERAD pathway | 88/7958 | 107/18723 | 2.87e-17 | 2.85e-15 | 88 |
| GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
| GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
| hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GGT1 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Leu | p.S28L | P19440 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
| GGT1 | SNV | Missense_Mutation | rs779028206 | c.944G>A | p.Arg315His | p.R315H | P19440 | protein_coding | deleterious(0.02) | possibly_damaging(0.532) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| GGT1 | SNV | Missense_Mutation | novel | c.1147N>T | p.His383Tyr | p.H383Y | P19440 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| GGT1 | SNV | Missense_Mutation | rs3966247 | c.1124N>T | p.Thr375Met | p.T375M | P19440 | protein_coding | tolerated(0.18) | benign(0.153) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
| GGT1 | SNV | Missense_Mutation | rs201969696 | c.1232C>T | p.Pro411Leu | p.P411L | P19440 | protein_coding | tolerated(0.34) | benign(0.052) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
| GGT1 | SNV | Missense_Mutation | rs757603351 | c.574N>C | p.Cys192Arg | p.C192R | P19440 | protein_coding | tolerated(0.5) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GGT1 | SNV | Missense_Mutation | novel | c.148N>G | p.Cys50Gly | p.C50G | P19440 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| GGT1 | SNV | Missense_Mutation | rs750317020 | c.439N>T | p.Arg147Trp | p.R147W | P19440 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| GGT1 | SNV | Missense_Mutation | rs757411384 | c.949N>A | p.Val317Ile | p.V317I | P19440 | protein_coding | tolerated(0.43) | benign(0.062) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
| GGT1 | SNV | Missense_Mutation | c.386N>A | p.Gly129Glu | p.G129E | P19440 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | ANTIBIOTICS | 2571317 | ||
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | DISULFIRAM | DISULFIRAM | 8904971 | |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | GENTAMICIN | GENTAMICIN | 15736857 | |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | ANTI-INFLAMMATORY DRUGS | 2571317 | ||
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | ETHINYL ESTRADIOL | 12312052 | ||
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | DEXAMETHASONE | DEXAMETHASONE | 2890444 | |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | URSODEOXYCHOLIC ACID | 7712308 | ||
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | PIROXICAM | PIROXICAM | 9090444 | |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | INDOMETHACIN | INDOMETHACIN | 9090444 | |
| 2678 | GGT1 | CELL SURFACE, ENZYME, PROTEASE, DRUGGABLE GENOME | MANNITOL | MANNITOL | 11471882 |
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