Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: FUT8

Gene summary for FUT8

Gene summary.

Gene information	Species	Human
	Gene symbol	FUT8
	Gene ID	2530
	Gene name	fucosyltransferase 8
	Gene Alias	CDGF
	Cytomap	14q23.3
	Gene Type	protein-coding
	GO ID	GO:0001701
	UniProtAcc	Q546E0

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Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
2530	FUT8	HTA11_1391_2000001011	Human	Colorectum	AD	2.11e-04	6.45e-01	-0.059
2530	FUT8	HTA11_99999965104_69814	Human	Colorectum	MSS	1.08e-02	4.53e-01	0.281
2530	FUT8	HTA11_99999971662_82457	Human	Colorectum	MSS	1.23e-05	-4.09e-01	0.3859
2530	FUT8	F007	Human	Colorectum	FAP	6.22e-04	3.95e-01	0.1176
2530	FUT8	A002-C-010	Human	Colorectum	FAP	3.91e-33	7.63e-01	0.242
2530	FUT8	A001-C-207	Human	Colorectum	FAP	1.80e-02	2.35e-01	0.1278
2530	FUT8	A015-C-203	Human	Colorectum	FAP	1.66e-16	-3.11e-01	-0.1294
2530	FUT8	A002-C-201	Human	Colorectum	FAP	1.07e-14	3.58e-01	0.0324
2530	FUT8	A002-C-203	Human	Colorectum	FAP	1.74e-20	6.75e-01	0.2786
2530	FUT8	A001-C-108	Human	Colorectum	FAP	1.07e-05	2.14e-01	-0.0272
2530	FUT8	A002-C-205	Human	Colorectum	FAP	4.65e-15	5.34e-02	-0.1236
2530	FUT8	A015-C-006	Human	Colorectum	FAP	9.12e-10	9.17e-03	-0.0994
2530	FUT8	A015-C-106	Human	Colorectum	FAP	1.01e-04	-1.10e-01	-0.0511
2530	FUT8	A002-C-114	Human	Colorectum	FAP	1.10e-10	-9.29e-02	-0.1561
2530	FUT8	A015-C-104	Human	Colorectum	FAP	3.28e-17	-4.13e-01	-0.1899
2530	FUT8	A001-C-014	Human	Colorectum	FAP	2.58e-05	1.59e-01	0.0135
2530	FUT8	A002-C-016	Human	Colorectum	FAP	1.93e-16	3.07e-01	0.0521
2530	FUT8	A015-C-002	Human	Colorectum	FAP	1.19e-05	-1.81e-01	-0.0763
2530	FUT8	A001-C-203	Human	Colorectum	FAP	8.53e-04	7.56e-02	-0.0481
2530	FUT8	A002-C-116	Human	Colorectum	FAP	5.61e-21	1.03e-01	-0.0452

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Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
GC		CAG: Chronic atrophic gastritis
		CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
		CSG: Chronic superficial gastritis
		GC: Gastric cancer
		SIM: Severe intestinal metaplasia
		WIM: Wild intestinal metaplasia
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

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Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:19028822	Colorectum	MSS	regulation of response to oxidative stress	31/3467	98/18723	1.22e-03	1.18e-02	31
GO:00193182	Colorectum	MSS	hexose metabolic process	63/3467	237/18723	1.32e-03	1.25e-02	63
GO:00059962	Colorectum	MSS	monosaccharide metabolic process	66/3467	257/18723	2.61e-03	2.06e-02	66
GO:00092252	Colorectum	MSS	nucleotide-sugar metabolic process	14/3467	36/18723	3.40e-03	2.56e-02	14
GO:00071781	Colorectum	MSS	transmembrane receptor protein serine/threonine kinase signaling pathway	86/3467	355/18723	4.04e-03	2.95e-02	86
GO:00160324	Colorectum	FAP	viral process	114/2622	415/18723	3.00e-13	2.63e-10	114
GO:00621974	Colorectum	FAP	cellular response to chemical stress	83/2622	337/18723	1.15e-07	7.43e-06	83
GO:00069794	Colorectum	FAP	response to oxidative stress	102/2622	446/18723	2.29e-07	1.33e-05	102
GO:00160523	Colorectum	FAP	carbohydrate catabolic process	44/2622	154/18723	1.82e-06	7.42e-05	44
GO:00431122	Colorectum	FAP	receptor metabolic process	46/2622	166/18723	2.70e-06	1.02e-04	46
GO:00345994	Colorectum	FAP	cellular response to oxidative stress	69/2622	288/18723	3.72e-06	1.29e-04	69
GO:00715591	Colorectum	FAP	response to transforming growth factor beta	63/2622	256/18723	3.82e-06	1.32e-04	63
GO:00071782	Colorectum	FAP	transmembrane receptor protein serine/threonine kinase signaling pathway	81/2622	355/18723	4.28e-06	1.46e-04	81
GO:00715601	Colorectum	FAP	cellular response to transforming growth factor beta stimulus	61/2622	250/18723	7.22e-06	2.19e-04	61
GO:00193183	Colorectum	FAP	hexose metabolic process	58/2622	237/18723	1.09e-05	3.08e-04	58
GO:00017013	Colorectum	FAP	in utero embryonic development	81/2622	367/18723	1.58e-05	4.10e-04	81
GO:00071791	Colorectum	FAP	transforming growth factor beta receptor signaling pathway	50/2622	198/18723	1.75e-05	4.44e-04	50
GO:00190804	Colorectum	FAP	viral gene expression	29/2622	94/18723	2.07e-05	5.05e-04	29
GO:00059963	Colorectum	FAP	monosaccharide metabolic process	59/2622	257/18723	6.79e-05	1.28e-03	59
GO:00193201	Colorectum	FAP	hexose catabolic process	14/2622	34/18723	9.46e-05	1.61e-03	14

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Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa00510	Colorectum	AD	N-Glycan biosynthesis	21/2092	53/8465	1.15e-02	4.24e-02	2.71e-02	21
hsa005101	Colorectum	AD	N-Glycan biosynthesis	21/2092	53/8465	1.15e-02	4.24e-02	2.71e-02	21
hsa005102	Colorectum	MSS	N-Glycan biosynthesis	20/1875	53/8465	7.17e-03	2.83e-02	1.73e-02	20
hsa00513	Colorectum	MSS	Various types of N-glycan biosynthesis	16/1875	42/8465	1.39e-02	4.53e-02	2.77e-02	16
hsa005103	Colorectum	MSS	N-Glycan biosynthesis	20/1875	53/8465	7.17e-03	2.83e-02	1.73e-02	20
hsa005131	Colorectum	MSS	Various types of N-glycan biosynthesis	16/1875	42/8465	1.39e-02	4.53e-02	2.77e-02	16
hsa05202	Colorectum	FAP	Transcriptional misregulation in cancer	45/1404	193/8465	9.19e-03	3.33e-02	2.03e-02	45
hsa052021	Colorectum	FAP	Transcriptional misregulation in cancer	45/1404	193/8465	9.19e-03	3.33e-02	2.03e-02	45
hsa0051023	Esophagus	ESCC	N-Glycan biosynthesis	39/4205	53/8465	3.26e-04	1.15e-03	5.89e-04	39
hsa005136	Esophagus	ESCC	Various types of N-glycan biosynthesis	31/4205	42/8465	1.23e-03	3.78e-03	1.93e-03	31
hsa052028	Esophagus	ESCC	Transcriptional misregulation in cancer	116/4205	193/8465	2.08e-03	5.95e-03	3.05e-03	116
hsa0051033	Esophagus	ESCC	N-Glycan biosynthesis	39/4205	53/8465	3.26e-04	1.15e-03	5.89e-04	39
hsa0051313	Esophagus	ESCC	Various types of N-glycan biosynthesis	31/4205	42/8465	1.23e-03	3.78e-03	1.93e-03	31
hsa0520213	Esophagus	ESCC	Transcriptional misregulation in cancer	116/4205	193/8465	2.08e-03	5.95e-03	3.05e-03	116
hsa052026	Lung	IAC	Transcriptional misregulation in cancer	40/1053	193/8465	6.90e-04	5.90e-03	3.92e-03	40
hsa0520211	Lung	IAC	Transcriptional misregulation in cancer	40/1053	193/8465	6.90e-04	5.90e-03	3.92e-03	40
hsa052022	Lung	AIS	Transcriptional misregulation in cancer	39/961	193/8465	2.15e-04	2.41e-03	1.54e-03	39
hsa052023	Lung	AIS	Transcriptional misregulation in cancer	39/961	193/8465	2.15e-04	2.41e-03	1.54e-03	39
hsa052024	Lung	MIAC	Transcriptional misregulation in cancer	22/507	193/8465	2.64e-03	2.26e-02	1.64e-02	22
hsa052025	Lung	MIAC	Transcriptional misregulation in cancer	22/507	193/8465	2.64e-03	2.26e-02	1.64e-02	22

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Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

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Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

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Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

FUT8

SNV

Missense_Mutation

c.109N>A

p.Asp37Asn

p.D37N

Q9BYC5

protein_coding

tolerated(0.08)

benign(0.12)

TCGA-A2-A0YK-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

FUT8

SNV

Missense_Mutation

novel

c.601N>A

p.Pro201Thr

p.P201T

Q9BYC5

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

FUT8

SNV

Missense_Mutation

novel

c.824N>C

p.Gly275Ala

p.G275A

Q9BYC5

protein_coding

tolerated(1)

benign(0.271)

TCGA-BH-A2L8-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

FUT8

insertion

Nonsense_Mutation

novel

c.1184_1185insATTCTAAGTGTTAGACGTAAAGAAGGTACATGTGAAGT

p.Arg396PhefsTer2

p.R396Ffs*2

Q9BYC5

protein_coding

TCGA-A2-A0EM-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

tamoxiphen

FUT8

SNV

Missense_Mutation

novel

c.643N>G

p.Asn215Asp

p.N215D

Q9BYC5

protein_coding

deleterious(0.01)

possibly_damaging(0.812)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

FUT8

SNV

Missense_Mutation

novel

c.1097N>A

p.Arg366His

p.R366H

Q9BYC5

protein_coding

deleterious(0)

probably_damaging(0.994)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

FUT8

SNV

Missense_Mutation

novel

c.1673N>C

p.Val558Ala

p.V558A

Q9BYC5

protein_coding

tolerated(0.2)

probably_damaging(0.994)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

FUT8

SNV

Missense_Mutation

c.1033N>C

p.Glu345Gln

p.E345Q

Q9BYC5

protein_coding

tolerated(0.32)

benign(0.307)

TCGA-Q1-A73O-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

FUT8

SNV

Missense_Mutation

rs765246656

c.1720G>A

p.Glu574Lys

p.E574K

Q9BYC5

protein_coding

tolerated(0.43)

benign(0.027)

TCGA-VS-A958-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

FUT8

insertion

Frame_Shift_Ins

novel

c.1200_1201insA

p.Arg403LysfsTer8

p.R403Kfs*8

Q9BYC5

protein_coding

TCGA-IR-A3LC-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unspecific

Cisplatin

Complete Response

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Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

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