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Gene: FECH |
Gene summary for FECH |
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Gene information | Species | Human | Gene symbol | FECH | Gene ID | 2235 |
Gene name | ferrochelatase | |
Gene Alias | EPP | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P22830 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2235 | FECH | LZE4T | Human | Esophagus | ESCC | 1.89e-09 | 2.56e-01 | 0.0811 |
2235 | FECH | LZE7T | Human | Esophagus | ESCC | 4.35e-04 | 2.50e-01 | 0.0667 |
2235 | FECH | LZE24T | Human | Esophagus | ESCC | 6.93e-09 | 1.58e-01 | 0.0596 |
2235 | FECH | P2T-E | Human | Esophagus | ESCC | 9.30e-13 | 2.18e-01 | 0.1177 |
2235 | FECH | P4T-E | Human | Esophagus | ESCC | 1.12e-12 | 2.94e-01 | 0.1323 |
2235 | FECH | P5T-E | Human | Esophagus | ESCC | 1.46e-03 | 5.99e-02 | 0.1327 |
2235 | FECH | P8T-E | Human | Esophagus | ESCC | 2.15e-02 | 8.14e-02 | 0.0889 |
2235 | FECH | P9T-E | Human | Esophagus | ESCC | 1.60e-11 | 1.55e-01 | 0.1131 |
2235 | FECH | P10T-E | Human | Esophagus | ESCC | 3.12e-05 | 1.01e-01 | 0.116 |
2235 | FECH | P11T-E | Human | Esophagus | ESCC | 5.35e-03 | 1.44e-01 | 0.1426 |
2235 | FECH | P12T-E | Human | Esophagus | ESCC | 5.52e-12 | 1.89e-01 | 0.1122 |
2235 | FECH | P15T-E | Human | Esophagus | ESCC | 1.71e-07 | 1.75e-01 | 0.1149 |
2235 | FECH | P16T-E | Human | Esophagus | ESCC | 1.27e-10 | 1.87e-01 | 0.1153 |
2235 | FECH | P17T-E | Human | Esophagus | ESCC | 8.76e-06 | 2.05e-01 | 0.1278 |
2235 | FECH | P20T-E | Human | Esophagus | ESCC | 1.11e-07 | 1.32e-01 | 0.1124 |
2235 | FECH | P21T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.66e-01 | 0.1617 |
2235 | FECH | P22T-E | Human | Esophagus | ESCC | 3.27e-08 | 1.88e-01 | 0.1236 |
2235 | FECH | P23T-E | Human | Esophagus | ESCC | 4.95e-04 | 1.22e-01 | 0.108 |
2235 | FECH | P24T-E | Human | Esophagus | ESCC | 1.67e-07 | 1.55e-01 | 0.1287 |
2235 | FECH | P26T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.68e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016552 | Liver | HCC | cellular response to ketone | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
GO:00067781 | Liver | HCC | porphyrin-containing compound metabolic process | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:0042440 | Liver | HCC | pigment metabolic process | 51/7958 | 84/18723 | 5.74e-04 | 3.65e-03 | 51 |
GO:00102881 | Liver | HCC | response to lead ion | 18/7958 | 24/18723 | 1.27e-03 | 6.92e-03 | 18 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:0006783 | Liver | HCC | heme biosynthetic process | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:0006779 | Liver | HCC | porphyrin-containing compound biosynthetic process | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
GO:0033014 | Liver | HCC | tetrapyrrole biosynthetic process | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
GO:0046148 | Liver | HCC | pigment biosynthetic process | 37/7958 | 62/18723 | 4.73e-03 | 2.02e-02 | 37 |
GO:00454712 | Liver | HCC | response to ethanol | 72/7958 | 137/18723 | 1.10e-02 | 4.07e-02 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FECH | insertion | Frame_Shift_Ins | novel | c.1029_1030insGTAACTGACTTTTATATGAAGTTTGAGAATACAGCCTCTTCAGTTG | p.Thr344ValfsTer18 | p.T344Vfs*18 | P22830 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
FECH | insertion | In_Frame_Ins | novel | c.724_725insCTGGTCTCGACCTCCTGGGCCCAG | p.Cys242delinsSerGlyLeuAspLeuLeuGlyProGly | p.C242delinsSGLDLLGPG | P22830 | protein_coding | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FECH | insertion | In_Frame_Ins | novel | c.954_955insGTTTGCTGTTATGTTGTGATCAATCTGATTATTGAAATAACAAATACC | p.Gly318_Pro319insValCysCysTyrValValIleAsnLeuIleIleGluIleThrAsnThr | p.G318_P319insVCCYVVINLIIEITNT | P22830 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
FECH | SNV | Missense_Mutation | c.800C>T | p.Ser267Phe | p.S267F | P22830 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
FECH | SNV | Missense_Mutation | c.181N>G | p.Gln61Glu | p.Q61E | P22830 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
FECH | SNV | Missense_Mutation | rs770820411 | c.862N>A | p.Ala288Thr | p.A288T | P22830 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FECH | SNV | Missense_Mutation | rs746310270 | c.661N>T | p.Arg221Trp | p.R221W | P22830 | protein_coding | deleterious(0.02) | possibly_damaging(0.714) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
FECH | SNV | Missense_Mutation | novel | c.417G>T | p.Lys139Asn | p.K139N | P22830 | protein_coding | tolerated(0.19) | possibly_damaging(0.722) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FECH | SNV | Missense_Mutation | rs141888884 | c.911N>A | p.Arg304Gln | p.R304Q | P22830 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-A5-A0G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
FECH | SNV | Missense_Mutation | rs141888884 | c.911N>A | p.Arg304Gln | p.R304Q | P22830 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2235 | FECH | ENZYME | Methyl aminolevulinate | |||
2235 | FECH | ENZYME | Cholic Acid |
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