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Gene: ERI3 |
Gene summary for ERI3 |
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Gene information | Species | Human | Gene symbol | ERI3 | Gene ID | 79033 |
Gene name | ERI1 exoribonuclease family member 3 | |
Gene Alias | PINT1 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000459 | UniProtAcc | B4DN03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79033 | ERI3 | LZE7T | Human | Esophagus | ESCC | 5.66e-07 | 6.18e-01 | 0.0667 |
79033 | ERI3 | LZE8T | Human | Esophagus | ESCC | 8.15e-05 | 2.23e-01 | 0.067 |
79033 | ERI3 | LZE20T | Human | Esophagus | ESCC | 4.16e-08 | 2.18e-01 | 0.0662 |
79033 | ERI3 | LZE22T | Human | Esophagus | ESCC | 2.67e-03 | 5.58e-01 | 0.068 |
79033 | ERI3 | LZE24T | Human | Esophagus | ESCC | 4.24e-28 | 8.17e-01 | 0.0596 |
79033 | ERI3 | LZE21T | Human | Esophagus | ESCC | 4.02e-02 | 4.73e-01 | 0.0655 |
79033 | ERI3 | LZE6T | Human | Esophagus | ESCC | 8.35e-05 | 3.44e-01 | 0.0845 |
79033 | ERI3 | P1T-E | Human | Esophagus | ESCC | 9.37e-04 | 4.47e-01 | 0.0875 |
79033 | ERI3 | P2T-E | Human | Esophagus | ESCC | 1.24e-58 | 1.21e+00 | 0.1177 |
79033 | ERI3 | P4T-E | Human | Esophagus | ESCC | 4.56e-23 | 6.92e-01 | 0.1323 |
79033 | ERI3 | P5T-E | Human | Esophagus | ESCC | 9.75e-26 | 6.29e-01 | 0.1327 |
79033 | ERI3 | P8T-E | Human | Esophagus | ESCC | 7.85e-28 | 6.40e-01 | 0.0889 |
79033 | ERI3 | P9T-E | Human | Esophagus | ESCC | 1.34e-21 | 5.38e-01 | 0.1131 |
79033 | ERI3 | P10T-E | Human | Esophagus | ESCC | 2.13e-58 | 1.10e+00 | 0.116 |
79033 | ERI3 | P11T-E | Human | Esophagus | ESCC | 1.77e-24 | 8.54e-01 | 0.1426 |
79033 | ERI3 | P12T-E | Human | Esophagus | ESCC | 8.70e-34 | 6.48e-01 | 0.1122 |
79033 | ERI3 | P15T-E | Human | Esophagus | ESCC | 2.82e-23 | 6.70e-01 | 0.1149 |
79033 | ERI3 | P16T-E | Human | Esophagus | ESCC | 2.04e-44 | 7.59e-01 | 0.1153 |
79033 | ERI3 | P17T-E | Human | Esophagus | ESCC | 4.82e-16 | 8.30e-01 | 0.1278 |
79033 | ERI3 | P19T-E | Human | Esophagus | ESCC | 5.39e-16 | 1.82e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00004602 | Oral cavity | OSCC | maturation of 5.8S rRNA | 28/7305 | 35/18723 | 8.71e-07 | 1.19e-05 | 28 |
GO:00004692 | Oral cavity | OSCC | cleavage involved in rRNA processing | 23/7305 | 27/18723 | 1.06e-06 | 1.42e-05 | 23 |
GO:00004662 | Oral cavity | OSCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 19/7305 | 24/18723 | 7.18e-05 | 5.67e-04 | 19 |
GO:00905032 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis, exonucleolytic | 29/7305 | 42/18723 | 7.73e-05 | 6.00e-04 | 29 |
GO:0031125 | Oral cavity | OSCC | rRNA 3'-end processing | 8/7305 | 10/18723 | 1.03e-02 | 3.53e-02 | 8 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
GO:000636418 | Oral cavity | LP | rRNA processing | 134/4623 | 225/18723 | 6.08e-29 | 4.23e-26 | 134 |
GO:001607218 | Oral cavity | LP | rRNA metabolic process | 136/4623 | 236/18723 | 2.37e-27 | 1.48e-24 | 136 |
GO:003447014 | Oral cavity | LP | ncRNA processing | 184/4623 | 395/18723 | 1.20e-21 | 3.12e-19 | 184 |
GO:003466011 | Oral cavity | LP | ncRNA metabolic process | 205/4623 | 485/18723 | 6.46e-18 | 1.09e-15 | 205 |
GO:000046011 | Oral cavity | LP | maturation of 5.8S rRNA | 23/4623 | 35/18723 | 3.43e-07 | 1.00e-05 | 23 |
GO:009050111 | Oral cavity | LP | RNA phosphodiester bond hydrolysis | 63/4623 | 152/18723 | 3.88e-06 | 8.13e-05 | 63 |
GO:00004691 | Oral cavity | LP | cleavage involved in rRNA processing | 18/4623 | 27/18723 | 4.92e-06 | 9.94e-05 | 18 |
GO:003112311 | Oral cavity | LP | RNA 3'-end processing | 48/4623 | 116/18723 | 5.51e-05 | 7.58e-04 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ERI3 | SNV | Missense_Mutation | rs776082167 | c.563N>C | p.Val188Ala | p.V188A | O43414 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
ERI3 | SNV | Missense_Mutation | c.775C>A | p.Gln259Lys | p.Q259K | O43414 | protein_coding | tolerated(0.45) | benign(0.005) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
ERI3 | SNV | Missense_Mutation | novel | c.266G>A | p.Arg89Gln | p.R89Q | O43414 | protein_coding | tolerated_low_confidence(0.13) | benign(0.116) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ERI3 | SNV | Missense_Mutation | rs201922019 | c.167N>T | p.Ser56Leu | p.S56L | O43414 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
ERI3 | SNV | Missense_Mutation | rs779614935 | c.890G>A | p.Gly297Asp | p.G297D | O43414 | protein_coding | tolerated(0.58) | benign(0.094) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ERI3 | SNV | Missense_Mutation | c.350N>T | p.Ser117Phe | p.S117F | O43414 | protein_coding | deleterious(0) | possibly_damaging(0.601) | TCGA-AA-3675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ERI3 | SNV | Missense_Mutation | c.373G>A | p.Ala125Thr | p.A125T | O43414 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ERI3 | SNV | Missense_Mutation | c.427N>C | p.Tyr143His | p.Y143H | O43414 | protein_coding | deleterious(0) | benign(0.309) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ERI3 | SNV | Missense_Mutation | c.950N>T | p.Ala317Val | p.A317V | O43414 | protein_coding | tolerated(0.09) | possibly_damaging(0.851) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ERI3 | SNV | Missense_Mutation | novel | c.388G>A | p.Ala130Thr | p.A130T | O43414 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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