![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EMC4 |
Gene summary for EMC4 |
![]() |
Gene information | Species | Human | Gene symbol | EMC4 | Gene ID | 51234 |
Gene name | ER membrane protein complex subunit 4 | |
Gene Alias | PIG17 | |
Cytomap | 15q14 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A0S2Z598 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51234 | EMC4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.13e-03 | 2.08e-01 | -0.1808 |
51234 | EMC4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.25e-03 | 2.41e-01 | -0.0811 |
51234 | EMC4 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.31e-06 | 2.45e-01 | -0.1954 |
51234 | EMC4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.73e-15 | 3.85e-01 | 0.294 |
51234 | EMC4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.88e-15 | 5.82e-01 | 0.281 |
51234 | EMC4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.66e-03 | 1.41e-01 | 0.3859 |
51234 | EMC4 | AEH-subject1 | Human | Endometrium | AEH | 3.48e-18 | -3.80e-01 | -0.3059 |
51234 | EMC4 | AEH-subject2 | Human | Endometrium | AEH | 3.91e-12 | -3.65e-01 | -0.2525 |
51234 | EMC4 | AEH-subject3 | Human | Endometrium | AEH | 3.87e-10 | -2.90e-01 | -0.2576 |
51234 | EMC4 | AEH-subject4 | Human | Endometrium | AEH | 1.11e-12 | -4.47e-01 | -0.2657 |
51234 | EMC4 | AEH-subject5 | Human | Endometrium | AEH | 3.13e-09 | -3.26e-01 | -0.2953 |
51234 | EMC4 | EEC-subject1 | Human | Endometrium | EEC | 3.75e-16 | -3.85e-01 | -0.2682 |
51234 | EMC4 | EEC-subject2 | Human | Endometrium | EEC | 2.08e-28 | -4.78e-01 | -0.2607 |
51234 | EMC4 | EEC-subject3 | Human | Endometrium | EEC | 4.95e-39 | -4.37e-01 | -0.2525 |
51234 | EMC4 | EEC-subject4 | Human | Endometrium | EEC | 2.19e-07 | -2.70e-01 | -0.2571 |
51234 | EMC4 | EEC-subject5 | Human | Endometrium | EEC | 6.47e-07 | -2.73e-01 | -0.249 |
51234 | EMC4 | GSM5276934 | Human | Endometrium | EEC | 8.14e-03 | 8.28e-03 | -0.0913 |
51234 | EMC4 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.56e-26 | -1.65e-01 | -0.1869 |
51234 | EMC4 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.10e-27 | -2.22e-01 | -0.1875 |
51234 | EMC4 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.06e-32 | -1.53e-01 | -0.1883 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005120514 | Oral cavity | LP | protein insertion into membrane | 35/4623 | 57/18723 | 4.38e-09 | 1.86e-07 | 35 |
GO:000702913 | Oral cavity | LP | endoplasmic reticulum organization | 41/4623 | 87/18723 | 4.49e-06 | 9.16e-05 | 41 |
GO:004504811 | Oral cavity | LP | protein insertion into ER membrane | 15/4623 | 22/18723 | 2.08e-05 | 3.44e-04 | 15 |
GO:00718161 | Oral cavity | LP | tail-anchored membrane protein insertion into ER membrane | 12/4623 | 17/18723 | 8.70e-05 | 1.10e-03 | 12 |
GO:00450501 | Oral cavity | LP | protein insertion into ER membrane by stop-transfer membrane-anchor sequence | 8/4623 | 10/18723 | 3.78e-04 | 3.67e-03 | 8 |
GO:009015016 | Prostate | BPH | establishment of protein localization to membrane | 77/3107 | 260/18723 | 1.06e-07 | 2.56e-06 | 77 |
GO:00070293 | Prostate | BPH | endoplasmic reticulum organization | 26/3107 | 87/18723 | 1.45e-03 | 8.61e-03 | 26 |
GO:00512055 | Prostate | BPH | protein insertion into membrane | 19/3107 | 57/18723 | 1.51e-03 | 8.88e-03 | 19 |
GO:009015017 | Prostate | Tumor | establishment of protein localization to membrane | 77/3246 | 260/18723 | 6.46e-07 | 1.33e-05 | 77 |
GO:000702912 | Prostate | Tumor | endoplasmic reticulum organization | 27/3246 | 87/18723 | 1.24e-03 | 7.83e-03 | 27 |
GO:005120513 | Prostate | Tumor | protein insertion into membrane | 19/3246 | 57/18723 | 2.54e-03 | 1.41e-02 | 19 |
GO:009015024 | Skin | cSCC | establishment of protein localization to membrane | 123/4864 | 260/18723 | 8.34e-14 | 5.18e-12 | 123 |
GO:00512058 | Skin | cSCC | protein insertion into membrane | 34/4864 | 57/18723 | 8.07e-08 | 1.96e-06 | 34 |
GO:00450484 | Skin | cSCC | protein insertion into ER membrane | 16/4864 | 22/18723 | 5.92e-06 | 8.44e-05 | 16 |
GO:00070296 | Skin | cSCC | endoplasmic reticulum organization | 42/4864 | 87/18723 | 6.36e-06 | 8.92e-05 | 42 |
GO:00718164 | Skin | cSCC | tail-anchored membrane protein insertion into ER membrane | 13/4864 | 17/18723 | 1.92e-05 | 2.27e-04 | 13 |
GO:00450504 | Skin | cSCC | protein insertion into ER membrane by stop-transfer membrane-anchor sequence | 9/4864 | 10/18723 | 4.11e-05 | 4.34e-04 | 9 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:000702915 | Thyroid | PTC | endoplasmic reticulum organization | 51/5968 | 87/18723 | 2.37e-07 | 4.15e-06 | 51 |
GO:00512059 | Thyroid | PTC | protein insertion into membrane | 35/5968 | 57/18723 | 4.20e-06 | 5.20e-05 | 35 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC4 | SNV | Missense_Mutation | novel | c.175N>C | p.Glu59Gln | p.E59Q | Q5J8M3 | protein_coding | tolerated(0.18) | probably_damaging(0.912) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
EMC4 | SNV | Missense_Mutation | c.157C>T | p.Pro53Ser | p.P53S | Q5J8M3 | protein_coding | tolerated(0.98) | benign(0.023) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EMC4 | SNV | Missense_Mutation | c.518N>T | p.Arg173Ile | p.R173I | Q5J8M3 | protein_coding | deleterious(0.03) | possibly_damaging(0.56) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EMC4 | SNV | Missense_Mutation | c.79G>T | p.Gly27Cys | p.G27C | Q5J8M3 | protein_coding | deleterious(0.03) | possibly_damaging(0.829) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
EMC4 | SNV | Missense_Mutation | rs761614836 | c.203N>A | p.Arg68His | p.R68H | Q5J8M3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EMC4 | SNV | Missense_Mutation | novel | c.237N>T | p.Gln79His | p.Q79H | Q5J8M3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC4 | SNV | Missense_Mutation | novel | c.337N>A | p.Leu113Ile | p.L113I | Q5J8M3 | protein_coding | tolerated(0.14) | benign(0.097) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EMC4 | insertion | Frame_Shift_Ins | novel | c.176_177insCTTAGTGCTTCCTAAAGCCACTTCC | p.Glu59AspfsTer119 | p.E59Dfs*119 | Q5J8M3 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EMC4 | SNV | Missense_Mutation | c.518N>C | p.Arg173Thr | p.R173T | Q5J8M3 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EMC4 | SNV | Missense_Mutation | c.323N>C | p.Arg108Pro | p.R108P | Q5J8M3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-77-6845-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |