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Gene: ELOVL1 |
Gene summary for ELOVL1 |
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Gene information | Species | Human | Gene symbol | ELOVL1 | Gene ID | 64834 |
Gene name | ELOVL fatty acid elongase 1 | |
Gene Alias | CGI-88 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | Q9BW60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64834 | ELOVL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.38e-02 | 1.09e-01 | 0.0155 |
64834 | ELOVL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.73e-12 | 4.57e-01 | -0.1808 |
64834 | ELOVL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.12e-12 | 4.83e-01 | -0.0811 |
64834 | ELOVL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.29e-08 | 2.98e-01 | -0.1088 |
64834 | ELOVL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.66e-18 | 3.88e-01 | -0.1954 |
64834 | ELOVL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.49e-02 | 5.35e-01 | -0.2602 |
64834 | ELOVL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.69e-06 | 6.24e-01 | -0.2196 |
64834 | ELOVL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.60e-07 | 3.25e-01 | -0.1207 |
64834 | ELOVL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.78e-17 | 5.40e-01 | -0.1526 |
64834 | ELOVL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.30e-12 | 3.61e-01 | -0.1464 |
64834 | ELOVL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.41e-06 | 2.25e-01 | -0.1001 |
64834 | ELOVL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.59e-16 | 5.24e-01 | -0.059 |
64834 | ELOVL1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.38e-03 | 2.87e-01 | -0.2061 |
64834 | ELOVL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.89e-10 | 3.11e-01 | 0.096 |
64834 | ELOVL1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.02e-07 | 3.31e-01 | 0.0528 |
64834 | ELOVL1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.41e-05 | 4.42e-01 | 0.0131 |
64834 | ELOVL1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.06e-03 | 3.01e-01 | -0.0177 |
64834 | ELOVL1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.09e-02 | 3.53e-01 | 0.0171 |
64834 | ELOVL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.13e-04 | 2.77e-01 | 0.0338 |
64834 | ELOVL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.34e-09 | 2.97e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00092592 | Colorectum | MSS | ribonucleotide metabolic process | 123/3467 | 385/18723 | 1.17e-10 | 1.20e-08 | 123 |
GO:00196932 | Colorectum | MSS | ribose phosphate metabolic process | 124/3467 | 396/18723 | 4.11e-10 | 3.49e-08 | 124 |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
GO:00091522 | Colorectum | MSS | purine ribonucleotide biosynthetic process | 57/3467 | 169/18723 | 1.63e-06 | 5.32e-05 | 57 |
GO:00092602 | Colorectum | MSS | ribonucleotide biosynthetic process | 59/3467 | 182/18723 | 4.55e-06 | 1.27e-04 | 59 |
GO:00463902 | Colorectum | MSS | ribose phosphate biosynthetic process | 60/3467 | 190/18723 | 9.54e-06 | 2.33e-04 | 60 |
GO:00061642 | Colorectum | MSS | purine nucleotide biosynthetic process | 59/3467 | 191/18723 | 2.36e-05 | 4.97e-04 | 59 |
GO:00725222 | Colorectum | MSS | purine-containing compound biosynthetic process | 61/3467 | 200/18723 | 2.65e-05 | 5.46e-04 | 61 |
GO:00508782 | Colorectum | MSS | regulation of body fluid levels | 99/3467 | 379/18723 | 1.40e-04 | 2.07e-03 | 99 |
GO:19012932 | Colorectum | MSS | nucleoside phosphate biosynthetic process | 71/3467 | 256/18723 | 1.80e-04 | 2.56e-03 | 71 |
GO:00091652 | Colorectum | MSS | nucleotide biosynthetic process | 70/3467 | 254/18723 | 2.44e-04 | 3.34e-03 | 70 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
GO:0046394 | Colorectum | MSS | carboxylic acid biosynthetic process | 76/3467 | 314/18723 | 6.71e-03 | 4.38e-02 | 76 |
GO:0016053 | Colorectum | MSS | organic acid biosynthetic process | 76/3467 | 316/18723 | 7.88e-03 | 4.84e-02 | 76 |
GO:00091173 | Colorectum | MSI-H | nucleotide metabolic process | 53/1319 | 489/18723 | 1.16e-03 | 1.92e-02 | 53 |
GO:00067533 | Colorectum | MSI-H | nucleoside phosphate metabolic process | 53/1319 | 497/18723 | 1.66e-03 | 2.45e-02 | 53 |
GO:00061633 | Colorectum | MSI-H | purine nucleotide metabolic process | 44/1319 | 396/18723 | 1.81e-03 | 2.61e-02 | 44 |
GO:00463941 | Colorectum | MSI-H | carboxylic acid biosynthetic process | 36/1319 | 314/18723 | 2.68e-03 | 3.48e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00062 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
hsa000621 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa01040 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa010401 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa000622 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010402 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa0006211 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010403 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELOVL1 | SNV | Missense_Mutation | c.672N>A | p.Ser224Arg | p.S224R | Q9BW60 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-JW-A5VG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ELOVL1 | SNV | Missense_Mutation | c.788G>A | p.Arg263His | p.R263H | Q9BW60 | protein_coding | deleterious(0.03) | benign(0.223) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ELOVL1 | SNV | Missense_Mutation | rs754465886 | c.143N>A | p.Arg48His | p.R48H | Q9BW60 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ELOVL1 | SNV | Missense_Mutation | c.601N>G | p.Met201Val | p.M201V | Q9BW60 | protein_coding | deleterious(0) | benign(0.088) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ELOVL1 | SNV | Missense_Mutation | rs201783931 | c.325N>T | p.Arg109Trp | p.R109W | Q9BW60 | protein_coding | tolerated(0.08) | benign(0.052) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ELOVL1 | SNV | Missense_Mutation | c.684G>C | p.Gln228His | p.Q228H | Q9BW60 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-RU-A8FL-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ELOVL1 | SNV | Missense_Mutation | c.602T>C | p.Met201Thr | p.M201T | Q9BW60 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ELOVL1 | SNV | Missense_Mutation | rs201270403 | c.157C>T | p.Arg53Trp | p.R53W | Q9BW60 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ELOVL1 | SNV | Missense_Mutation | rs754465886 | c.143G>A | p.Arg48His | p.R48H | Q9BW60 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ELOVL1 | SNV | Missense_Mutation | c.52N>T | p.Arg18Trp | p.R18W | Q9BW60 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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