Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064174 | Colorectum | FAP | regulation of translation | 111/2622 | 468/18723 | 8.47e-09 | 1.13e-06 | 111 |
GO:00718264 | Colorectum | FAP | ribonucleoprotein complex subunit organization | 59/2622 | 227/18723 | 1.18e-06 | 5.26e-05 | 59 |
GO:00226184 | Colorectum | FAP | ribonucleoprotein complex assembly | 57/2622 | 220/18723 | 1.99e-06 | 8.03e-05 | 57 |
GO:00021834 | Colorectum | FAP | cytoplasmic translational initiation | 16/2622 | 34/18723 | 3.74e-06 | 1.29e-04 | 16 |
GO:00064463 | Colorectum | FAP | regulation of translational initiation | 26/2622 | 79/18723 | 1.54e-05 | 4.01e-04 | 26 |
GO:00190804 | Colorectum | FAP | viral gene expression | 29/2622 | 94/18723 | 2.07e-05 | 5.05e-04 | 29 |
GO:00064134 | Colorectum | FAP | translational initiation | 34/2622 | 118/18723 | 2.13e-05 | 5.12e-04 | 34 |
GO:00017324 | Colorectum | FAP | formation of cytoplasmic translation initiation complex | 9/2622 | 16/18723 | 9.19e-05 | 1.59e-03 | 9 |
GO:00755224 | Colorectum | FAP | IRES-dependent viral translational initiation | 7/2622 | 11/18723 | 2.06e-04 | 2.95e-03 | 7 |
GO:00226134 | Colorectum | FAP | ribonucleoprotein complex biogenesis | 91/2622 | 463/18723 | 4.28e-04 | 5.12e-03 | 91 |
GO:00190814 | Colorectum | FAP | viral translation | 8/2622 | 16/18723 | 6.58e-04 | 7.19e-03 | 8 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:00160325 | Colorectum | CRC | viral process | 95/2078 | 415/18723 | 3.31e-12 | 3.30e-09 | 95 |
GO:00226185 | Colorectum | CRC | ribonucleoprotein complex assembly | 48/2078 | 220/18723 | 3.16e-06 | 1.44e-04 | 48 |
GO:00718265 | Colorectum | CRC | ribonucleoprotein complex subunit organization | 49/2078 | 227/18723 | 3.44e-06 | 1.51e-04 | 49 |
GO:00190805 | Colorectum | CRC | viral gene expression | 26/2078 | 94/18723 | 7.43e-06 | 2.72e-04 | 26 |
GO:00064175 | Colorectum | CRC | regulation of translation | 82/2078 | 468/18723 | 1.79e-05 | 5.40e-04 | 82 |
GO:00226135 | Colorectum | CRC | ribonucleoprotein complex biogenesis | 76/2078 | 463/18723 | 3.04e-04 | 4.78e-03 | 76 |
GO:00755225 | Colorectum | CRC | IRES-dependent viral translational initiation | 5/2078 | 11/18723 | 4.35e-03 | 3.47e-02 | 5 |
GO:00190815 | Colorectum | CRC | viral translation | 6/2078 | 16/18723 | 5.55e-03 | 4.19e-02 | 6 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF3B | SNV | Missense_Mutation | | c.1311C>A | p.Phe437Leu | p.F437L | P55884 | protein_coding | tolerated(0.06) | benign(0.184) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF3B | SNV | Missense_Mutation | novel | c.2194N>C | p.Glu732Gln | p.E732Q | P55884 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF3B | SNV | Missense_Mutation | | c.2264A>G | p.Glu755Gly | p.E755G | P55884 | protein_coding | deleterious(0) | benign(0.218) | TCGA-E2-A15D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF3B | insertion | Nonsense_Mutation | novel | c.781_782insCTAGAATTATCAAATACAGGTAATGCTGC | p.Phe261SerfsTer8 | p.F261Sfs*8 | P55884 | protein_coding | | | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
EIF3B | insertion | Frame_Shift_Ins | novel | c.1598_1599insGCTAATAAGCTTTTTACTGAGA | p.Pro534LeufsTer19 | p.P534Lfs*19 | P55884 | protein_coding | | | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
EIF3B | insertion | Frame_Shift_Ins | novel | c.1995_1996insTCCAGGACTCAGGCCAAGCCCGCACAGA | p.Val666SerfsTer20 | p.V666Sfs*20 | P55884 | protein_coding | | | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF3B | insertion | Frame_Shift_Ins | novel | c.1802_1803insCCGCCCTTCCAGGCAGGGAG | p.Glu601AspfsTer35 | p.E601Dfs*35 | P55884 | protein_coding | | | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
EIF3B | SNV | Missense_Mutation | rs759606657 | c.1907C>T | p.Ala636Val | p.A636V | P55884 | protein_coding | tolerated(0.4) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF3B | SNV | Missense_Mutation | rs370274071 | c.1996G>A | p.Val666Ile | p.V666I | P55884 | protein_coding | tolerated(0.07) | benign(0.342) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF3B | SNV | Missense_Mutation | | c.1311C>G | p.Phe437Leu | p.F437L | P55884 | protein_coding | tolerated(0.06) | benign(0.184) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |