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Gene: EFR3A |
Gene summary for EFR3A |
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Gene information | Species | Human | Gene symbol | EFR3A | Gene ID | 23167 |
Gene name | EFR3 homolog A | |
Gene Alias | EFR3A | |
Cytomap | 8q24.22 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q14156 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23167 | EFR3A | LZE4T | Human | Esophagus | ESCC | 3.98e-20 | 5.96e-01 | 0.0811 |
23167 | EFR3A | LZE8T | Human | Esophagus | ESCC | 1.11e-02 | 6.35e-02 | 0.067 |
23167 | EFR3A | LZE20T | Human | Esophagus | ESCC | 5.11e-04 | 2.88e-01 | 0.0662 |
23167 | EFR3A | LZE22T | Human | Esophagus | ESCC | 1.78e-02 | 2.43e-01 | 0.068 |
23167 | EFR3A | LZE24T | Human | Esophagus | ESCC | 8.95e-13 | 2.62e-01 | 0.0596 |
23167 | EFR3A | LZE21T | Human | Esophagus | ESCC | 9.52e-03 | 2.07e-01 | 0.0655 |
23167 | EFR3A | P1T-E | Human | Esophagus | ESCC | 4.55e-06 | 3.06e-01 | 0.0875 |
23167 | EFR3A | P2T-E | Human | Esophagus | ESCC | 2.75e-24 | 5.03e-01 | 0.1177 |
23167 | EFR3A | P4T-E | Human | Esophagus | ESCC | 1.72e-19 | 5.13e-01 | 0.1323 |
23167 | EFR3A | P5T-E | Human | Esophagus | ESCC | 2.25e-22 | 4.55e-01 | 0.1327 |
23167 | EFR3A | P8T-E | Human | Esophagus | ESCC | 1.88e-21 | 4.73e-01 | 0.0889 |
23167 | EFR3A | P9T-E | Human | Esophagus | ESCC | 9.53e-17 | 3.92e-01 | 0.1131 |
23167 | EFR3A | P10T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.39e-01 | 0.116 |
23167 | EFR3A | P11T-E | Human | Esophagus | ESCC | 6.95e-11 | 6.13e-01 | 0.1426 |
23167 | EFR3A | P12T-E | Human | Esophagus | ESCC | 2.16e-56 | 1.04e+00 | 0.1122 |
23167 | EFR3A | P15T-E | Human | Esophagus | ESCC | 4.76e-33 | 8.08e-01 | 0.1149 |
23167 | EFR3A | P16T-E | Human | Esophagus | ESCC | 9.26e-31 | 6.03e-01 | 0.1153 |
23167 | EFR3A | P17T-E | Human | Esophagus | ESCC | 2.94e-09 | 5.76e-01 | 0.1278 |
23167 | EFR3A | P19T-E | Human | Esophagus | ESCC | 2.82e-08 | 6.75e-01 | 0.1662 |
23167 | EFR3A | P20T-E | Human | Esophagus | ESCC | 1.69e-18 | 4.97e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265926 | Skin | cSCC | protein localization to plasma membrane | 118/4864 | 284/18723 | 6.43e-09 | 2.11e-07 | 118 |
GO:199077824 | Skin | cSCC | protein localization to cell periphery | 134/4864 | 333/18723 | 7.09e-09 | 2.30e-07 | 134 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:007265928 | Thyroid | ATC | protein localization to plasma membrane | 161/6293 | 284/18723 | 8.45e-16 | 6.52e-14 | 161 |
GO:199077826 | Thyroid | ATC | protein localization to cell periphery | 181/6293 | 333/18723 | 3.72e-15 | 2.56e-13 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFR3A | SNV | Missense_Mutation | c.986C>A | p.Ser329Tyr | p.S329Y | Q14156 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
EFR3A | SNV | Missense_Mutation | c.482N>A | p.Arg161Gln | p.R161Q | Q14156 | protein_coding | tolerated(0.1) | benign(0.033) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
EFR3A | SNV | Missense_Mutation | c.209N>A | p.Arg70His | p.R70H | Q14156 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EFR3A | SNV | Missense_Mutation | novel | c.266N>C | p.His89Pro | p.H89P | Q14156 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
EFR3A | SNV | Missense_Mutation | c.2434N>C | p.Glu812Gln | p.E812Q | Q14156 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
EFR3A | insertion | Frame_Shift_Ins | novel | c.1907_1908insCAAATGCACTATTTTGGAA | p.Pro637LysfsTer14 | p.P637Kfs*14 | Q14156 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
EFR3A | insertion | Nonsense_Mutation | novel | c.2446_2447insATTAGTAAAAAATTATTTCATGTATA | p.Pro816HisfsTer2 | p.P816Hfs*2 | Q14156 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EFR3A | SNV | Missense_Mutation | rs148528328 | c.908G>A | p.Arg303His | p.R303H | Q14156 | protein_coding | tolerated(0.3) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EFR3A | SNV | Missense_Mutation | c.679N>C | p.Glu227Gln | p.E227Q | Q14156 | protein_coding | tolerated(0.08) | benign(0.103) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EFR3A | SNV | Missense_Mutation | c.1734N>T | p.Leu578Phe | p.L578F | Q14156 | protein_coding | deleterious(0.01) | benign(0.379) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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