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Gene: EDN1 |
Gene summary for EDN1 |
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Gene information | Species | Human | Gene symbol | EDN1 | Gene ID | 1906 |
Gene name | endothelin 1 | |
Gene Alias | ARCND3 | |
Cytomap | 6p24.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P05305 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1906 | EDN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.20e-08 | 6.73e-01 | -0.0811 |
1906 | EDN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.64e-08 | 3.18e-01 | -0.1954 |
1906 | EDN1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.11e-04 | 3.55e-01 | 0.0588 |
1906 | EDN1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.92e-16 | 7.07e-01 | 0.281 |
1906 | EDN1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.37e-02 | 1.20e-01 | 0.3859 |
1906 | EDN1 | A002-C-203 | Human | Colorectum | FAP | 3.23e-04 | 2.57e-01 | 0.2786 |
1906 | EDN1 | A001-C-108 | Human | Colorectum | FAP | 1.25e-09 | 4.49e-01 | -0.0272 |
1906 | EDN1 | A001-C-104 | Human | Colorectum | FAP | 2.57e-10 | 4.46e-01 | 0.0184 |
1906 | EDN1 | A001-C-014 | Human | Colorectum | FAP | 1.01e-02 | 1.82e-01 | 0.0135 |
1906 | EDN1 | A001-C-203 | Human | Colorectum | FAP | 8.84e-07 | 3.38e-01 | -0.0481 |
1906 | EDN1 | A008-E-015 | Human | Colorectum | FAP | 5.76e-04 | 1.90e-01 | 0.0177 |
1906 | EDN1 | LZE4T | Human | Esophagus | ESCC | 2.68e-17 | 1.08e+00 | 0.0811 |
1906 | EDN1 | LZE7T | Human | Esophagus | ESCC | 3.83e-09 | 1.57e+00 | 0.0667 |
1906 | EDN1 | LZE22T | Human | Esophagus | ESCC | 2.92e-02 | 1.55e+00 | 0.068 |
1906 | EDN1 | LZE24T | Human | Esophagus | ESCC | 2.82e-15 | 1.54e+00 | 0.0596 |
1906 | EDN1 | P4T-E | Human | Esophagus | ESCC | 1.02e-06 | 7.29e-01 | 0.1323 |
1906 | EDN1 | P5T-E | Human | Esophagus | ESCC | 9.20e-18 | 1.02e+00 | 0.1327 |
1906 | EDN1 | P8T-E | Human | Esophagus | ESCC | 2.00e-19 | 1.13e+00 | 0.0889 |
1906 | EDN1 | P9T-E | Human | Esophagus | ESCC | 2.01e-24 | 1.31e+00 | 0.1131 |
1906 | EDN1 | P10T-E | Human | Esophagus | ESCC | 5.95e-14 | 4.31e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0071241 | Colorectum | AD | cellular response to inorganic substance | 68/3918 | 226/18723 | 6.98e-04 | 7.10e-03 | 68 |
GO:0110020 | Colorectum | AD | regulation of actomyosin structure organization | 35/3918 | 100/18723 | 7.78e-04 | 7.78e-03 | 35 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0007589 | Colorectum | AD | body fluid secretion | 33/3918 | 93/18723 | 8.26e-04 | 8.13e-03 | 33 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0071453 | Colorectum | AD | cellular response to oxygen levels | 55/3918 | 177/18723 | 9.48e-04 | 8.96e-03 | 55 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:0015732 | Colorectum | AD | prostaglandin transport | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0045429 | Colorectum | AD | positive regulation of nitric oxide biosynthetic process | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:1904407 | Colorectum | AD | positive regulation of nitric oxide metabolic process | 17/3918 | 41/18723 | 2.29e-03 | 1.79e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054184 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa04926 | Colorectum | MSS | Relaxin signaling pathway | 40/1875 | 129/8465 | 1.18e-02 | 3.99e-02 | 2.44e-02 | 40 |
hsa054185 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa049261 | Colorectum | MSS | Relaxin signaling pathway | 40/1875 | 129/8465 | 1.18e-02 | 3.99e-02 | 2.44e-02 | 40 |
hsa040666 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa04933 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa04270 | Colorectum | FAP | Vascular smooth muscle contraction | 33/1404 | 134/8465 | 1.05e-02 | 3.74e-02 | 2.28e-02 | 33 |
hsa040667 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
hsa054189 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa049331 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa042701 | Colorectum | FAP | Vascular smooth muscle contraction | 33/1404 | 134/8465 | 1.05e-02 | 3.74e-02 | 2.28e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | ADJ |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | ADJ |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | DCIS |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | DCIS |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | Healthy |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | Healthy |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | Precancer |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | Precancer |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Cervix | ADJ |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Cervix | CC |
EDN1 | EDNRA | EDN1_EDNRA | EDN | CRC | MSI-H |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | ADJ |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | ADJ |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | AEH |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | AEH |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | EEC |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | EEC |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | Healthy |
EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | Healthy |
EDN1 | EDNRA | EDN1_EDNRA | EDN | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
EDN1 | BAS | Lung | Healthy | KRT17,CXCL1,IER3, etc. | 1.53e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EDN1 | SNV | Missense_Mutation | c.346N>T | p.Asp116Tyr | p.D116Y | P05305 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EDN1 | SNV | Missense_Mutation | rs777308039 | c.446C>A | p.Ser149Tyr | p.S149Y | P05305 | protein_coding | tolerated(0.07) | benign(0.121) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EDN1 | SNV | Missense_Mutation | c.557T>A | p.Val186Asp | p.V186D | P05305 | protein_coding | deleterious(0) | possibly_damaging(0.559) | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
EDN1 | insertion | Frame_Shift_Ins | novel | c.155_156insTAACTTATCGTTTTATTATTATTATTCCATTATGTGTTTC | p.Cys53AsnfsTer22 | p.C53Nfs*22 | P05305 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
EDN1 | deletion | Frame_Shift_Del | c.457delN | p.Lys154SerfsTer7 | p.K154Sfs*7 | P05305 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
EDN1 | SNV | Missense_Mutation | c.285N>T | p.Glu95Asp | p.E95D | P05305 | protein_coding | tolerated(0.09) | benign(0.104) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EDN1 | SNV | Missense_Mutation | novel | c.221N>G | p.Val74Gly | p.V74G | P05305 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EDN1 | deletion | Frame_Shift_Del | c.457delN | p.Lys154SerfsTer7 | p.K154Sfs*7 | P05305 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
EDN1 | SNV | Missense_Mutation | rs368802545 | c.143N>A | p.Arg48His | p.R48H | P05305 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
EDN1 | SNV | Missense_Mutation | c.285N>T | p.Glu95Asp | p.E95D | P05305 | protein_coding | tolerated(0.09) | benign(0.104) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | muraglitazar | MURAGLITAZAR | 18794727 | |
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | ANTICONVULSANT | 7509966 | ||
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | OXYGEN THERAPY | 9736447 | ||
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | ANTIPLATELET AGENT | 15253106 | ||
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | TAMOXIFEN | TAMOXIFEN | 8425178 | |
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | NORETHISTERONE ACETATE | 11915588 | ||
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | CANDESARTAN CILEXETIL | 10029562 | ||
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | INSULIN | INSULIN | 11600523 | |
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | THIOURACIL | THIOURACIL | 10967532 | |
1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | CELECOXIB | CELECOXIB | 15539607 |
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