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Gene: DMAC1 |
Gene summary for DMAC1 |
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Gene information | Species | Human | Gene symbol | DMAC1 | Gene ID | 90871 |
Gene name | distal membrane arm assembly component 1 | |
Gene Alias | C9orf123 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96GE9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90871 | DMAC1 | GSM4909281 | Human | Breast | IDC | 1.18e-07 | 3.67e-01 | 0.21 |
90871 | DMAC1 | GSM4909282 | Human | Breast | IDC | 3.15e-34 | 7.05e-01 | -0.0288 |
90871 | DMAC1 | GSM4909285 | Human | Breast | IDC | 2.13e-18 | 4.94e-01 | 0.21 |
90871 | DMAC1 | GSM4909286 | Human | Breast | IDC | 2.83e-15 | 3.18e-01 | 0.1081 |
90871 | DMAC1 | GSM4909287 | Human | Breast | IDC | 3.82e-07 | 4.00e-01 | 0.2057 |
90871 | DMAC1 | GSM4909289 | Human | Breast | IDC | 4.56e-02 | 4.14e-01 | 0.1064 |
90871 | DMAC1 | GSM4909290 | Human | Breast | IDC | 5.68e-46 | 1.01e+00 | 0.2096 |
90871 | DMAC1 | GSM4909293 | Human | Breast | IDC | 5.99e-26 | 6.15e-01 | 0.1581 |
90871 | DMAC1 | GSM4909298 | Human | Breast | IDC | 1.65e-04 | 2.29e-01 | 0.1551 |
90871 | DMAC1 | GSM4909305 | Human | Breast | IDC | 2.32e-11 | 4.65e-01 | 0.0436 |
90871 | DMAC1 | GSM4909306 | Human | Breast | IDC | 3.57e-09 | 4.24e-01 | 0.1564 |
90871 | DMAC1 | GSM4909307 | Human | Breast | IDC | 5.60e-03 | 3.21e-01 | 0.1569 |
90871 | DMAC1 | GSM4909308 | Human | Breast | IDC | 1.71e-11 | 3.79e-01 | 0.158 |
90871 | DMAC1 | GSM4909311 | Human | Breast | IDC | 3.98e-11 | 1.29e-01 | 0.1534 |
90871 | DMAC1 | GSM4909319 | Human | Breast | IDC | 1.88e-12 | -3.14e-02 | 0.1563 |
90871 | DMAC1 | GSM4909321 | Human | Breast | IDC | 1.03e-02 | 7.71e-02 | 0.1559 |
90871 | DMAC1 | brca1 | Human | Breast | Precancer | 3.69e-10 | -1.89e-01 | -0.0338 |
90871 | DMAC1 | brca2 | Human | Breast | Precancer | 1.78e-08 | -1.89e-01 | -0.024 |
90871 | DMAC1 | brca3 | Human | Breast | Precancer | 1.79e-07 | -1.89e-01 | -0.0263 |
90871 | DMAC1 | DCIS2 | Human | Breast | DCIS | 1.70e-57 | 2.68e-01 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001025732 | Thyroid | ATC | NADH dehydrogenase complex assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
GO:003298132 | Thyroid | ATC | mitochondrial respiratory chain complex I assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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