Tissue | Expression Dynamics | Abbreviation |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DEAF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DEAF1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DEAF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DEAF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000184118 | Thyroid | PTC | neural tube formation | 58/5968 | 102/18723 | 1.59e-07 | 3.03e-06 | 58 |
GO:000183817 | Thyroid | PTC | embryonic epithelial tube formation | 64/5968 | 121/18723 | 1.27e-06 | 1.83e-05 | 64 |
GO:001402016 | Thyroid | PTC | primary neural tube formation | 52/5968 | 94/18723 | 2.14e-06 | 2.89e-05 | 52 |
GO:002191514 | Thyroid | PTC | neural tube development | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
GO:000184310 | Thyroid | PTC | neural tube closure | 49/5968 | 88/18723 | 3.24e-06 | 4.20e-05 | 49 |
GO:00606069 | Thyroid | PTC | tube closure | 49/5968 | 89/18723 | 4.99e-06 | 6.08e-05 | 49 |
GO:003514819 | Thyroid | PTC | tube formation | 73/5968 | 148/18723 | 7.04e-06 | 8.31e-05 | 73 |
GO:006056219 | Thyroid | PTC | epithelial tube morphogenesis | 141/5968 | 325/18723 | 7.52e-06 | 8.73e-05 | 141 |
GO:007217515 | Thyroid | PTC | epithelial tube formation | 66/5968 | 132/18723 | 1.08e-05 | 1.19e-04 | 66 |
GO:00163318 | Thyroid | PTC | morphogenesis of embryonic epithelium | 71/5968 | 147/18723 | 2.31e-05 | 2.29e-04 | 71 |
GO:003359810 | Thyroid | PTC | mammary gland epithelial cell proliferation | 15/5968 | 26/18723 | 5.77e-03 | 2.60e-02 | 15 |
GO:004873233 | Thyroid | ATC | gland development | 210/6293 | 436/18723 | 1.50e-10 | 4.59e-09 | 210 |
GO:006056222 | Thyroid | ATC | epithelial tube morphogenesis | 156/6293 | 325/18723 | 4.48e-08 | 8.14e-07 | 156 |
GO:000184119 | Thyroid | ATC | neural tube formation | 59/6293 | 102/18723 | 4.28e-07 | 6.25e-06 | 59 |
GO:002191515 | Thyroid | ATC | neural tube development | 80/6293 | 152/18723 | 9.87e-07 | 1.29e-05 | 80 |
GO:000183823 | Thyroid | ATC | embryonic epithelial tube formation | 65/6293 | 121/18723 | 4.02e-06 | 4.43e-05 | 65 |
GO:001402017 | Thyroid | ATC | primary neural tube formation | 53/6293 | 94/18723 | 4.69e-06 | 5.11e-05 | 53 |
GO:000184316 | Thyroid | ATC | neural tube closure | 50/6293 | 88/18723 | 6.43e-06 | 6.68e-05 | 50 |
GO:006060616 | Thyroid | ATC | tube closure | 50/6293 | 89/18723 | 9.90e-06 | 9.87e-05 | 50 |
GO:007217522 | Thyroid | ATC | epithelial tube formation | 68/6293 | 132/18723 | 1.59e-05 | 1.48e-04 | 68 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEAF1 | SNV | Missense_Mutation | | c.1085N>T | p.Ser362Leu | p.S362L | O75398 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
DEAF1 | SNV | Missense_Mutation | | c.634N>T | p.Gly212Cys | p.G212C | O75398 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DEAF1 | insertion | Frame_Shift_Ins | novel | c.1413_1414insG | p.Thr472AspfsTer4 | p.T472Dfs*4 | O75398 | protein_coding | | | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DEAF1 | insertion | Frame_Shift_Ins | novel | c.1411_1412insTCTTGGCTAACTGCAACCTCCACTTCCTGGGATCA | p.Lys471IlefsTer54 | p.K471Ifs*54 | O75398 | protein_coding | | | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DEAF1 | insertion | Frame_Shift_Ins | novel | c.308_309insCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACA | p.Ala104LeufsTer50 | p.A104Lfs*50 | O75398 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
DEAF1 | deletion | Frame_Shift_Del | novel | c.907_916delNNNNNNNNNN | p.Lys304MetfsTer8 | p.K304Mfs*8 | O75398 | protein_coding | | | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
DEAF1 | insertion | Frame_Shift_Ins | novel | c.1543_1544insT | p.Cys515LeufsTer43 | p.C515Lfs*43 | O75398 | protein_coding | | | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEAF1 | insertion | In_Frame_Ins | novel | c.537_538insAGCTACTCG | p.Thr179_Pro180insSerTyrSer | p.T179_P180insSYS | O75398 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
DEAF1 | insertion | Frame_Shift_Ins | novel | c.535_536insGCGTGGTGGCAGGCGCCTGTAGTCCCATAGTC | p.Thr179SerfsTer105 | p.T179Sfs*105 | O75398 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
DEAF1 | SNV | Missense_Mutation | rs868811033 | c.364N>A | p.Ala122Thr | p.A122T | O75398 | protein_coding | tolerated(0.12) | benign(0.012) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |