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Gene: CYB5B |
Gene summary for CYB5B |
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Gene information | Species | Human | Gene symbol | CYB5B | Gene ID | 80777 |
Gene name | cytochrome b5 type B | |
Gene Alias | CYB5-M | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | J3KNF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80777 | CYB5B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.57e-04 | 4.39e-01 | -0.1808 |
80777 | CYB5B | HTA11_347_2000001011 | Human | Colorectum | AD | 9.96e-11 | 4.84e-01 | -0.1954 |
80777 | CYB5B | HTA11_411_2000001011 | Human | Colorectum | SER | 2.90e-04 | 8.71e-01 | -0.2602 |
80777 | CYB5B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.98e-05 | 3.08e-01 | -0.1464 |
80777 | CYB5B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.50e-04 | 4.49e-01 | -0.059 |
80777 | CYB5B | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.02e-04 | 7.12e-01 | -0.2061 |
80777 | CYB5B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.08e-08 | 5.60e-01 | 0.294 |
80777 | CYB5B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.19e-15 | 1.05e+00 | 0.281 |
80777 | CYB5B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.77e-13 | 6.59e-01 | 0.3859 |
80777 | CYB5B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.44e-02 | 4.75e-01 | 0.2585 |
80777 | CYB5B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.22e-06 | 4.84e-01 | 0.3005 |
80777 | CYB5B | A015-C-203 | Human | Colorectum | FAP | 4.79e-06 | -1.65e-01 | -0.1294 |
80777 | CYB5B | A002-C-201 | Human | Colorectum | FAP | 3.03e-04 | -2.20e-01 | 0.0324 |
80777 | CYB5B | A001-C-119 | Human | Colorectum | FAP | 3.82e-02 | -2.77e-01 | -0.1557 |
80777 | CYB5B | A001-C-108 | Human | Colorectum | FAP | 1.94e-04 | -2.45e-01 | -0.0272 |
80777 | CYB5B | A002-C-205 | Human | Colorectum | FAP | 1.56e-08 | -1.61e-01 | -0.1236 |
80777 | CYB5B | A015-C-006 | Human | Colorectum | FAP | 1.81e-05 | -1.77e-01 | -0.0994 |
80777 | CYB5B | A015-C-106 | Human | Colorectum | FAP | 1.47e-02 | -2.16e-01 | -0.0511 |
80777 | CYB5B | A002-C-114 | Human | Colorectum | FAP | 6.69e-06 | -2.18e-01 | -0.1561 |
80777 | CYB5B | A015-C-104 | Human | Colorectum | FAP | 5.18e-10 | -2.38e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000680511 | Liver | Cirrhotic | xenobiotic metabolic process | 43/4634 | 111/18723 | 7.51e-04 | 5.54e-03 | 43 |
GO:004620912 | Liver | Cirrhotic | nitric oxide metabolic process | 33/4634 | 81/18723 | 1.09e-03 | 7.59e-03 | 33 |
GO:000680912 | Liver | Cirrhotic | nitric oxide biosynthetic process | 31/4634 | 76/18723 | 1.49e-03 | 9.87e-03 | 31 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:002290022 | Liver | HCC | electron transport chain | 134/7958 | 175/18723 | 3.32e-20 | 4.68e-18 | 134 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:200105722 | Liver | HCC | reactive nitrogen species metabolic process | 51/7958 | 82/18723 | 2.50e-04 | 1.86e-03 | 51 |
GO:004620922 | Liver | HCC | nitric oxide metabolic process | 50/7958 | 81/18723 | 3.72e-04 | 2.56e-03 | 50 |
GO:000680922 | Liver | HCC | nitric oxide biosynthetic process | 46/7958 | 76/18723 | 1.15e-03 | 6.53e-03 | 46 |
GO:00714662 | Liver | HCC | cellular response to xenobiotic stimulus | 93/7958 | 177/18723 | 4.35e-03 | 1.89e-02 | 93 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:002290018 | Oral cavity | OSCC | electron transport chain | 126/7305 | 175/18723 | 6.65e-19 | 8.42e-17 | 126 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:000941018 | Oral cavity | OSCC | response to xenobiotic stimulus | 222/7305 | 462/18723 | 4.00e-05 | 3.48e-04 | 222 |
GO:000680915 | Oral cavity | OSCC | nitric oxide biosynthetic process | 41/7305 | 76/18723 | 5.78e-03 | 2.22e-02 | 41 |
GO:200105715 | Oral cavity | OSCC | reactive nitrogen species metabolic process | 43/7305 | 82/18723 | 9.20e-03 | 3.30e-02 | 43 |
GO:004620915 | Oral cavity | OSCC | nitric oxide metabolic process | 42/7305 | 81/18723 | 1.27e-02 | 4.24e-02 | 42 |
GO:002290019 | Oral cavity | LP | electron transport chain | 108/4623 | 175/18723 | 2.21e-25 | 9.90e-23 | 108 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYB5B | SNV | Missense_Mutation | novel | c.98N>T | p.Ala33Val | p.A33V | protein_coding | tolerated(0.16) | benign(0.162) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYB5B | SNV | Missense_Mutation | novel | c.397N>A | p.Ala133Thr | p.A133T | protein_coding | deleterious(0) | benign(0.241) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYB5B | SNV | Missense_Mutation | rs576407250 | c.388N>G | p.Ile130Val | p.I130V | protein_coding | tolerated(0.69) | benign(0.045) | TCGA-AX-A05U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CYB5B | SNV | Missense_Mutation | c.73N>G | p.Thr25Ala | p.T25A | protein_coding | tolerated(0.07) | benign(0.121) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CYB5B | SNV | Missense_Mutation | c.149A>G | p.Tyr50Cys | p.Y50C | protein_coding | deleterious(0) | benign(0.412) | TCGA-05-5423-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CYB5B | insertion | Frame_Shift_Ins | novel | c.188_189insAG | p.Val65ArgfsTer9 | p.V65Rfs*9 | protein_coding | TCGA-85-8276-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |||
CYB5B | SNV | Missense_Mutation | novel | c.292G>A | p.Asp98Asn | p.D98N | protein_coding | deleterious(0.02) | possibly_damaging(0.721) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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