![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CTSF |
Gene summary for CTSF |
![]() |
Gene information | Species | Human | Gene symbol | CTSF | Gene ID | 8722 |
Gene name | cathepsin F | |
Gene Alias | CATSF | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9UBX1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8722 | CTSF | LZE4T | Human | Esophagus | ESCC | 2.92e-04 | -7.06e-02 | 0.0811 |
8722 | CTSF | LZE24T | Human | Esophagus | ESCC | 3.67e-19 | 8.74e-01 | 0.0596 |
8722 | CTSF | P1T-E | Human | Esophagus | ESCC | 9.89e-04 | 5.46e-01 | 0.0875 |
8722 | CTSF | P2T-E | Human | Esophagus | ESCC | 1.16e-21 | 1.63e-01 | 0.1177 |
8722 | CTSF | P4T-E | Human | Esophagus | ESCC | 5.48e-11 | 1.72e-01 | 0.1323 |
8722 | CTSF | P8T-E | Human | Esophagus | ESCC | 2.15e-48 | 1.12e+00 | 0.0889 |
8722 | CTSF | P9T-E | Human | Esophagus | ESCC | 1.04e-06 | 1.65e-01 | 0.1131 |
8722 | CTSF | P10T-E | Human | Esophagus | ESCC | 3.84e-16 | 2.96e-01 | 0.116 |
8722 | CTSF | P11T-E | Human | Esophagus | ESCC | 1.97e-13 | 9.63e-01 | 0.1426 |
8722 | CTSF | P12T-E | Human | Esophagus | ESCC | 9.31e-22 | 4.44e-01 | 0.1122 |
8722 | CTSF | P15T-E | Human | Esophagus | ESCC | 2.12e-10 | 3.39e-01 | 0.1149 |
8722 | CTSF | P16T-E | Human | Esophagus | ESCC | 5.69e-52 | 1.25e+00 | 0.1153 |
8722 | CTSF | P20T-E | Human | Esophagus | ESCC | 4.88e-03 | 1.28e-01 | 0.1124 |
8722 | CTSF | P21T-E | Human | Esophagus | ESCC | 3.25e-17 | 1.17e-01 | 0.1617 |
8722 | CTSF | P22T-E | Human | Esophagus | ESCC | 4.90e-25 | 5.05e-01 | 0.1236 |
8722 | CTSF | P23T-E | Human | Esophagus | ESCC | 5.60e-18 | 6.61e-01 | 0.108 |
8722 | CTSF | P24T-E | Human | Esophagus | ESCC | 9.72e-14 | 5.39e-02 | 0.1287 |
8722 | CTSF | P26T-E | Human | Esophagus | ESCC | 1.45e-35 | 7.65e-01 | 0.1276 |
8722 | CTSF | P27T-E | Human | Esophagus | ESCC | 3.45e-13 | 3.23e-01 | 0.1055 |
8722 | CTSF | P28T-E | Human | Esophagus | ESCC | 6.50e-09 | 5.07e-02 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001988418 | Prostate | Tumor | antigen processing and presentation of exogenous antigen | 17/3246 | 47/18723 | 1.55e-03 | 9.54e-03 | 17 |
GO:000247818 | Prostate | Tumor | antigen processing and presentation of exogenous peptide antigen | 14/3246 | 38/18723 | 3.24e-03 | 1.69e-02 | 14 |
GO:0019882112 | Thyroid | PTC | antigen processing and presentation | 57/5968 | 106/18723 | 2.40e-06 | 3.17e-05 | 57 |
GO:0002478112 | Thyroid | PTC | antigen processing and presentation of exogenous peptide antigen | 25/5968 | 38/18723 | 1.80e-05 | 1.86e-04 | 25 |
GO:0048002112 | Thyroid | PTC | antigen processing and presentation of peptide antigen | 36/5968 | 62/18723 | 1.84e-05 | 1.89e-04 | 36 |
GO:0019884112 | Thyroid | PTC | antigen processing and presentation of exogenous antigen | 29/5968 | 47/18723 | 2.44e-05 | 2.40e-04 | 29 |
GO:0002504110 | Thyroid | PTC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 21/5968 | 36/18723 | 9.36e-04 | 5.68e-03 | 21 |
GO:0019886111 | Thyroid | PTC | antigen processing and presentation of exogenous peptide antigen via MHC class II | 18/5968 | 30/18723 | 1.38e-03 | 7.74e-03 | 18 |
GO:0002495110 | Thyroid | PTC | antigen processing and presentation of peptide antigen via MHC class II | 19/5968 | 34/18723 | 3.21e-03 | 1.57e-02 | 19 |
GO:001988229 | Thyroid | ATC | antigen processing and presentation | 57/6293 | 106/18723 | 1.48e-05 | 1.39e-04 | 57 |
GO:004800228 | Thyroid | ATC | antigen processing and presentation of peptide antigen | 34/6293 | 62/18723 | 4.66e-04 | 2.74e-03 | 34 |
GO:000247831 | Thyroid | ATC | antigen processing and presentation of exogenous peptide antigen | 23/6293 | 38/18723 | 6.05e-04 | 3.44e-03 | 23 |
GO:001988431 | Thyroid | ATC | antigen processing and presentation of exogenous antigen | 27/6293 | 47/18723 | 6.69e-04 | 3.77e-03 | 27 |
GO:000250423 | Thyroid | ATC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 19/6293 | 36/18723 | 1.37e-02 | 4.77e-02 | 19 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0421011 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa042102 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa042103 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
hsa0421018 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0421019 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0421026 | Oral cavity | LP | Apoptosis | 65/2418 | 136/8465 | 1.33e-06 | 1.48e-05 | 9.53e-06 | 65 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0421036 | Oral cavity | LP | Apoptosis | 65/2418 | 136/8465 | 1.33e-06 | 1.48e-05 | 9.53e-06 | 65 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSF | SNV | Missense_Mutation | c.1360G>A | p.Gly454Ser | p.G454S | Q9UBX1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A7-A26H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | |
CTSF | SNV | Missense_Mutation | c.344G>A | p.Gly115Glu | p.G115E | Q9UBX1 | protein_coding | deleterious(0.01) | benign(0.212) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CTSF | SNV | Missense_Mutation | c.295N>A | p.Val99Met | p.V99M | Q9UBX1 | protein_coding | tolerated(0.21) | benign(0.24) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
CTSF | insertion | Frame_Shift_Ins | novel | c.1008_1009insCCAGTAACAAGGGAGTTCCCTTCCTCCAGAGACCT | p.Leu337ProfsTer21 | p.L337Pfs*21 | Q9UBX1 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CTSF | SNV | Missense_Mutation | novel | c.1146N>C | p.Glu382Asp | p.E382D | Q9UBX1 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CTSF | SNV | Missense_Mutation | c.511A>G | p.Asn171Asp | p.N171D | Q9UBX1 | protein_coding | tolerated(0.19) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CTSF | SNV | Missense_Mutation | rs142782021 | c.614N>A | p.Arg205Gln | p.R205Q | Q9UBX1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CTSF | SNV | Missense_Mutation | novel | c.1038G>T | p.Lys346Asn | p.K346N | Q9UBX1 | protein_coding | deleterious(0.05) | benign(0.424) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTSF | SNV | Missense_Mutation | rs768809245 | c.1442C>T | p.Ala481Val | p.A481V | Q9UBX1 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CTSF | SNV | Missense_Mutation | c.1009T>A | p.Leu337Met | p.L337M | Q9UBX1 | protein_coding | deleterious(0.04) | benign(0.341) | TCGA-F4-6569-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8722 | CTSF | DRUGGABLE GENOME, PROTEASE, ENZYME | PMID27998201-Compound-12 | |||
8722 | CTSF | DRUGGABLE GENOME, PROTEASE, ENZYME | PMID27998201-Compound-5 | |||
8722 | CTSF | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103149 | ||
8722 | CTSF | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 405067337 |
Page: 1 |