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Gene: CTSC |
Gene summary for CTSC |
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Gene information | Species | Human | Gene symbol | CTSC | Gene ID | 1075 |
Gene name | cathepsin C | |
Gene Alias | CPPI | |
Cytomap | 11q14.2 | |
Gene Type | protein-coding | GO ID | GO:0001774 | UniProtAcc | P53634 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1075 | CTSC | CA_HPV_1 | Human | Cervix | CC | 1.36e-26 | 7.13e-01 | 0.0264 |
1075 | CTSC | N_HPV_2 | Human | Cervix | N_HPV | 5.40e-07 | 3.76e-01 | -0.0131 |
1075 | CTSC | CCII_1 | Human | Cervix | CC | 2.04e-11 | -5.44e-01 | 0.3249 |
1075 | CTSC | Tumor | Human | Cervix | CC | 2.05e-40 | 8.50e-01 | 0.1241 |
1075 | CTSC | sample3 | Human | Cervix | CC | 1.21e-35 | 7.05e-01 | 0.1387 |
1075 | CTSC | L1 | Human | Cervix | CC | 2.30e-10 | 4.22e-01 | 0.0802 |
1075 | CTSC | T3 | Human | Cervix | CC | 2.76e-28 | 7.18e-01 | 0.1389 |
1075 | CTSC | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.51e-04 | 4.89e-01 | -0.0811 |
1075 | CTSC | HTA11_78_2000001011 | Human | Colorectum | AD | 8.71e-03 | 3.79e-01 | -0.1088 |
1075 | CTSC | HTA11_347_2000001011 | Human | Colorectum | AD | 2.30e-10 | 4.51e-01 | -0.1954 |
1075 | CTSC | HTA11_83_2000001011 | Human | Colorectum | SER | 3.48e-03 | 4.28e-01 | -0.1526 |
1075 | CTSC | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.88e-02 | 3.21e-01 | -0.059 |
1075 | CTSC | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.70e-04 | 1.54e-01 | 0.0674 |
1075 | CTSC | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.16e-02 | 4.25e-01 | -0.0124 |
1075 | CTSC | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.07e-05 | 3.09e-01 | 0.294 |
1075 | CTSC | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.38e-04 | 3.94e-01 | 0.281 |
1075 | CTSC | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.43e-09 | 4.49e-01 | 0.3859 |
1075 | CTSC | A015-C-203 | Human | Colorectum | FAP | 1.82e-03 | -1.57e-01 | -0.1294 |
1075 | CTSC | A002-C-114 | Human | Colorectum | FAP | 5.98e-04 | -1.78e-01 | -0.1561 |
1075 | CTSC | A018-E-020 | Human | Colorectum | FAP | 2.14e-02 | -1.63e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005072921 | Cervix | N_HPV | positive regulation of inflammatory response | 16/534 | 142/18723 | 3.03e-06 | 1.28e-04 | 16 |
GO:190336225 | Cervix | N_HPV | regulation of cellular protein catabolic process | 22/534 | 255/18723 | 4.31e-06 | 1.66e-04 | 22 |
GO:004217625 | Cervix | N_HPV | regulation of protein catabolic process | 28/534 | 391/18723 | 8.41e-06 | 2.92e-04 | 28 |
GO:200123524 | Cervix | N_HPV | positive regulation of apoptotic signaling pathway | 14/534 | 126/18723 | 1.47e-05 | 4.55e-04 | 14 |
GO:190336425 | Cervix | N_HPV | positive regulation of cellular protein catabolic process | 15/534 | 155/18723 | 3.84e-05 | 9.41e-04 | 15 |
GO:00017741 | Cervix | N_HPV | microglial cell activation | 8/534 | 47/18723 | 4.90e-05 | 1.13e-03 | 8 |
GO:00430302 | Cervix | N_HPV | regulation of macrophage activation | 9/534 | 61/18723 | 5.41e-05 | 1.22e-03 | 9 |
GO:000190911 | Cervix | N_HPV | leukocyte mediated cytotoxicity | 13/534 | 124/18723 | 5.46e-05 | 1.22e-03 | 13 |
GO:004573225 | Cervix | N_HPV | positive regulation of protein catabolic process | 18/534 | 231/18723 | 1.19e-04 | 2.31e-03 | 18 |
GO:003134921 | Cervix | N_HPV | positive regulation of defense response | 20/534 | 278/18723 | 1.51e-04 | 2.77e-03 | 20 |
GO:190305025 | Cervix | N_HPV | regulation of proteolysis involved in cellular protein catabolic process | 17/534 | 221/18723 | 2.13e-04 | 3.55e-03 | 17 |
GO:000989615 | Cervix | N_HPV | positive regulation of catabolic process | 28/534 | 492/18723 | 4.43e-04 | 6.10e-03 | 28 |
GO:003133115 | Cervix | N_HPV | positive regulation of cellular catabolic process | 25/534 | 427/18723 | 5.88e-04 | 7.74e-03 | 25 |
GO:000756824 | Cervix | N_HPV | aging | 21/534 | 339/18723 | 7.77e-04 | 9.73e-03 | 21 |
GO:0043032 | Cervix | N_HPV | positive regulation of macrophage activation | 5/534 | 30/18723 | 1.46e-03 | 1.55e-02 | 5 |
GO:190305214 | Cervix | N_HPV | positive regulation of proteolysis involved in cellular protein catabolic process | 11/534 | 133/18723 | 1.51e-03 | 1.58e-02 | 11 |
GO:1903978 | Cervix | N_HPV | regulation of microglial cell activation | 4/534 | 19/18723 | 1.80e-03 | 1.81e-02 | 4 |
GO:0150077 | Cervix | N_HPV | regulation of neuroinflammatory response | 5/534 | 40/18723 | 5.35e-03 | 3.84e-02 | 5 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421042 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa0421052 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa0421010 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa0421015 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa0421024 | Endometrium | EEC | Apoptosis | 31/1237 | 136/8465 | 6.72e-03 | 3.25e-02 | 2.42e-02 | 31 |
hsa0421034 | Endometrium | EEC | Apoptosis | 31/1237 | 136/8465 | 6.72e-03 | 3.25e-02 | 2.42e-02 | 31 |
hsa0421020 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa04210110 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSC | SNV | Missense_Mutation | novel | c.656N>T | p.Pro219Leu | p.P219L | P53634 | protein_coding | deleterious(0.03) | possibly_damaging(0.477) | TCGA-EW-A2FR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | SD |
CTSC | SNV | Missense_Mutation | c.1106C>A | p.Pro369His | p.P369H | P53634 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CTSC | SNV | Missense_Mutation | c.959N>A | p.Ala320Asp | p.A320D | P53634 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CTSC | SNV | Missense_Mutation | c.680N>C | p.Lys227Thr | p.K227T | P53634 | protein_coding | tolerated(0.44) | benign(0.117) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CTSC | SNV | Missense_Mutation | rs370851747 | c.731N>G | p.Asn244Ser | p.N244S | P53634 | protein_coding | tolerated(0.09) | benign(0.237) | TCGA-AY-4071-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTSC | SNV | Missense_Mutation | novel | c.611N>A | p.Arg204Lys | p.R204K | P53634 | protein_coding | tolerated(0.08) | benign(0.018) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CTSC | SNV | Missense_Mutation | rs754353507 | c.1318N>T | p.Arg440Trp | p.R440W | P53634 | protein_coding | deleterious(0.05) | possibly_damaging(0.736) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTSC | SNV | Missense_Mutation | c.551N>T | p.Ser184Phe | p.S184F | P53634 | protein_coding | deleterious(0.01) | possibly_damaging(0.903) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CTSC | SNV | Missense_Mutation | c.460N>A | p.Ala154Thr | p.A154T | P53634 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CTSC | insertion | Frame_Shift_Ins | novel | c.1280dupA | p.Asn427LysfsTer9 | p.N427Kfs*9 | P53634 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 252166823 | ||
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | PROGESTERONE | PROGESTERONE | 17916955 | |
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | PENTOSAN POLYSULFATE | 17826736 | ||
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | GSK2793660 | |||
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | CALCIUM GLUCONATE | 18822840 | ||
1075 | CTSC | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 328083514 |
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