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Gene: CSTB |
Gene summary for CSTB |
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Gene information | Species | Human | Gene symbol | CSTB | Gene ID | 1476 |
Gene name | cystatin B | |
Gene Alias | CPI-B | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P04080 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1476 | CSTB | GSM4909280 | Human | Breast | Precancer | 1.28e-04 | -6.94e-01 | 0.0305 |
1476 | CSTB | GSM4909282 | Human | Breast | IDC | 5.17e-116 | 1.01e+00 | -0.0288 |
1476 | CSTB | GSM4909285 | Human | Breast | IDC | 2.08e-116 | 9.95e-01 | 0.21 |
1476 | CSTB | GSM4909286 | Human | Breast | IDC | 7.60e-13 | -1.55e-01 | 0.1081 |
1476 | CSTB | GSM4909287 | Human | Breast | IDC | 8.02e-20 | 4.70e-01 | 0.2057 |
1476 | CSTB | GSM4909290 | Human | Breast | IDC | 6.81e-27 | 6.10e-01 | 0.2096 |
1476 | CSTB | GSM4909293 | Human | Breast | IDC | 4.44e-03 | 2.05e-01 | 0.1581 |
1476 | CSTB | GSM4909294 | Human | Breast | IDC | 4.39e-17 | -6.02e-01 | 0.2022 |
1476 | CSTB | GSM4909296 | Human | Breast | IDC | 9.43e-06 | -2.48e-01 | 0.1524 |
1476 | CSTB | GSM4909297 | Human | Breast | IDC | 3.56e-13 | -2.40e-01 | 0.1517 |
1476 | CSTB | GSM4909304 | Human | Breast | IDC | 3.25e-03 | 1.98e-01 | 0.1636 |
1476 | CSTB | GSM4909305 | Human | Breast | IDC | 1.55e-03 | -1.31e-01 | 0.0436 |
1476 | CSTB | GSM4909306 | Human | Breast | IDC | 1.55e-05 | -2.30e-01 | 0.1564 |
1476 | CSTB | GSM4909308 | Human | Breast | IDC | 7.73e-05 | 2.51e-01 | 0.158 |
1476 | CSTB | GSM4909311 | Human | Breast | IDC | 1.03e-34 | -2.23e-01 | 0.1534 |
1476 | CSTB | GSM4909312 | Human | Breast | IDC | 3.66e-02 | -1.66e-01 | 0.1552 |
1476 | CSTB | GSM4909317 | Human | Breast | IDC | 4.86e-12 | -4.84e-01 | 0.1355 |
1476 | CSTB | GSM4909319 | Human | Breast | IDC | 2.56e-51 | -7.28e-01 | 0.1563 |
1476 | CSTB | GSM4909321 | Human | Breast | IDC | 1.58e-07 | -1.86e-01 | 0.1559 |
1476 | CSTB | brca1 | Human | Breast | Precancer | 1.06e-21 | 5.36e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
GO:00525481 | Colorectum | SER | regulation of endopeptidase activity | 103/2897 | 432/18723 | 2.86e-06 | 1.16e-04 | 103 |
GO:0051346 | Colorectum | SER | negative regulation of hydrolase activity | 82/2897 | 379/18723 | 8.19e-04 | 1.01e-02 | 82 |
GO:0010466 | Colorectum | SER | negative regulation of peptidase activity | 57/2897 | 262/18723 | 4.15e-03 | 3.38e-02 | 57 |
GO:00525472 | Colorectum | MSS | regulation of peptidase activity | 130/3467 | 461/18723 | 1.81e-07 | 8.13e-06 | 130 |
GO:00525482 | Colorectum | MSS | regulation of endopeptidase activity | 117/3467 | 432/18723 | 6.25e-06 | 1.65e-04 | 117 |
GO:00458612 | Colorectum | MSS | negative regulation of proteolysis | 97/3467 | 351/18723 | 1.57e-05 | 3.54e-04 | 97 |
GO:00513461 | Colorectum | MSS | negative regulation of hydrolase activity | 92/3467 | 379/18723 | 2.85e-03 | 2.22e-02 | 92 |
GO:00458613 | Colorectum | MSI-H | negative regulation of proteolysis | 55/1319 | 351/18723 | 1.75e-08 | 1.98e-06 | 55 |
GO:00525473 | Colorectum | MSI-H | regulation of peptidase activity | 66/1319 | 461/18723 | 2.63e-08 | 2.81e-06 | 66 |
GO:00525483 | Colorectum | MSI-H | regulation of endopeptidase activity | 60/1319 | 432/18723 | 3.29e-07 | 2.57e-05 | 60 |
GO:00513462 | Colorectum | MSI-H | negative regulation of hydrolase activity | 48/1319 | 379/18723 | 5.58e-05 | 1.92e-03 | 48 |
GO:00104661 | Colorectum | MSI-H | negative regulation of peptidase activity | 35/1319 | 262/18723 | 1.95e-04 | 5.30e-03 | 35 |
GO:0010951 | Colorectum | MSI-H | negative regulation of endopeptidase activity | 33/1319 | 252/18723 | 4.22e-04 | 9.23e-03 | 33 |
GO:0008344 | Colorectum | MSI-H | adult locomotory behavior | 13/1319 | 71/18723 | 1.24e-03 | 2.00e-02 | 13 |
GO:005254716 | Endometrium | AEH | regulation of peptidase activity | 85/2100 | 461/18723 | 2.47e-06 | 7.11e-05 | 85 |
GO:005254816 | Endometrium | AEH | regulation of endopeptidase activity | 76/2100 | 432/18723 | 4.42e-05 | 7.43e-04 | 76 |
GO:004586116 | Endometrium | AEH | negative regulation of proteolysis | 63/2100 | 351/18723 | 1.07e-04 | 1.53e-03 | 63 |
GO:005134610 | Endometrium | AEH | negative regulation of hydrolase activity | 65/2100 | 379/18723 | 3.18e-04 | 3.57e-03 | 65 |
GO:001046610 | Endometrium | AEH | negative regulation of peptidase activity | 43/2100 | 262/18723 | 6.78e-03 | 3.95e-02 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSTB | insertion | Nonsense_Mutation | novel | c.190_191insCCCCGTTTGTAACGCGGGCCCCGTCCTGAA | p.Phe64delinsSerProPheValThrArgAlaProSerTerIle | p.F64delinsSPFVTRAPS*I | P04080 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
CSTB | SNV | Missense_Mutation | c.226N>A | p.Glu76Lys | p.E76K | P04080 | protein_coding | tolerated(0.13) | benign(0.132) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | c.215N>G | p.Ser72Cys | p.S72C | P04080 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | novel | c.107N>A | p.Pro36His | p.P36H | P04080 | protein_coding | tolerated(0.07) | possibly_damaging(0.8) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | novel | c.87G>T | p.Glu29Asp | p.E29D | P04080 | protein_coding | deleterious(0.01) | benign(0.134) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | c.227N>G | p.Glu76Gly | p.E76G | P04080 | protein_coding | tolerated(0.05) | possibly_damaging(0.825) | TCGA-ED-A4XI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | novel | c.217N>G | p.Leu73Val | p.L73V | P04080 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | c.172C>T | p.His58Tyr | p.H58Y | P04080 | protein_coding | tolerated(0.14) | possibly_damaging(0.664) | TCGA-EJ-5516-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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