![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CPB2 |
Gene summary for CPB2 |
![]() |
Gene information | Species | Human | Gene symbol | CPB2 | Gene ID | 1361 |
Gene name | carboxypeptidase B2 | |
Gene Alias | CPU | |
Cytomap | 13q14.13 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | A0A087WSY5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1361 | CPB2 | NAFLD1 | Human | Liver | NAFLD | 1.08e-04 | 8.12e-01 | -0.04 |
1361 | CPB2 | S42 | Human | Liver | HCC | 1.77e-02 | -6.20e-01 | -0.0103 |
1361 | CPB2 | S43 | Human | Liver | Cirrhotic | 1.22e-32 | -3.61e-01 | -0.0187 |
1361 | CPB2 | HCC1_Meng | Human | Liver | HCC | 9.11e-81 | -3.13e-01 | 0.0246 |
1361 | CPB2 | HCC2_Meng | Human | Liver | HCC | 8.90e-40 | -8.61e-01 | 0.0107 |
1361 | CPB2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.46e-07 | -7.49e-02 | 0.0202 |
1361 | CPB2 | cirrhotic2 | Human | Liver | Cirrhotic | 4.30e-09 | 1.31e-01 | 0.0201 |
1361 | CPB2 | cirrhotic3 | Human | Liver | Cirrhotic | 2.33e-10 | -5.23e-01 | 0.0215 |
1361 | CPB2 | HCC1 | Human | Liver | HCC | 2.34e-12 | 5.74e+00 | 0.5336 |
1361 | CPB2 | HCC2 | Human | Liver | HCC | 6.23e-20 | 4.10e+00 | 0.5341 |
1361 | CPB2 | HCC5 | Human | Liver | HCC | 7.42e-12 | 1.23e+00 | 0.4932 |
1361 | CPB2 | Pt13.a | Human | Liver | HCC | 1.25e-02 | -1.83e-01 | 0.021 |
1361 | CPB2 | Pt13.b | Human | Liver | HCC | 4.42e-27 | -3.44e-01 | 0.0251 |
1361 | CPB2 | Pt13.c | Human | Liver | HCC | 1.53e-06 | -6.12e-01 | 0.0076 |
1361 | CPB2 | Pt14.a | Human | Liver | HCC | 4.37e-02 | -1.26e-01 | 0.0169 |
1361 | CPB2 | Pt14.b | Human | Liver | HCC | 2.82e-04 | -2.26e-01 | 0.018 |
1361 | CPB2 | Pt14.d | Human | Liver | HCC | 2.12e-06 | -3.72e-01 | 0.0143 |
1361 | CPB2 | S014 | Human | Liver | HCC | 1.86e-10 | 1.17e+00 | 0.2254 |
1361 | CPB2 | S015 | Human | Liver | HCC | 7.99e-10 | 1.38e+00 | 0.2375 |
1361 | CPB2 | S016 | Human | Liver | HCC | 1.08e-13 | 1.46e+00 | 0.2243 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00097467 | Liver | NAFLD | response to hexose | 36/1882 | 219/18723 | 2.14e-03 | 2.08e-02 | 36 |
GO:0032102 | Liver | NAFLD | negative regulation of response to external stimulus | 60/1882 | 420/18723 | 3.34e-03 | 2.93e-02 | 60 |
GO:0010755 | Liver | NAFLD | regulation of plasminogen activation | 5/1882 | 13/18723 | 6.58e-03 | 4.69e-02 | 5 |
GO:00016786 | Liver | NAFLD | cellular glucose homeostasis | 28/1882 | 172/18723 | 7.15e-03 | 4.96e-02 | 28 |
GO:000188912 | Liver | Cirrhotic | liver development | 81/4634 | 147/18723 | 2.99e-15 | 3.35e-13 | 81 |
GO:006100812 | Liver | Cirrhotic | hepaticobiliary system development | 82/4634 | 150/18723 | 3.72e-15 | 4.09e-13 | 82 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:004586112 | Liver | Cirrhotic | negative regulation of proteolysis | 136/4634 | 351/18723 | 3.46e-09 | 1.42e-07 | 136 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:000974312 | Liver | Cirrhotic | response to carbohydrate | 101/4634 | 253/18723 | 6.24e-08 | 1.92e-06 | 101 |
GO:000941012 | Liver | Cirrhotic | response to xenobiotic stimulus | 165/4634 | 462/18723 | 6.82e-08 | 2.09e-06 | 165 |
GO:003428412 | Liver | Cirrhotic | response to monosaccharide | 90/4634 | 225/18723 | 2.87e-07 | 7.01e-06 | 90 |
GO:190303611 | Liver | Cirrhotic | positive regulation of response to wounding | 38/4634 | 72/18723 | 2.98e-07 | 7.18e-06 | 38 |
GO:009030311 | Liver | Cirrhotic | positive regulation of wound healing | 33/4634 | 59/18723 | 3.00e-07 | 7.21e-06 | 33 |
GO:00316391 | Liver | Cirrhotic | plasminogen activation | 18/4634 | 24/18723 | 3.24e-07 | 7.75e-06 | 18 |
GO:004873212 | Liver | Cirrhotic | gland development | 154/4634 | 436/18723 | 4.03e-07 | 9.42e-06 | 154 |
GO:000974612 | Liver | Cirrhotic | response to hexose | 86/4634 | 219/18723 | 1.30e-06 | 2.59e-05 | 86 |
GO:006104112 | Liver | Cirrhotic | regulation of wound healing | 58/4634 | 134/18723 | 1.95e-06 | 3.65e-05 | 58 |
GO:00301931 | Liver | Cirrhotic | regulation of blood coagulation | 34/4634 | 66/18723 | 2.55e-06 | 4.63e-05 | 34 |
GO:00094087 | Liver | Cirrhotic | response to heat | 49/4634 | 110/18723 | 4.47e-06 | 7.42e-05 | 49 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPB2 | SNV | Missense_Mutation | rs368766293 | c.157N>T | p.Leu53Phe | p.L53F | Q96IY4 | protein_coding | tolerated(0.95) | probably_damaging(1) | TCGA-A7-A13E-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | bevacizumab | PD |
CPB2 | SNV | Missense_Mutation | c.1096C>G | p.Pro366Ala | p.P366A | Q96IY4 | protein_coding | tolerated(0.76) | probably_damaging(0.968) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
CPB2 | SNV | Missense_Mutation | c.192N>C | p.Lys64Asn | p.K64N | Q96IY4 | protein_coding | tolerated(0.37) | probably_damaging(0.956) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPB2 | SNV | Missense_Mutation | novel | c.731T>G | p.Phe244Cys | p.F244C | Q96IY4 | protein_coding | tolerated(0.19) | possibly_damaging(0.523) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CPB2 | SNV | Missense_Mutation | novel | c.1192G>A | p.Glu398Lys | p.E398K | Q96IY4 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
CPB2 | SNV | Missense_Mutation | rs199530853 | c.232G>A | p.Asp78Asn | p.D78N | Q96IY4 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-DR-A0ZL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CPB2 | SNV | Missense_Mutation | c.1067N>A | p.Gly356Asp | p.G356D | Q96IY4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CPB2 | SNV | Missense_Mutation | rs770303867 | c.325N>A | p.Asp109Asn | p.D109N | Q96IY4 | protein_coding | tolerated(0.14) | benign(0.042) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CPB2 | SNV | Missense_Mutation | c.1067G>A | p.Gly356Asp | p.G356D | Q96IY4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPB2 | SNV | Missense_Mutation | novel | c.491N>T | p.Ser164Phe | p.S164F | Q96IY4 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | UK-396082 | UK-396,082 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166824 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | DS-1040 | |||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | SAR-126119 | |||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166875 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166857 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166856 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | C5A | 14525995 | ||
1361 | CPB2 | DRUGGABLE GENOME, ENZYME, PROTEASE | SAR-104772 |
Page: 1 |