Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CKAP5_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CKAP5_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CKAP5_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CKAP5_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CKAP5_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CKAP5_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00311128 | Esophagus | ESCC | positive regulation of microtubule polymerization or depolymerization | 29/8552 | 37/18723 | 4.97e-05 | 3.86e-04 | 29 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00311168 | Esophagus | ESCC | positive regulation of microtubule polymerization | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:00467856 | Esophagus | ESCC | microtubule polymerization | 55/8552 | 83/18723 | 1.21e-04 | 8.31e-04 | 55 |
GO:00070205 | Esophagus | ESCC | microtubule nucleation | 27/8552 | 35/18723 | 1.48e-04 | 9.88e-04 | 27 |
GO:00311104 | Esophagus | ESCC | regulation of microtubule polymerization or depolymerization | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
GO:00109684 | Esophagus | ESCC | regulation of microtubule nucleation | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
GO:00311138 | Esophagus | ESCC | regulation of microtubule polymerization | 36/8552 | 55/18723 | 2.43e-03 | 1.06e-02 | 36 |
GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
GO:00071636 | Liver | NAFLD | establishment or maintenance of cell polarity | 46/1882 | 218/18723 | 8.80e-07 | 4.60e-05 | 46 |
GO:19029037 | Liver | NAFLD | regulation of supramolecular fiber organization | 66/1882 | 383/18723 | 8.97e-06 | 2.96e-04 | 66 |
GO:19029057 | Liver | NAFLD | positive regulation of supramolecular fiber organization | 40/1882 | 209/18723 | 4.88e-05 | 1.15e-03 | 40 |
GO:00432547 | Liver | NAFLD | regulation of protein-containing complex assembly | 66/1882 | 428/18723 | 2.83e-04 | 4.53e-03 | 66 |
GO:00512587 | Liver | NAFLD | protein polymerization | 49/1882 | 297/18723 | 3.54e-04 | 5.36e-03 | 49 |
GO:00322717 | Liver | NAFLD | regulation of protein polymerization | 38/1882 | 233/18723 | 1.90e-03 | 1.93e-02 | 38 |
GO:00514957 | Liver | NAFLD | positive regulation of cytoskeleton organization | 37/1882 | 226/18723 | 2.02e-03 | 2.00e-02 | 37 |
GO:00322737 | Liver | NAFLD | positive regulation of protein polymerization | 25/1882 | 138/18723 | 2.61e-03 | 2.41e-02 | 25 |
GO:00512366 | Liver | NAFLD | establishment of RNA localization | 28/1882 | 166/18723 | 4.35e-03 | 3.57e-02 | 28 |
GO:00064037 | Liver | NAFLD | RNA localization | 32/1882 | 201/18723 | 5.96e-03 | 4.48e-02 | 32 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CKAP5 | SNV | Missense_Mutation | | c.3470N>G | p.Ser1157Cys | p.S1157C | Q14008 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CKAP5 | SNV | Missense_Mutation | novel | c.4878G>C | p.Gln1626His | p.Q1626H | Q14008 | protein_coding | tolerated(0.07) | possibly_damaging(0.556) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
CKAP5 | SNV | Missense_Mutation | | c.5440G>A | p.Glu1814Lys | p.E1814K | Q14008 | protein_coding | tolerated(0.19) | probably_damaging(0.98) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CKAP5 | SNV | Missense_Mutation | | c.5491G>A | p.Asp1831Asn | p.D1831N | Q14008 | protein_coding | tolerated(0.06) | probably_damaging(0.989) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
CKAP5 | SNV | Missense_Mutation | novel | c.1116N>T | p.Glu372Asp | p.E372D | Q14008 | protein_coding | tolerated(0.05) | probably_damaging(0.971) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CKAP5 | SNV | Missense_Mutation | | c.5737C>G | p.Pro1913Ala | p.P1913A | Q14008 | protein_coding | tolerated(0.64) | benign(0.015) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CKAP5 | SNV | Missense_Mutation | | c.5000N>T | p.Ser1667Phe | p.S1667F | Q14008 | protein_coding | deleterious(0.04) | possibly_damaging(0.603) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
CKAP5 | SNV | Missense_Mutation | novel | c.2166N>A | p.Met722Ile | p.M722I | Q14008 | protein_coding | tolerated(0.17) | benign(0) | TCGA-AR-A2LR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CKAP5 | SNV | Missense_Mutation | | c.4459N>T | p.Asp1487Tyr | p.D1487Y | Q14008 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CKAP5 | SNV | Missense_Mutation | | c.42N>C | p.Gln14His | p.Q14H | Q14008 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |