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Gene: CISD1 |
Gene summary for CISD1 |
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Gene information | Species | Human | Gene symbol | CISD1 | Gene ID | 55847 |
Gene name | CDGSH iron sulfur domain 1 | |
Gene Alias | C10orf70 | |
Cytomap | 10q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | A0A024QZN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55847 | CISD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.16e-06 | 3.09e-01 | -0.1954 |
55847 | CISD1 | A015-C-203 | Human | Colorectum | FAP | 2.52e-11 | -2.74e-01 | -0.1294 |
55847 | CISD1 | A002-C-201 | Human | Colorectum | FAP | 2.96e-02 | -2.12e-01 | 0.0324 |
55847 | CISD1 | A001-C-119 | Human | Colorectum | FAP | 2.01e-02 | -2.85e-01 | -0.1557 |
55847 | CISD1 | A001-C-108 | Human | Colorectum | FAP | 3.16e-07 | -2.16e-01 | -0.0272 |
55847 | CISD1 | A002-C-205 | Human | Colorectum | FAP | 2.32e-04 | -2.54e-01 | -0.1236 |
55847 | CISD1 | A015-C-106 | Human | Colorectum | FAP | 1.63e-06 | -2.35e-01 | -0.0511 |
55847 | CISD1 | A002-C-114 | Human | Colorectum | FAP | 8.27e-03 | -2.42e-01 | -0.1561 |
55847 | CISD1 | A015-C-104 | Human | Colorectum | FAP | 1.25e-09 | -1.91e-01 | -0.1899 |
55847 | CISD1 | A001-C-014 | Human | Colorectum | FAP | 4.86e-04 | -1.97e-01 | 0.0135 |
55847 | CISD1 | A002-C-016 | Human | Colorectum | FAP | 1.46e-05 | -2.12e-01 | 0.0521 |
55847 | CISD1 | A001-C-203 | Human | Colorectum | FAP | 1.16e-03 | -1.63e-01 | -0.0481 |
55847 | CISD1 | A002-C-116 | Human | Colorectum | FAP | 1.41e-12 | -2.41e-01 | -0.0452 |
55847 | CISD1 | A014-C-008 | Human | Colorectum | FAP | 1.70e-02 | -2.89e-01 | -0.191 |
55847 | CISD1 | A018-E-020 | Human | Colorectum | FAP | 4.88e-03 | -2.31e-01 | -0.2034 |
55847 | CISD1 | F034 | Human | Colorectum | FAP | 4.50e-06 | -2.32e-01 | -0.0665 |
55847 | CISD1 | F072B | Human | Colorectum | FAP | 7.21e-03 | -1.06e-01 | 0.257 |
55847 | CISD1 | CRC-1-8810 | Human | Colorectum | CRC | 1.21e-03 | -2.02e-01 | 0.6257 |
55847 | CISD1 | CRC-3-11773 | Human | Colorectum | CRC | 3.43e-07 | -2.34e-01 | 0.2564 |
55847 | CISD1 | LZE4T | Human | Esophagus | ESCC | 1.24e-15 | 4.23e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434577 | Oral cavity | OSCC | regulation of cellular respiration | 31/7305 | 49/18723 | 5.04e-04 | 2.95e-03 | 31 |
GO:004533319 | Oral cavity | LP | cellular respiration | 124/4623 | 230/18723 | 1.35e-21 | 3.38e-19 | 124 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
GO:001598019 | Oral cavity | LP | energy derivation by oxidation of organic compounds | 145/4623 | 318/18723 | 2.44e-16 | 3.64e-14 | 145 |
GO:001050615 | Oral cavity | LP | regulation of autophagy | 132/4623 | 317/18723 | 1.82e-11 | 1.28e-09 | 132 |
GO:004345714 | Oral cavity | LP | regulation of cellular respiration | 24/4623 | 49/18723 | 2.00e-04 | 2.18e-03 | 24 |
GO:004346717 | Oral cavity | LP | regulation of generation of precursor metabolites and energy | 50/4623 | 130/18723 | 3.37e-04 | 3.37e-03 | 50 |
GO:0045333111 | Skin | cSCC | cellular respiration | 131/4864 | 230/18723 | 1.57e-23 | 3.39e-21 | 131 |
GO:0006091111 | Skin | cSCC | generation of precursor metabolites and energy | 224/4864 | 490/18723 | 1.13e-21 | 2.21e-19 | 224 |
GO:001598026 | Skin | cSCC | energy derivation by oxidation of organic compounds | 154/4864 | 318/18723 | 4.19e-18 | 5.15e-16 | 154 |
GO:001050619 | Skin | cSCC | regulation of autophagy | 127/4864 | 317/18723 | 2.36e-08 | 6.71e-07 | 127 |
GO:00434578 | Skin | cSCC | regulation of cellular respiration | 24/4864 | 49/18723 | 4.54e-04 | 3.47e-03 | 24 |
GO:004346720 | Skin | cSCC | regulation of generation of precursor metabolites and energy | 51/4864 | 130/18723 | 6.18e-04 | 4.46e-03 | 51 |
GO:0006091112 | Thyroid | PTC | generation of precursor metabolites and energy | 252/5968 | 490/18723 | 8.24e-20 | 1.13e-17 | 252 |
GO:0045333112 | Thyroid | PTC | cellular respiration | 140/5968 | 230/18723 | 9.60e-20 | 1.26e-17 | 140 |
GO:0015980111 | Thyroid | PTC | energy derivation by oxidation of organic compounds | 176/5968 | 318/18723 | 2.67e-18 | 2.90e-16 | 176 |
GO:0010506110 | Thyroid | PTC | regulation of autophagy | 172/5968 | 317/18723 | 8.76e-17 | 7.57e-15 | 172 |
GO:0043467110 | Thyroid | PTC | regulation of generation of precursor metabolites and energy | 68/5968 | 130/18723 | 1.03e-06 | 1.52e-05 | 68 |
GO:004345715 | Thyroid | PTC | regulation of cellular respiration | 28/5968 | 49/18723 | 2.25e-04 | 1.64e-03 | 28 |
GO:000609134 | Thyroid | ATC | generation of precursor metabolites and energy | 256/6293 | 490/18723 | 6.55e-18 | 7.69e-16 | 256 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CISD1 | SNV | Missense_Mutation | c.217N>T | p.Arg73Cys | p.R73C | Q9NZ45 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | |
CISD1 | SNV | Missense_Mutation | rs769192686 | c.206N>T | p.Ala69Val | p.A69V | Q9NZ45 | protein_coding | tolerated(0.07) | possibly_damaging(0.859) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CISD1 | SNV | Missense_Mutation | novel | c.62C>T | p.Ala21Val | p.A21V | Q9NZ45 | protein_coding | tolerated(0.14) | benign(0.103) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CISD1 | SNV | Missense_Mutation | c.313A>G | p.Lys105Glu | p.K105E | Q9NZ45 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CISD1 | SNV | Missense_Mutation | novel | c.241N>A | p.Pro81Thr | p.P81T | Q9NZ45 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CISD1 | SNV | Missense_Mutation | c.251A>G | p.Asp84Gly | p.D84G | Q9NZ45 | protein_coding | deleterious(0.02) | probably_damaging(0.94) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CISD1 | SNV | Missense_Mutation | novel | c.205G>T | p.Ala69Ser | p.A69S | Q9NZ45 | protein_coding | deleterious(0.04) | possibly_damaging(0.814) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CISD1 | SNV | Missense_Mutation | c.218G>T | p.Arg73Leu | p.R73L | Q9NZ45 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CISD1 | SNV | Missense_Mutation | c.103N>C | p.Tyr35His | p.Y35H | Q9NZ45 | protein_coding | tolerated(0.2) | possibly_damaging(0.827) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CISD1 | SNV | Missense_Mutation | rs568388348 | c.226N>G | p.Arg76Gly | p.R76G | Q9NZ45 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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