Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CHP2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CHP2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CHP2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
GO:00468221 | Colorectum | SER | regulation of nucleocytoplasmic transport | 34/2897 | 106/18723 | 1.46e-05 | 4.47e-04 | 34 |
GO:00468241 | Colorectum | SER | positive regulation of nucleocytoplasmic transport | 23/2897 | 62/18723 | 2.64e-05 | 7.21e-04 | 23 |
GO:00100381 | Colorectum | SER | response to metal ion | 84/2897 | 373/18723 | 1.87e-04 | 3.44e-03 | 84 |
GO:19045891 | Colorectum | SER | regulation of protein import | 21/2897 | 63/18723 | 3.35e-04 | 5.30e-03 | 21 |
GO:19045911 | Colorectum | SER | positive regulation of protein import | 16/2897 | 43/18723 | 4.18e-04 | 6.17e-03 | 16 |
GO:00423071 | Colorectum | SER | positive regulation of protein import into nucleus | 15/2897 | 41/18723 | 7.73e-04 | 9.84e-03 | 15 |
GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
GO:00423061 | Colorectum | SER | regulation of protein import into nucleus | 19/2897 | 60/18723 | 1.28e-03 | 1.43e-02 | 19 |
GO:00109211 | Colorectum | SER | regulation of phosphatase activity | 24/2897 | 84/18723 | 1.61e-03 | 1.71e-02 | 24 |
GO:00353031 | Colorectum | SER | regulation of dephosphorylation | 33/2897 | 128/18723 | 1.71e-03 | 1.78e-02 | 33 |
GO:00712411 | Colorectum | SER | cellular response to inorganic substance | 52/2897 | 226/18723 | 1.77e-03 | 1.82e-02 | 52 |
GO:00712481 | Colorectum | SER | cellular response to metal ion | 46/2897 | 197/18723 | 2.31e-03 | 2.21e-02 | 46 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:00511701 | Colorectum | SER | import into nucleus | 38/2897 | 159/18723 | 3.48e-03 | 2.95e-02 | 38 |
GO:00066061 | Colorectum | SER | protein import into nucleus | 36/2897 | 155/18723 | 7.07e-03 | 4.98e-02 | 36 |
GO:19038294 | Colorectum | FAP | positive regulation of cellular protein localization | 79/2622 | 276/18723 | 1.59e-10 | 4.38e-08 | 79 |
GO:19049514 | Colorectum | FAP | positive regulation of establishment of protein localization | 82/2622 | 319/18723 | 1.83e-08 | 1.87e-06 | 82 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHP2 | SNV | Missense_Mutation | rs138042112 | c.523N>A | p.Val175Met | p.V175M | O43745 | protein_coding | tolerated(0.08) | benign(0) | TCGA-A1-A0SG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
CHP2 | SNV | Missense_Mutation | novel | c.326N>C | p.Leu109Pro | p.L109P | O43745 | protein_coding | deleterious(0.04) | benign(0.071) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
CHP2 | SNV | Missense_Mutation | novel | c.462G>T | p.Glu154Asp | p.E154D | O43745 | protein_coding | tolerated(0.45) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | rs773423633 | c.475N>T | p.Arg159Cys | p.R159C | O43745 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | | c.479N>T | p.Thr160Met | p.T160M | O43745 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CHP2 | SNV | Missense_Mutation | novel | c.289G>T | p.Asp97Tyr | p.D97Y | O43745 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | rs756892483 | c.512N>T | p.Ala171Val | p.A171V | O43745 | protein_coding | tolerated(0.28) | benign(0.027) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | novel | c.344A>C | p.Lys115Thr | p.K115T | O43745 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CHP2 | SNV | Missense_Mutation | rs368850634 | c.289N>A | p.Asp97Asn | p.D97N | O43745 | protein_coding | tolerated(0.32) | benign(0.013) | TCGA-AX-A06D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
CHP2 | SNV | Missense_Mutation | rs751008002 | c.578N>A | p.Arg193Gln | p.R193Q | O43745 | protein_coding | deleterious(0.02) | benign(0.34) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |