GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051298 | Thyroid | PTC | centrosome duplication | 36/5968 | 73/18723 | 1.41e-03 | 7.89e-03 | 36 |
GO:00108244 | Thyroid | PTC | regulation of centrosome duplication | 24/5968 | 45/18723 | 2.28e-03 | 1.20e-02 | 24 |
GO:00309536 | Thyroid | PTC | astral microtubule organization | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:00466055 | Thyroid | PTC | regulation of centrosome cycle | 25/5968 | 49/18723 | 4.09e-03 | 1.95e-02 | 25 |
GO:00070207 | Thyroid | PTC | microtubule nucleation | 18/5968 | 35/18723 | 1.26e-02 | 4.90e-02 | 18 |
GO:190495128 | Thyroid | ATC | positive regulation of establishment of protein localization | 177/6293 | 319/18723 | 5.43e-16 | 4.29e-14 | 177 |
GO:000705122 | Thyroid | ATC | spindle organization | 109/6293 | 184/18723 | 7.99e-13 | 3.46e-11 | 109 |
GO:005125829 | Thyroid | ATC | protein polymerization | 159/6293 | 297/18723 | 9.33e-13 | 3.96e-11 | 159 |
GO:0051495111 | Thyroid | ATC | positive regulation of cytoskeleton organization | 125/6293 | 226/18723 | 1.39e-11 | 5.08e-10 | 125 |
GO:004578719 | Thyroid | ATC | positive regulation of cell cycle | 158/6293 | 313/18723 | 4.18e-10 | 1.14e-08 | 158 |
GO:009006817 | Thyroid | ATC | positive regulation of cell cycle process | 115/6293 | 236/18723 | 9.87e-07 | 1.29e-05 | 115 |
GO:003288613 | Thyroid | ATC | regulation of microtubule-based process | 114/6293 | 240/18723 | 5.17e-06 | 5.59e-05 | 114 |
GO:190211522 | Thyroid | ATC | regulation of organelle assembly | 90/6293 | 186/18723 | 2.00e-05 | 1.81e-04 | 90 |
GO:003112215 | Thyroid | ATC | cytoplasmic microtubule organization | 34/6293 | 56/18723 | 2.92e-05 | 2.45e-04 | 34 |
GO:003102311 | Thyroid | ATC | microtubule organizing center organization | 71/6293 | 143/18723 | 5.11e-05 | 3.99e-04 | 71 |
GO:000709811 | Thyroid | ATC | centrosome cycle | 65/6293 | 130/18723 | 7.95e-05 | 5.97e-04 | 65 |
GO:004678514 | Thyroid | ATC | microtubule polymerization | 45/6293 | 83/18723 | 8.75e-05 | 6.51e-04 | 45 |
GO:003110912 | Thyroid | ATC | microtubule polymerization or depolymerization | 61/6293 | 122/18723 | 1.30e-04 | 9.15e-04 | 61 |
GO:190211713 | Thyroid | ATC | positive regulation of organelle assembly | 36/6293 | 67/18723 | 5.41e-04 | 3.13e-03 | 36 |
GO:003095312 | Thyroid | ATC | astral microtubule organization | 8/6293 | 10/18723 | 3.60e-03 | 1.58e-02 | 8 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPJ | SNV | Missense_Mutation | novel | c.2437N>A | p.Leu813Ile | p.L813I | Q9HC77 | protein_coding | tolerated(0.09) | benign(0.014) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
CENPJ | SNV | Missense_Mutation | | c.429N>A | p.Phe143Leu | p.F143L | Q9HC77 | protein_coding | tolerated(0.83) | benign(0.048) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
CENPJ | SNV | Missense_Mutation | novel | c.3314N>A | p.Arg1105Gln | p.R1105Q | Q9HC77 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CENPJ | SNV | Missense_Mutation | | c.1225N>A | p.Asp409Asn | p.D409N | Q9HC77 | protein_coding | deleterious(0.02) | benign(0.386) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CENPJ | SNV | Missense_Mutation | novel | c.2932G>A | p.Glu978Lys | p.E978K | Q9HC77 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-LD-A7W5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
CENPJ | SNV | Missense_Mutation | rs142535552 | c.1409N>T | p.Pro470Leu | p.P470L | Q9HC77 | protein_coding | deleterious(0) | benign(0.005) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CENPJ | insertion | Frame_Shift_Ins | novel | c.1206_1207insGTTCTAACGCATGTACACACCTACCTCATTCCATTTA | p.Asn403ValfsTer24 | p.N403Vfs*24 | Q9HC77 | protein_coding | | | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
CENPJ | insertion | Frame_Shift_Ins | novel | c.1961_1962insTGCTGATACATACTGTAAATGTATGCTTATCATAGTAGTTATGGGTAAA | p.Pro655AlafsTer27 | p.P655Afs*27 | Q9HC77 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
CENPJ | insertion | In_Frame_Ins | novel | c.149_150insCAGTCCTTATTGGTGTTCCTGGCATGTAGTGAG | p.Ser51_Thr52insProTyrTrpCysSerTrpHisValValSerSer | p.S51_T52insPYWCSWHVVSS | Q9HC77 | protein_coding | | | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CENPJ | SNV | Missense_Mutation | novel | c.924G>T | p.Lys308Asn | p.K308N | Q9HC77 | protein_coding | tolerated(0.51) | benign(0.015) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |