Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CAPRIN1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CAPRIN1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAPRIN1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAPRIN1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAPRIN1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAPRIN1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CAPRIN1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAPRIN1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00610011 | Colorectum | FAP | regulation of dendritic spine morphogenesis | 14/2622 | 47/18723 | 3.95e-03 | 2.75e-02 | 14 |
GO:00342491 | Colorectum | FAP | negative regulation of cellular amide metabolic process | 54/2622 | 273/18723 | 5.00e-03 | 3.33e-02 | 54 |
GO:0060998 | Colorectum | FAP | regulation of dendritic spine development | 16/2622 | 61/18723 | 8.38e-03 | 4.89e-02 | 16 |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:01060274 | Colorectum | CRC | neuron projection organization | 28/2078 | 93/18723 | 5.17e-07 | 3.73e-05 | 28 |
GO:00109754 | Colorectum | CRC | regulation of neuron projection development | 82/2078 | 445/18723 | 2.51e-06 | 1.19e-04 | 82 |
GO:00107204 | Colorectum | CRC | positive regulation of cell development | 60/2078 | 298/18723 | 3.27e-06 | 1.47e-04 | 60 |
GO:00313464 | Colorectum | CRC | positive regulation of cell projection organization | 67/2078 | 353/18723 | 7.45e-06 | 2.72e-04 | 67 |
GO:00970614 | Colorectum | CRC | dendritic spine organization | 24/2078 | 84/18723 | 9.01e-06 | 3.15e-04 | 24 |
GO:00507673 | Colorectum | CRC | regulation of neurogenesis | 68/2078 | 364/18723 | 1.11e-05 | 3.62e-04 | 68 |
GO:00163584 | Colorectum | CRC | dendrite development | 50/2078 | 243/18723 | 1.13e-05 | 3.67e-04 | 50 |
GO:00064175 | Colorectum | CRC | regulation of translation | 82/2078 | 468/18723 | 1.79e-05 | 5.40e-04 | 82 |
GO:00991734 | Colorectum | CRC | postsynapse organization | 36/2078 | 168/18723 | 7.61e-05 | 1.59e-03 | 36 |
GO:00107695 | Colorectum | CRC | regulation of cell morphogenesis involved in differentiation | 24/2078 | 96/18723 | 9.80e-05 | 1.96e-03 | 24 |
GO:00488132 | Colorectum | CRC | dendrite morphogenesis | 32/2078 | 146/18723 | 1.19e-04 | 2.33e-03 | 32 |
GO:00507692 | Colorectum | CRC | positive regulation of neurogenesis | 43/2078 | 225/18723 | 2.58e-04 | 4.19e-03 | 43 |
GO:00508084 | Colorectum | CRC | synapse organization | 71/2078 | 426/18723 | 3.02e-04 | 4.76e-03 | 71 |
GO:00107705 | Colorectum | CRC | positive regulation of cell morphogenesis involved in differentiation | 20/2078 | 79/18723 | 3.03e-04 | 4.77e-03 | 20 |
GO:00609972 | Colorectum | CRC | dendritic spine morphogenesis | 16/2078 | 61/18723 | 7.76e-04 | 9.87e-03 | 16 |
GO:00519602 | Colorectum | CRC | regulation of nervous system development | 71/2078 | 443/18723 | 9.28e-04 | 1.14e-02 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPRIN1 | SNV | Missense_Mutation | rs772325651 | c.1624C>G | p.Gln542Glu | p.Q542E | Q14444 | protein_coding | tolerated(0.23) | possibly_damaging(0.814) | TCGA-AO-A12H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.233A>G | p.Tyr78Cys | p.Y78C | Q14444 | protein_coding | deleterious(0.01) | benign(0.014) | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.253N>A | p.Gly85Arg | p.G85R | Q14444 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1141N>A | p.Glu381Lys | p.E381K | Q14444 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CAPRIN1 | SNV | Missense_Mutation | rs148571717 | c.1744N>G | p.Gln582Glu | p.Q582E | Q14444 | protein_coding | tolerated(0.44) | possibly_damaging(0.498) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
CAPRIN1 | SNV | Missense_Mutation | novel | c.395N>T | p.Arg132Leu | p.R132L | Q14444 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CAPRIN1 | SNV | Missense_Mutation | | c.370C>G | p.Gln124Glu | p.Q124E | Q14444 | protein_coding | tolerated(0.14) | probably_damaging(0.98) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CAPRIN1 | SNV | Missense_Mutation | | c.418N>C | p.Glu140Gln | p.E140Q | Q14444 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAPRIN1 | SNV | Missense_Mutation | | c.2054N>A | p.Gly685Glu | p.G685E | Q14444 | protein_coding | deleterious(0) | possibly_damaging(0.617) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAPRIN1 | SNV | Missense_Mutation | novel | c.1244C>G | p.Ser415Cys | p.S415C | Q14444 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-VS-A8Q8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |