Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAND1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAND1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAND1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAND1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CAND1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAND1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200014211 | Oral cavity | LP | regulation of DNA-templated transcription, initiation | 18/4623 | 40/18723 | 4.00e-03 | 2.59e-02 | 18 |
GO:00063521 | Oral cavity | LP | DNA-templated transcription, initiation | 45/4623 | 130/18723 | 7.03e-03 | 3.96e-02 | 45 |
GO:006026011 | Oral cavity | LP | regulation of transcription initiation from RNA polymerase II promoter | 15/4623 | 33/18723 | 7.43e-03 | 4.13e-02 | 15 |
GO:004325418 | Prostate | BPH | regulation of protein-containing complex assembly | 133/3107 | 428/18723 | 5.40e-14 | 6.08e-12 | 133 |
GO:003133418 | Prostate | BPH | positive regulation of protein-containing complex assembly | 84/3107 | 237/18723 | 1.24e-12 | 1.04e-10 | 84 |
GO:004325419 | Prostate | Tumor | regulation of protein-containing complex assembly | 132/3246 | 428/18723 | 3.32e-12 | 2.78e-10 | 132 |
GO:003133419 | Prostate | Tumor | positive regulation of protein-containing complex assembly | 80/3246 | 237/18723 | 6.10e-10 | 3.11e-08 | 80 |
GO:004325429 | Skin | cSCC | regulation of protein-containing complex assembly | 167/4864 | 428/18723 | 1.60e-09 | 5.97e-08 | 167 |
GO:0031334112 | Skin | cSCC | positive regulation of protein-containing complex assembly | 97/4864 | 237/18723 | 3.22e-07 | 6.51e-06 | 97 |
GO:000635212 | Skin | cSCC | DNA-templated transcription, initiation | 57/4864 | 130/18723 | 7.28e-06 | 1.01e-04 | 57 |
GO:00063674 | Skin | cSCC | transcription initiation from RNA polymerase II promoter | 37/4864 | 77/18723 | 2.53e-05 | 2.87e-04 | 37 |
GO:00708974 | Skin | cSCC | transcription preinitiation complex assembly | 21/4864 | 36/18723 | 3.98e-05 | 4.26e-04 | 21 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:00511233 | Skin | cSCC | RNA polymerase II preinitiation complex assembly | 14/4864 | 24/18723 | 7.90e-04 | 5.47e-03 | 14 |
GO:20001425 | Skin | cSCC | regulation of DNA-templated transcription, initiation | 18/4864 | 40/18723 | 7.10e-03 | 3.40e-02 | 18 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0031334113 | Thyroid | PTC | positive regulation of protein-containing complex assembly | 121/5968 | 237/18723 | 5.70e-10 | 1.81e-08 | 121 |
GO:00063675 | Thyroid | PTC | transcription initiation from RNA polymerase II promoter | 44/5968 | 77/18723 | 4.04e-06 | 5.05e-05 | 44 |
GO:00063525 | Thyroid | PTC | DNA-templated transcription, initiation | 63/5968 | 130/18723 | 5.72e-05 | 5.05e-04 | 63 |
GO:00708975 | Thyroid | PTC | transcription preinitiation complex assembly | 22/5968 | 36/18723 | 2.85e-04 | 2.02e-03 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAND1 | SNV | Missense_Mutation | | c.486N>C | p.Leu162Phe | p.L162F | Q86VP6 | protein_coding | deleterious(0.01) | benign(0.384) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAND1 | SNV | Missense_Mutation | novel | c.3425N>C | p.Leu1142Ser | p.L1142S | Q86VP6 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAND1 | SNV | Missense_Mutation | rs199801743 | c.3152A>G | p.His1051Arg | p.H1051R | Q86VP6 | protein_coding | tolerated(0.42) | benign(0.007) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CAND1 | SNV | Missense_Mutation | | c.520N>T | p.Pro174Ser | p.P174S | Q86VP6 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAND1 | SNV | Missense_Mutation | rs773906312 | c.1673C>T | p.Ser558Leu | p.S558L | Q86VP6 | protein_coding | tolerated(0.31) | benign(0) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CAND1 | SNV | Missense_Mutation | | c.292N>A | p.Asp98Asn | p.D98N | Q86VP6 | protein_coding | tolerated(0.2) | benign(0.055) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CAND1 | SNV | Missense_Mutation | | c.541N>T | p.Leu181Phe | p.L181F | Q86VP6 | protein_coding | deleterious(0.03) | possibly_damaging(0.839) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAND1 | insertion | Frame_Shift_Ins | novel | c.2485_2486insACCAGAGAGCTTTGAAACTGGGTACTCTTTCTGCCCTT | p.Arg829AsnfsTer22 | p.R829Nfs*22 | Q86VP6 | protein_coding | | | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
CAND1 | insertion | Nonsense_Mutation | novel | c.3349_3350insA | p.Tyr1117Ter | p.Y1117* | Q86VP6 | protein_coding | | | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
CAND1 | insertion | Frame_Shift_Ins | novel | c.3154_3155insAACTGGTG | p.Leu1052GlnfsTer15 | p.L1052Qfs*15 | Q86VP6 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |