Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/C20orf27_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/C20orf27_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/C20orf27_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/C20orf27_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/C20orf27_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/C20orf27_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19038446 | Oral cavity | OSCC | regulation of cellular response to transforming growth factor beta stimulus | 72/7305 | 131/18723 | 1.51e-04 | 1.06e-03 | 72 |
GO:00305114 | Oral cavity | OSCC | positive regulation of transforming growth factor beta receptor signaling pathway | 23/7305 | 32/18723 | 1.67e-04 | 1.14e-03 | 23 |
GO:19038464 | Oral cavity | OSCC | positive regulation of cellular response to transforming growth factor beta stimulus | 23/7305 | 32/18723 | 1.67e-04 | 1.14e-03 | 23 |
GO:19012246 | Oral cavity | OSCC | positive regulation of NIK/NF-kappaB signaling | 40/7305 | 69/18723 | 1.08e-03 | 5.56e-03 | 40 |
GO:19012224 | Oral cavity | OSCC | regulation of NIK/NF-kappaB signaling | 59/7305 | 112/18723 | 2.25e-03 | 1.00e-02 | 59 |
GO:00071789 | Oral cavity | OSCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 165/7305 | 355/18723 | 2.31e-03 | 1.02e-02 | 165 |
GO:190122212 | Oral cavity | LP | regulation of NIK/NF-kappaB signaling | 44/4623 | 112/18723 | 4.38e-04 | 4.19e-03 | 44 |
GO:190122413 | Oral cavity | LP | positive regulation of NIK/NF-kappaB signaling | 29/4623 | 69/18723 | 1.15e-03 | 9.40e-03 | 29 |
GO:003806112 | Oral cavity | LP | NIK/NF-kappaB signaling | 52/4623 | 143/18723 | 1.20e-03 | 9.66e-03 | 52 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:007156025 | Skin | cSCC | cellular response to transforming growth factor beta stimulus | 92/4864 | 250/18723 | 9.65e-05 | 8.99e-04 | 92 |
GO:19012248 | Skin | cSCC | positive regulation of NIK/NF-kappaB signaling | 30/4864 | 69/18723 | 1.19e-03 | 7.75e-03 | 30 |
GO:000717917 | Skin | cSCC | transforming growth factor beta receptor signaling pathway | 69/4864 | 198/18723 | 3.39e-03 | 1.84e-02 | 69 |
GO:00380616 | Skin | cSCC | NIK/NF-kappaB signaling | 52/4864 | 143/18723 | 3.83e-03 | 2.05e-02 | 52 |
GO:19012225 | Skin | cSCC | regulation of NIK/NF-kappaB signaling | 42/4864 | 112/18723 | 4.71e-03 | 2.40e-02 | 42 |
GO:007155919 | Thyroid | PTC | response to transforming growth factor beta | 131/5968 | 256/18723 | 9.20e-11 | 3.17e-09 | 131 |
GO:007156019 | Thyroid | PTC | cellular response to transforming growth factor beta stimulus | 126/5968 | 250/18723 | 7.34e-10 | 2.19e-08 | 126 |
GO:000717919 | Thyroid | PTC | transforming growth factor beta receptor signaling pathway | 104/5968 | 198/18723 | 1.20e-09 | 3.47e-08 | 104 |
GO:001701515 | Thyroid | PTC | regulation of transforming growth factor beta receptor signaling pathway | 69/5968 | 128/18723 | 1.92e-07 | 3.51e-06 | 69 |
GO:190384415 | Thyroid | PTC | regulation of cellular response to transforming growth factor beta stimulus | 70/5968 | 131/18723 | 2.47e-07 | 4.31e-06 | 70 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C20orf27 | insertion | Nonsense_Mutation | novel | c.165_166insACCTGAGTTTCTTTTCTCTCAAGTGGAGACAAT | p.Val55_His56insThrTerValSerPheLeuSerSerGlyAspAsn | p.V55_H56insT*VSFLSSGDN | Q9GZN8 | protein_coding | | | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
C20orf27 | deletion | Frame_Shift_Del | novel | c.78delN | p.Arg27GlyfsTer57 | p.R27Gfs*57 | Q9GZN8 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
C20orf27 | SNV | Missense_Mutation | | c.283N>G | p.Leu95Val | p.L95V | Q9GZN8 | protein_coding | tolerated(0.15) | benign(0.391) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | rs746348018 | c.155A>C | p.His52Pro | p.H52P | Q9GZN8 | protein_coding | tolerated(0.38) | benign(0) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | novel | c.212N>G | p.Glu71Gly | p.E71G | Q9GZN8 | protein_coding | deleterious(0.02) | possibly_damaging(0.744) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | novel | c.374N>C | p.Glu125Ala | p.E125A | Q9GZN8 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | rs746711207 | c.491N>A | p.Arg164His | p.R164H | Q9GZN8 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | rs752711158 | c.122N>A | p.Arg41His | p.R41H | Q9GZN8 | protein_coding | tolerated(0.06) | possibly_damaging(0.528) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | novel | c.514N>G | p.Thr172Ala | p.T172A | Q9GZN8 | protein_coding | deleterious(0) | possibly_damaging(0.719) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
C20orf27 | SNV | Missense_Mutation | novel | c.542N>A | p.Cys181Tyr | p.C181Y | Q9GZN8 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |