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Gene: BMPR1A |
Gene summary for BMPR1A |
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Gene information | Species | Human | Gene symbol | BMPR1A | Gene ID | 657 |
Gene name | bone morphogenetic protein receptor type 1A | |
Gene Alias | 10q23del | |
Cytomap | 10q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P36894 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
657 | BMPR1A | CCI_1 | Human | Cervix | CC | 1.95e-04 | 5.46e-01 | 0.528 |
657 | BMPR1A | CCI_2 | Human | Cervix | CC | 6.52e-04 | 7.77e-01 | 0.5249 |
657 | BMPR1A | CCI_3 | Human | Cervix | CC | 3.18e-02 | 3.94e-01 | 0.516 |
657 | BMPR1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.50e-07 | -4.03e-01 | 0.0155 |
657 | BMPR1A | HTA11_83_2000001011 | Human | Colorectum | SER | 9.73e-04 | -2.39e-01 | -0.1526 |
657 | BMPR1A | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.67e-02 | -5.75e-01 | -0.2061 |
657 | BMPR1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.08e-04 | -2.85e-01 | 0.0674 |
657 | BMPR1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.33e-09 | -4.33e-01 | 0.3005 |
657 | BMPR1A | A001-C-207 | Human | Colorectum | FAP | 3.52e-02 | -3.04e-01 | 0.1278 |
657 | BMPR1A | A015-C-203 | Human | Colorectum | FAP | 1.52e-31 | -5.15e-01 | -0.1294 |
657 | BMPR1A | A015-C-204 | Human | Colorectum | FAP | 1.45e-05 | -2.90e-01 | -0.0228 |
657 | BMPR1A | A014-C-040 | Human | Colorectum | FAP | 3.34e-02 | -1.10e-01 | -0.1184 |
657 | BMPR1A | A002-C-201 | Human | Colorectum | FAP | 2.11e-13 | -4.52e-01 | 0.0324 |
657 | BMPR1A | A002-C-203 | Human | Colorectum | FAP | 1.67e-02 | -1.33e-01 | 0.2786 |
657 | BMPR1A | A001-C-119 | Human | Colorectum | FAP | 3.18e-11 | -5.76e-01 | -0.1557 |
657 | BMPR1A | A001-C-108 | Human | Colorectum | FAP | 3.66e-21 | -3.77e-01 | -0.0272 |
657 | BMPR1A | A002-C-205 | Human | Colorectum | FAP | 1.69e-18 | -4.09e-01 | -0.1236 |
657 | BMPR1A | A001-C-104 | Human | Colorectum | FAP | 4.87e-04 | -2.73e-01 | 0.0184 |
657 | BMPR1A | A015-C-006 | Human | Colorectum | FAP | 1.47e-13 | -5.33e-01 | -0.0994 |
657 | BMPR1A | A015-C-106 | Human | Colorectum | FAP | 3.87e-14 | -3.58e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001704 | Cervix | CC | formation of primary germ layer | 27/2311 | 121/18723 | 1.49e-03 | 1.16e-02 | 27 |
GO:00303245 | Cervix | CC | lung development | 36/2311 | 177/18723 | 1.64e-03 | 1.26e-02 | 36 |
GO:00015037 | Cervix | CC | ossification | 71/2311 | 408/18723 | 1.67e-03 | 1.28e-02 | 71 |
GO:00487365 | Cervix | CC | appendage development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00601735 | Cervix | CC | limb development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00303235 | Cervix | CC | respiratory tube development | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00605413 | Cervix | CC | respiratory system development | 39/2311 | 203/18723 | 3.18e-03 | 2.07e-02 | 39 |
GO:00486593 | Cervix | CC | smooth muscle cell proliferation | 36/2311 | 184/18723 | 3.27e-03 | 2.13e-02 | 36 |
GO:00071795 | Cervix | CC | transforming growth factor beta receptor signaling pathway | 38/2311 | 198/18723 | 3.62e-03 | 2.31e-02 | 38 |
GO:00486603 | Cervix | CC | regulation of smooth muscle cell proliferation | 35/2311 | 180/18723 | 4.10e-03 | 2.54e-02 | 35 |
GO:0014855 | Cervix | CC | striated muscle cell proliferation | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:00302781 | Cervix | CC | regulation of ossification | 24/2311 | 115/18723 | 6.51e-03 | 3.61e-02 | 24 |
GO:0030501 | Cervix | CC | positive regulation of bone mineralization | 11/2311 | 40/18723 | 7.54e-03 | 4.02e-02 | 11 |
GO:00486612 | Cervix | CC | positive regulation of smooth muscle cell proliferation | 22/2311 | 104/18723 | 7.59e-03 | 4.04e-02 | 22 |
GO:00486395 | Cervix | CC | positive regulation of developmental growth | 33/2311 | 174/18723 | 7.65e-03 | 4.07e-02 | 33 |
GO:0031214 | Cervix | CC | biomineral tissue development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:0045669 | Cervix | CC | positive regulation of osteoblast differentiation | 16/2311 | 69/18723 | 8.75e-03 | 4.48e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05418110 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054182 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa054183 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa054184 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa054185 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa054189 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa0541810 | Colorectum | CRC | Fluid shear stress and atherosclerosis | 32/1091 | 139/8465 | 6.52e-04 | 5.89e-03 | 3.99e-03 | 32 |
hsa043904 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Cervix | CC |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP4 | BMPR1A_BMPR2 | BMP4_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP6 | BMPR1A_BMPR2 | BMP6_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP4 | BMPR1A_ACVR2A | BMP4_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP4 | BMPR1A_BMPR2 | BMP4_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP6 | BMPR1A_ACVR2A | BMP6_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP6 | BMPR1A_BMPR2 | BMP6_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | CRC |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP6 | BMPR1A_ACVR2A | BMP6_BMPR1A_ACVR2A | BMP | CRC | FAP |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779N>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A2-A25F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
BMPR1A | SNV | Missense_Mutation | novel | c.11N>A | p.Leu4Gln | p.L4Q | P36894 | protein_coding | deleterious_low_confidence(0.02) | benign(0.135) | TCGA-A7-A426-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779T>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BMPR1A | SNV | Missense_Mutation | rs755740570 | c.779N>G | p.Val260Gly | p.V260G | P36894 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
BMPR1A | SNV | Missense_Mutation | rs786202611 | c.1231G>A | p.Glu411Lys | p.E411K | P36894 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMPR1A | SNV | Missense_Mutation | c.856G>A | p.Glu286Lys | p.E286K | P36894 | protein_coding | tolerated(0.09) | benign(0.246) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BMPR1A | SNV | Missense_Mutation | c.734N>G | p.Tyr245Cys | p.Y245C | P36894 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BMPR1A | SNV | Missense_Mutation | rs758309022 | c.1379N>C | p.Met460Thr | p.M460T | P36894 | protein_coding | tolerated(0.07) | possibly_damaging(0.491) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMPR1A | SNV | Missense_Mutation | c.1561C>T | p.Leu521Phe | p.L521F | P36894 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
BMPR1A | SNV | Missense_Mutation | novel | c.55N>G | p.Ser19Ala | p.S19A | P36894 | protein_coding | tolerated_low_confidence(0.5) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565824 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 252166689 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565800 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565835 | ||
657 | BMPR1A | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 249565801 |
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