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Gene: BASP1 |
Gene summary for BASP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | BASP1 | Gene ID | 10409 |
Gene name | brain abundant membrane attached signal protein 1 | |
Gene Alias | CAP-23 | |
Cytomap | 5p15.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P80723 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10409 | BASP1 | GSM4909281 | Human | Breast | IDC | 2.18e-11 | 3.13e-01 | 0.21 |
10409 | BASP1 | GSM4909285 | Human | Breast | IDC | 5.23e-25 | 5.22e-01 | 0.21 |
10409 | BASP1 | GSM4909286 | Human | Breast | IDC | 2.18e-23 | 4.24e-01 | 0.1081 |
10409 | BASP1 | GSM4909307 | Human | Breast | IDC | 1.69e-14 | 4.29e-01 | 0.1569 |
10409 | BASP1 | GSM4909308 | Human | Breast | IDC | 4.50e-57 | 9.22e-01 | 0.158 |
10409 | BASP1 | M5 | Human | Breast | IDC | 4.50e-02 | 5.14e-01 | 0.1598 |
10409 | BASP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.80e-03 | 6.62e-01 | 0.0131 |
10409 | BASP1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.10e-05 | 5.20e-01 | -0.0177 |
10409 | BASP1 | AEH-subject2 | Human | Endometrium | AEH | 1.11e-02 | -1.31e-01 | -0.2525 |
10409 | BASP1 | AEH-subject4 | Human | Endometrium | AEH | 1.34e-02 | -1.17e-01 | -0.2657 |
10409 | BASP1 | AEH-subject5 | Human | Endometrium | AEH | 1.65e-02 | -2.85e-01 | -0.2953 |
10409 | BASP1 | EEC-subject1 | Human | Endometrium | EEC | 5.20e-04 | -8.52e-02 | -0.2682 |
10409 | BASP1 | EEC-subject2 | Human | Endometrium | EEC | 5.72e-19 | -4.93e-01 | -0.2607 |
10409 | BASP1 | EEC-subject3 | Human | Endometrium | EEC | 2.73e-22 | -2.17e-01 | -0.2525 |
10409 | BASP1 | EEC-subject4 | Human | Endometrium | EEC | 2.39e-11 | -4.03e-01 | -0.2571 |
10409 | BASP1 | EEC-subject5 | Human | Endometrium | EEC | 1.58e-17 | -4.94e-01 | -0.249 |
10409 | BASP1 | GSM5276934 | Human | Endometrium | EEC | 4.73e-02 | -8.56e-02 | -0.0913 |
10409 | BASP1 | GSM5276935 | Human | Endometrium | EEC | 6.05e-08 | 3.43e-01 | -0.123 |
10409 | BASP1 | GSM5276937 | Human | Endometrium | EEC | 1.28e-04 | -2.61e-01 | -0.0897 |
10409 | BASP1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 9.93e-33 | 7.74e-02 | -0.1869 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00720015 | Endometrium | AEH | renal system development | 61/2100 | 302/18723 | 3.43e-06 | 9.24e-05 | 61 |
GO:002176215 | Endometrium | AEH | substantia nigra development | 16/2100 | 44/18723 | 1.14e-05 | 2.54e-04 | 16 |
GO:00018224 | Endometrium | AEH | kidney development | 57/2100 | 293/18723 | 2.25e-05 | 4.35e-04 | 57 |
GO:00609932 | Endometrium | AEH | kidney morphogenesis | 24/2100 | 93/18723 | 6.73e-05 | 1.04e-03 | 24 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:00016562 | Endometrium | AEH | metanephros development | 22/2100 | 85/18723 | 1.27e-04 | 1.74e-03 | 22 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:004885710 | Endometrium | AEH | neural nucleus development | 18/2100 | 64/18723 | 1.65e-04 | 2.15e-03 | 18 |
GO:003090110 | Endometrium | AEH | midbrain development | 22/2100 | 90/18723 | 3.09e-04 | 3.48e-03 | 22 |
GO:00486387 | Endometrium | AEH | regulation of developmental growth | 58/2100 | 330/18723 | 3.45e-04 | 3.80e-03 | 58 |
GO:00720736 | Endometrium | AEH | kidney epithelium development | 29/2100 | 136/18723 | 4.71e-04 | 4.91e-03 | 29 |
GO:00720093 | Endometrium | AEH | nephron epithelium development | 24/2100 | 109/18723 | 8.69e-04 | 8.03e-03 | 24 |
GO:00720064 | Endometrium | AEH | nephron development | 29/2100 | 142/18723 | 9.80e-04 | 8.89e-03 | 29 |
GO:00610052 | Endometrium | AEH | cell differentiation involved in kidney development | 15/2100 | 57/18723 | 1.20e-03 | 1.04e-02 | 15 |
GO:00358504 | Endometrium | AEH | epithelial cell differentiation involved in kidney development | 13/2100 | 47/18723 | 1.53e-03 | 1.26e-02 | 13 |
GO:00486396 | Endometrium | AEH | positive regulation of developmental growth | 33/2100 | 174/18723 | 1.72e-03 | 1.38e-02 | 33 |
GO:00018232 | Endometrium | AEH | mesonephros development | 21/2100 | 96/18723 | 1.93e-03 | 1.52e-02 | 21 |
GO:00605414 | Endometrium | AEH | respiratory system development | 37/2100 | 203/18723 | 1.97e-03 | 1.54e-02 | 37 |
GO:00016573 | Endometrium | AEH | ureteric bud development | 20/2100 | 91/18723 | 2.31e-03 | 1.74e-02 | 20 |
GO:0035265 | Endometrium | AEH | organ growth | 33/2100 | 178/18723 | 2.53e-03 | 1.87e-02 | 33 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BASP1 | SNV | Missense_Mutation | c.131N>A | p.Ala44Glu | p.A44E | P80723 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-WT-AB44-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
BASP1 | SNV | Missense_Mutation | novel | c.626C>A | p.Pro209His | p.P209H | P80723 | protein_coding | deleterious(0.03) | benign(0.382) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BASP1 | SNV | Missense_Mutation | c.110C>T | p.Pro37Leu | p.P37L | P80723 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | c.380C>T | p.Ala127Val | p.A127V | P80723 | protein_coding | tolerated(0.15) | benign(0.015) | TCGA-CM-6675-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD | |
BASP1 | SNV | Missense_Mutation | c.215N>T | p.Glu72Val | p.E72V | P80723 | protein_coding | tolerated(0.13) | benign(0.026) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | c.86N>T | p.Ala29Val | p.A29V | P80723 | protein_coding | deleterious(0.01) | possibly_damaging(0.494) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | rs767831759 | c.184G>A | p.Ala62Thr | p.A62T | P80723 | protein_coding | tolerated(0.05) | benign(0.013) | TCGA-DC-4745-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
BASP1 | SNV | Missense_Mutation | novel | c.207G>T | p.Lys69Asn | p.K69N | P80723 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BASP1 | SNV | Missense_Mutation | c.11A>C | p.Lys4Thr | p.K4T | P80723 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | novel | c.77N>T | p.Ala26Val | p.A26V | P80723 | protein_coding | tolerated(0.09) | possibly_damaging(0.575) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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