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Gene: BAG2 |
Gene summary for BAG2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BAG2 | Gene ID | 9532 |
| Gene name | BAG cochaperone 2 | |
| Gene Alias | BAG-2 | |
| Cytomap | 6p12.1 | |
| Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | O95816 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9532 | BAG2 | LZE4T | Human | Esophagus | ESCC | 1.78e-05 | 2.28e-01 | 0.0811 |
| 9532 | BAG2 | LZE7T | Human | Esophagus | ESCC | 1.61e-02 | 2.94e-01 | 0.0667 |
| 9532 | BAG2 | LZE22T | Human | Esophagus | ESCC | 8.39e-03 | 5.15e-01 | 0.068 |
| 9532 | BAG2 | LZE24T | Human | Esophagus | ESCC | 2.88e-02 | 1.89e-01 | 0.0596 |
| 9532 | BAG2 | P2T-E | Human | Esophagus | ESCC | 3.37e-08 | 1.69e-01 | 0.1177 |
| 9532 | BAG2 | P4T-E | Human | Esophagus | ESCC | 6.13e-26 | 7.09e-01 | 0.1323 |
| 9532 | BAG2 | P5T-E | Human | Esophagus | ESCC | 1.13e-18 | 4.49e-01 | 0.1327 |
| 9532 | BAG2 | P8T-E | Human | Esophagus | ESCC | 3.20e-02 | 7.57e-02 | 0.0889 |
| 9532 | BAG2 | P9T-E | Human | Esophagus | ESCC | 2.85e-24 | 6.41e-01 | 0.1131 |
| 9532 | BAG2 | P11T-E | Human | Esophagus | ESCC | 5.05e-05 | 3.52e-01 | 0.1426 |
| 9532 | BAG2 | P12T-E | Human | Esophagus | ESCC | 8.85e-04 | 1.17e-01 | 0.1122 |
| 9532 | BAG2 | P15T-E | Human | Esophagus | ESCC | 1.18e-02 | 1.79e-01 | 0.1149 |
| 9532 | BAG2 | P16T-E | Human | Esophagus | ESCC | 1.16e-04 | 1.25e-01 | 0.1153 |
| 9532 | BAG2 | P17T-E | Human | Esophagus | ESCC | 6.63e-07 | 4.05e-01 | 0.1278 |
| 9532 | BAG2 | P19T-E | Human | Esophagus | ESCC | 2.78e-04 | 5.48e-01 | 0.1662 |
| 9532 | BAG2 | P20T-E | Human | Esophagus | ESCC | 5.94e-14 | 2.61e-01 | 0.1124 |
| 9532 | BAG2 | P21T-E | Human | Esophagus | ESCC | 1.56e-33 | 8.29e-01 | 0.1617 |
| 9532 | BAG2 | P22T-E | Human | Esophagus | ESCC | 1.73e-07 | 2.75e-01 | 0.1236 |
| 9532 | BAG2 | P23T-E | Human | Esophagus | ESCC | 7.31e-07 | 2.93e-01 | 0.108 |
| 9532 | BAG2 | P24T-E | Human | Esophagus | ESCC | 5.35e-08 | 2.43e-01 | 0.1287 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
| GO:006113622 | Liver | HCC | regulation of proteasomal protein catabolic process | 134/7958 | 187/18723 | 5.03e-16 | 4.09e-14 | 134 |
| GO:190336422 | Liver | HCC | positive regulation of cellular protein catabolic process | 115/7958 | 155/18723 | 9.30e-16 | 7.19e-14 | 115 |
| GO:004586222 | Liver | HCC | positive regulation of proteolysis | 232/7958 | 372/18723 | 5.66e-15 | 3.98e-13 | 232 |
| GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
| GO:003139622 | Liver | HCC | regulation of protein ubiquitination | 142/7958 | 210/18723 | 1.39e-13 | 7.81e-12 | 142 |
| GO:190305221 | Liver | HCC | positive regulation of proteolysis involved in cellular protein catabolic process | 96/7958 | 133/18723 | 3.47e-12 | 1.57e-10 | 96 |
| GO:190180012 | Liver | HCC | positive regulation of proteasomal protein catabolic process | 84/7958 | 114/18723 | 1.28e-11 | 5.21e-10 | 84 |
| GO:004339322 | Liver | HCC | regulation of protein binding | 129/7958 | 196/18723 | 3.27e-11 | 1.26e-09 | 129 |
| GO:005134822 | Liver | HCC | negative regulation of transferase activity | 166/7958 | 268/18723 | 8.97e-11 | 3.18e-09 | 166 |
| GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
| GO:003139722 | Liver | HCC | negative regulation of protein ubiquitination | 54/7958 | 83/18723 | 2.76e-05 | 2.86e-04 | 54 |
| GO:005110012 | Liver | HCC | negative regulation of binding | 94/7958 | 162/18723 | 4.69e-05 | 4.50e-04 | 94 |
| GO:003209112 | Liver | HCC | negative regulation of protein binding | 59/7958 | 94/18723 | 5.79e-05 | 5.34e-04 | 59 |
| GO:005143821 | Liver | HCC | regulation of ubiquitin-protein transferase activity | 36/7958 | 53/18723 | 1.62e-04 | 1.29e-03 | 36 |
| GO:190332122 | Liver | HCC | negative regulation of protein modification by small protein conjugation or removal | 58/7958 | 95/18723 | 2.01e-04 | 1.56e-03 | 58 |
| GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
| GO:190466622 | Liver | HCC | regulation of ubiquitin protein ligase activity | 18/7958 | 23/18723 | 5.28e-04 | 3.42e-03 | 18 |
| GO:190466722 | Liver | HCC | negative regulation of ubiquitin protein ligase activity | 10/7958 | 12/18723 | 4.79e-03 | 2.02e-02 | 10 |
| GO:19033171 | Liver | HCC | regulation of protein maturation | 39/7958 | 67/18723 | 6.84e-03 | 2.74e-02 | 39 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
| hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
| hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
| hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
| hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
| hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
| hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
| hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BAG2 | SNV | Missense_Mutation | rs759501055 | c.431C>G | p.Ser144Cys | p.S144C | O95816 | protein_coding | deleterious(0.04) | probably_damaging(0.947) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| BAG2 | insertion | In_Frame_Ins | novel | c.384_385insCTTACT | p.Leu128_Gly129insLeuThr | p.L128_G129insLT | O95816 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| BAG2 | insertion | Nonsense_Mutation | novel | c.385_386insCTCACAGTGTTAAGACTTGATTCAAGTCTTAACACTGT | p.Gly129AlafsTer7 | p.G129Afs*7 | O95816 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| BAG2 | SNV | Missense_Mutation | c.355N>C | p.Glu119Gln | p.E119Q | O95816 | protein_coding | tolerated(0.05) | possibly_damaging(0.625) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| BAG2 | SNV | Missense_Mutation | c.631N>C | p.Asn211His | p.N211H | O95816 | protein_coding | deleterious_low_confidence(0.01) | benign(0.085) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| BAG2 | SNV | Missense_Mutation | novel | c.571T>G | p.Leu191Val | p.L191V | O95816 | protein_coding | deleterious_low_confidence(0.01) | benign(0.437) | TCGA-AA-A00O-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| BAG2 | SNV | Missense_Mutation | c.277A>G | p.Thr93Ala | p.T93A | O95816 | protein_coding | tolerated(0.41) | benign(0.031) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| BAG2 | SNV | Missense_Mutation | rs765872537 | c.257N>A | p.Arg86His | p.R86H | O95816 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
| BAG2 | SNV | Missense_Mutation | novel | c.301A>T | p.Ile101Phe | p.I101F | O95816 | protein_coding | deleterious(0.03) | benign(0.317) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| BAG2 | SNV | Missense_Mutation | novel | c.376N>A | p.Asp126Asn | p.D126N | O95816 | protein_coding | tolerated(0.1) | possibly_damaging(0.783) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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