![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ATP6V0D1 |
Gene summary for ATP6V0D1 |
![]() |
Gene information | Species | Human | Gene symbol | ATP6V0D1 | Gene ID | 9114 |
Gene name | ATPase H+ transporting V0 subunit d1 | |
Gene Alias | ATP6D | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P61421 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9114 | ATP6V0D1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.78e-13 | 7.76e-01 | -0.1808 |
9114 | ATP6V0D1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.19e-14 | 6.00e-01 | -0.1954 |
9114 | ATP6V0D1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.44e-03 | 1.14e+00 | -0.2602 |
9114 | ATP6V0D1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.67e-03 | 6.93e-01 | -0.2196 |
9114 | ATP6V0D1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.58e-05 | 6.58e-01 | -0.1207 |
9114 | ATP6V0D1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.08e-23 | 8.96e-01 | -0.1464 |
9114 | ATP6V0D1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.96e-04 | 4.03e-01 | -0.1001 |
9114 | ATP6V0D1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.72e-04 | 7.12e-01 | -0.1706 |
9114 | ATP6V0D1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.64e-05 | 6.50e-01 | -0.2061 |
9114 | ATP6V0D1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.27e-02 | 3.23e-01 | 0.0674 |
9114 | ATP6V0D1 | A015-C-203 | Human | Colorectum | FAP | 7.16e-04 | -9.60e-02 | -0.1294 |
9114 | ATP6V0D1 | A001-C-108 | Human | Colorectum | FAP | 1.88e-03 | -1.53e-01 | -0.0272 |
9114 | ATP6V0D1 | A002-C-205 | Human | Colorectum | FAP | 4.79e-03 | -1.08e-01 | -0.1236 |
9114 | ATP6V0D1 | A015-C-006 | Human | Colorectum | FAP | 5.46e-03 | -1.83e-01 | -0.0994 |
9114 | ATP6V0D1 | A002-C-114 | Human | Colorectum | FAP | 4.63e-02 | -1.13e-01 | -0.1561 |
9114 | ATP6V0D1 | A015-C-104 | Human | Colorectum | FAP | 1.62e-04 | -1.52e-01 | -0.1899 |
9114 | ATP6V0D1 | A002-C-016 | Human | Colorectum | FAP | 9.72e-03 | -8.09e-02 | 0.0521 |
9114 | ATP6V0D1 | A001-C-203 | Human | Colorectum | FAP | 1.22e-02 | -1.27e-01 | -0.0481 |
9114 | ATP6V0D1 | A002-C-116 | Human | Colorectum | FAP | 1.67e-05 | -1.28e-01 | -0.0452 |
9114 | ATP6V0D1 | A014-C-008 | Human | Colorectum | FAP | 4.56e-03 | -2.05e-01 | -0.191 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00514532 | Colorectum | FAP | regulation of intracellular pH | 22/2622 | 75/18723 | 4.38e-04 | 5.21e-03 | 22 |
GO:00550764 | Colorectum | FAP | transition metal ion homeostasis | 33/2622 | 138/18723 | 1.22e-03 | 1.14e-02 | 33 |
GO:00306413 | Colorectum | FAP | regulation of cellular pH | 22/2622 | 81/18723 | 1.37e-03 | 1.24e-02 | 22 |
GO:00550672 | Colorectum | FAP | monovalent inorganic cation homeostasis | 35/2622 | 151/18723 | 1.58e-03 | 1.40e-02 | 35 |
GO:00068852 | Colorectum | FAP | regulation of pH | 23/2622 | 91/18723 | 3.00e-03 | 2.27e-02 | 23 |
GO:00550723 | Colorectum | FAP | iron ion homeostasis | 21/2622 | 85/18723 | 5.89e-03 | 3.75e-02 | 21 |
GO:00362952 | Colorectum | FAP | cellular response to increased oxygen levels | 6/2622 | 14/18723 | 8.21e-03 | 4.82e-02 | 6 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:0070482111 | Esophagus | ESCC | response to oxygen levels | 218/8552 | 347/18723 | 6.91e-11 | 2.17e-09 | 218 |
GO:001624114 | Esophagus | ESCC | regulation of macroautophagy | 102/8552 | 141/18723 | 1.09e-10 | 3.27e-09 | 102 |
GO:0071453110 | Esophagus | ESCC | cellular response to oxygen levels | 114/8552 | 177/18723 | 3.63e-07 | 5.06e-06 | 114 |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:00070353 | Esophagus | ESCC | vacuolar acidification | 20/8552 | 24/18723 | 1.69e-04 | 1.11e-03 | 20 |
GO:00469169 | Esophagus | ESCC | cellular transition metal ion homeostasis | 70/8552 | 115/18723 | 7.28e-04 | 3.79e-03 | 70 |
GO:00514521 | Esophagus | ESCC | intracellular pH reduction | 29/8552 | 42/18723 | 1.87e-03 | 8.46e-03 | 29 |
GO:00458511 | Esophagus | ESCC | pH reduction | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:00550729 | Esophagus | ESCC | iron ion homeostasis | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa05110 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa051101 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa001902 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa051102 | Colorectum | SER | Vibrio cholerae infection | 24/1580 | 50/8465 | 2.17e-06 | 3.13e-05 | 2.28e-05 | 24 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa001903 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa051103 | Colorectum | SER | Vibrio cholerae infection | 24/1580 | 50/8465 | 2.17e-06 | 3.13e-05 | 2.28e-05 | 24 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa001908 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
hsa051108 | Colorectum | FAP | Vibrio cholerae infection | 19/1404 | 50/8465 | 2.24e-04 | 1.92e-03 | 1.17e-03 | 19 |
hsa001909 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
hsa051109 | Colorectum | FAP | Vibrio cholerae infection | 19/1404 | 50/8465 | 2.24e-04 | 1.92e-03 | 1.17e-03 | 19 |
hsa00190210 | Esophagus | ESCC | Oxidative phosphorylation | 104/4205 | 134/8465 | 2.04e-11 | 2.98e-10 | 1.53e-10 | 104 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0512018 | Esophagus | ESCC | Epithelial cell signaling in Helicobacter pylori infection | 52/4205 | 70/8465 | 2.17e-05 | 1.07e-04 | 5.47e-05 | 52 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
Page: 1 2 3 4 5 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP6V0D1 | SNV | Missense_Mutation | novel | c.368C>T | p.Ala123Val | p.A123V | P61421 | protein_coding | tolerated(0.14) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATP6V0D1 | SNV | Missense_Mutation | c.91N>A | p.Ala31Thr | p.A31T | P61421 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP6V0D1 | SNV | Missense_Mutation | c.386G>A | p.Cys129Tyr | p.C129Y | P61421 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP6V0D1 | SNV | Missense_Mutation | rs747711094 | c.1009N>A | p.Ala337Thr | p.A337T | P61421 | protein_coding | tolerated(0.1) | probably_damaging(0.989) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V0D1 | SNV | Missense_Mutation | rs755703812 | c.829N>T | p.Leu277Phe | p.L277F | P61421 | protein_coding | tolerated(0.89) | probably_damaging(0.992) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V0D1 | SNV | Missense_Mutation | c.994A>T | p.Ile332Phe | p.I332F | P61421 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP6V0D1 | SNV | Missense_Mutation | novel | c.631N>C | p.Ile211Leu | p.I211L | P61421 | protein_coding | tolerated(0.52) | benign(0.015) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ATP6V0D1 | SNV | Missense_Mutation | c.538N>C | p.Ile180Leu | p.I180L | P61421 | protein_coding | tolerated(0.06) | possibly_damaging(0.768) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ATP6V0D1 | SNV | Missense_Mutation | rs765114517 | c.882N>A | p.Phe294Leu | p.F294L | P61421 | protein_coding | deleterious(0.05) | probably_damaging(0.95) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP6V0D1 | SNV | Missense_Mutation | novel | c.988N>A | p.Val330Met | p.V330M | P61421 | protein_coding | tolerated(0.28) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |