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Gene: ATP5PF |
Gene summary for ATP5PF |
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Gene information | Species | Human | Gene symbol | ATP5PF | Gene ID | 522 |
Gene name | ATP synthase peripheral stalk subunit F6 | |
Gene Alias | ATP5 | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0002027 | UniProtAcc | P18859 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
522 | ATP5PF | GSM4909281 | Human | Breast | IDC | 3.80e-19 | 5.51e-01 | 0.21 |
522 | ATP5PF | GSM4909282 | Human | Breast | IDC | 7.83e-37 | 7.74e-01 | -0.0288 |
522 | ATP5PF | GSM4909285 | Human | Breast | IDC | 1.46e-61 | 9.30e-01 | 0.21 |
522 | ATP5PF | GSM4909286 | Human | Breast | IDC | 2.98e-18 | 3.33e-01 | 0.1081 |
522 | ATP5PF | GSM4909287 | Human | Breast | IDC | 2.65e-10 | 4.54e-01 | 0.2057 |
522 | ATP5PF | GSM4909288 | Human | Breast | IDC | 2.82e-04 | 4.98e-01 | 0.0988 |
522 | ATP5PF | GSM4909290 | Human | Breast | IDC | 1.76e-25 | 7.17e-01 | 0.2096 |
522 | ATP5PF | GSM4909291 | Human | Breast | IDC | 4.94e-58 | 1.08e+00 | 0.1753 |
522 | ATP5PF | GSM4909293 | Human | Breast | IDC | 2.28e-24 | 5.55e-01 | 0.1581 |
522 | ATP5PF | GSM4909294 | Human | Breast | IDC | 5.69e-69 | 9.98e-01 | 0.2022 |
522 | ATP5PF | GSM4909296 | Human | Breast | IDC | 2.34e-10 | 4.42e-01 | 0.1524 |
522 | ATP5PF | GSM4909297 | Human | Breast | IDC | 3.12e-11 | 2.03e-01 | 0.1517 |
522 | ATP5PF | GSM4909298 | Human | Breast | IDC | 2.08e-13 | 4.09e-01 | 0.1551 |
522 | ATP5PF | GSM4909299 | Human | Breast | IDC | 4.38e-04 | 2.85e-01 | 0.035 |
522 | ATP5PF | GSM4909300 | Human | Breast | IDC | 2.21e-03 | 2.70e-01 | 0.0334 |
522 | ATP5PF | GSM4909301 | Human | Breast | IDC | 1.52e-36 | 7.47e-01 | 0.1577 |
522 | ATP5PF | GSM4909303 | Human | Breast | IDC | 4.94e-02 | 3.60e-01 | 0.0438 |
522 | ATP5PF | GSM4909304 | Human | Breast | IDC | 5.25e-03 | -6.82e-04 | 0.1636 |
522 | ATP5PF | GSM4909305 | Human | Breast | IDC | 2.39e-09 | 3.37e-01 | 0.0436 |
522 | ATP5PF | GSM4909306 | Human | Breast | IDC | 1.51e-18 | 5.58e-01 | 0.1564 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000906013 | Breast | IDC | aerobic respiration | 61/1434 | 189/18723 | 4.42e-23 | 6.27e-20 | 61 |
GO:000609113 | Breast | IDC | generation of precursor metabolites and energy | 103/1434 | 490/18723 | 1.53e-21 | 1.74e-18 | 103 |
GO:004533313 | Breast | IDC | cellular respiration | 62/1434 | 230/18723 | 5.98e-19 | 4.25e-16 | 62 |
GO:001598013 | Breast | IDC | energy derivation by oxidation of organic compounds | 73/1434 | 318/18723 | 8.70e-18 | 3.80e-15 | 73 |
GO:001598513 | Breast | IDC | energy coupled proton transport, down electrochemical gradient | 16/1434 | 26/18723 | 3.29e-12 | 6.23e-10 | 16 |
GO:001598613 | Breast | IDC | ATP synthesis coupled proton transport | 16/1434 | 26/18723 | 3.29e-12 | 6.23e-10 | 16 |
GO:190260012 | Breast | IDC | proton transmembrane transport | 40/1434 | 157/18723 | 7.34e-12 | 1.34e-09 | 40 |
GO:004277613 | Breast | IDC | mitochondrial ATP synthesis coupled proton transport | 13/1434 | 19/18723 | 5.19e-11 | 7.76e-09 | 13 |
GO:000920614 | Breast | IDC | purine ribonucleoside triphosphate biosynthetic process | 24/1434 | 68/18723 | 7.70e-11 | 1.07e-08 | 24 |
GO:000914514 | Breast | IDC | purine nucleoside triphosphate biosynthetic process | 24/1434 | 69/18723 | 1.10e-10 | 1.38e-08 | 24 |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:000675413 | Breast | IDC | ATP biosynthetic process | 21/1434 | 57/18723 | 4.68e-10 | 5.06e-08 | 21 |
GO:000914214 | Breast | IDC | nucleoside triphosphate biosynthetic process | 26/1434 | 85/18723 | 4.72e-10 | 5.06e-08 | 26 |
GO:000920113 | Breast | IDC | ribonucleoside triphosphate biosynthetic process | 24/1434 | 74/18723 | 5.73e-10 | 6.03e-08 | 24 |
GO:000914414 | Breast | IDC | purine nucleoside triphosphate metabolic process | 26/1434 | 88/18723 | 1.09e-09 | 1.07e-07 | 26 |
GO:000920514 | Breast | IDC | purine ribonucleoside triphosphate metabolic process | 25/1434 | 82/18723 | 1.10e-09 | 1.07e-07 | 25 |
GO:002176214 | Breast | IDC | substantia nigra development | 18/1434 | 44/18723 | 1.11e-09 | 1.07e-07 | 18 |
GO:000914114 | Breast | IDC | nucleoside triphosphate metabolic process | 29/1434 | 112/18723 | 3.68e-09 | 3.03e-07 | 29 |
GO:004885713 | Breast | IDC | neural nucleus development | 21/1434 | 64/18723 | 5.35e-09 | 4.28e-07 | 21 |
GO:000919913 | Breast | IDC | ribonucleoside triphosphate metabolic process | 25/1434 | 89/18723 | 7.22e-09 | 5.47e-07 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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