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Gene: ATAD1 |
Gene summary for ATAD1 |
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Gene information | Species | Human | Gene symbol | ATAD1 | Gene ID | 84896 |
Gene name | ATPase family AAA domain containing 1 | |
Gene Alias | AFDC1 | |
Cytomap | 10q23.31 | |
Gene Type | protein-coding | GO ID | GO:0002090 | UniProtAcc | Q8NBU5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84896 | ATAD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.78e-14 | -5.73e-01 | 0.0155 |
84896 | ATAD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.00e-03 | -4.62e-01 | -0.1808 |
84896 | ATAD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.28e-15 | -4.76e-01 | -0.1464 |
84896 | ATAD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.84e-12 | -4.42e-01 | -0.1001 |
84896 | ATAD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.93e-06 | -4.70e-01 | 0.096 |
84896 | ATAD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.05e-04 | -5.22e-01 | 0.0338 |
84896 | ATAD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.86e-14 | -4.85e-01 | 0.0674 |
84896 | ATAD1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.76e-03 | -5.85e-01 | 0.0112 |
84896 | ATAD1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.21e-03 | -5.25e-01 | 0.0588 |
84896 | ATAD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.12e-03 | -2.66e-01 | 0.294 |
84896 | ATAD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.30e-07 | -3.82e-01 | 0.3859 |
84896 | ATAD1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.56e-02 | -5.27e-01 | 0.2585 |
84896 | ATAD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.90e-16 | -4.81e-01 | 0.3005 |
84896 | ATAD1 | A015-C-203 | Human | Colorectum | FAP | 1.78e-23 | -4.20e-01 | -0.1294 |
84896 | ATAD1 | A015-C-204 | Human | Colorectum | FAP | 2.42e-04 | -3.52e-01 | -0.0228 |
84896 | ATAD1 | A002-C-201 | Human | Colorectum | FAP | 8.61e-09 | -3.90e-01 | 0.0324 |
84896 | ATAD1 | A002-C-203 | Human | Colorectum | FAP | 6.78e-05 | -2.06e-01 | 0.2786 |
84896 | ATAD1 | A001-C-119 | Human | Colorectum | FAP | 7.39e-05 | -3.93e-01 | -0.1557 |
84896 | ATAD1 | A001-C-108 | Human | Colorectum | FAP | 5.02e-13 | -3.51e-01 | -0.0272 |
84896 | ATAD1 | A002-C-205 | Human | Colorectum | FAP | 2.94e-16 | -5.12e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:004580718 | Esophagus | ESCC | positive regulation of endocytosis | 69/8552 | 100/18723 | 1.97e-06 | 2.29e-05 | 69 |
GO:004311218 | Esophagus | ESCC | receptor metabolic process | 104/8552 | 166/18723 | 7.44e-06 | 7.37e-05 | 104 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:004825916 | Esophagus | ESCC | regulation of receptor-mediated endocytosis | 66/8552 | 110/18723 | 1.72e-03 | 7.96e-03 | 66 |
GO:004826010 | Esophagus | ESCC | positive regulation of receptor-mediated endocytosis | 34/8552 | 52/18723 | 3.26e-03 | 1.35e-02 | 34 |
GO:00068984 | Liver | NAFLD | receptor-mediated endocytosis | 49/1882 | 244/18723 | 1.80e-06 | 7.78e-05 | 49 |
GO:00458074 | Liver | NAFLD | positive regulation of endocytosis | 25/1882 | 100/18723 | 1.34e-05 | 3.97e-04 | 25 |
GO:00482604 | Liver | NAFLD | positive regulation of receptor-mediated endocytosis | 16/1882 | 52/18723 | 3.13e-05 | 8.20e-04 | 16 |
GO:00431124 | Liver | NAFLD | receptor metabolic process | 31/1882 | 166/18723 | 5.10e-04 | 7.15e-03 | 31 |
GO:00482594 | Liver | NAFLD | regulation of receptor-mediated endocytosis | 23/1882 | 110/18723 | 5.16e-04 | 7.15e-03 | 23 |
GO:00301005 | Liver | NAFLD | regulation of endocytosis | 35/1882 | 211/18723 | 2.09e-03 | 2.06e-02 | 35 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:000689811 | Liver | Cirrhotic | receptor-mediated endocytosis | 91/4634 | 244/18723 | 8.13e-06 | 1.22e-04 | 91 |
GO:003010011 | Liver | Cirrhotic | regulation of endocytosis | 74/4634 | 211/18723 | 4.86e-04 | 3.90e-03 | 74 |
GO:004311211 | Liver | Cirrhotic | receptor metabolic process | 59/4634 | 166/18723 | 1.19e-03 | 8.07e-03 | 59 |
GO:004580711 | Liver | Cirrhotic | positive regulation of endocytosis | 38/4634 | 100/18723 | 2.22e-03 | 1.35e-02 | 38 |
GO:004825911 | Liver | Cirrhotic | regulation of receptor-mediated endocytosis | 39/4634 | 110/18723 | 7.76e-03 | 3.65e-02 | 39 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATAD1 | SNV | Missense_Mutation | novel | c.134G>A | p.Arg45Lys | p.R45K | Q8NBU5 | protein_coding | tolerated(0.37) | benign(0.027) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
ATAD1 | SNV | Missense_Mutation | c.238N>T | p.Leu80Phe | p.L80F | Q8NBU5 | protein_coding | tolerated(0.08) | possibly_damaging(0.533) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATAD1 | SNV | Missense_Mutation | novel | c.37N>T | p.Arg13Trp | p.R13W | Q8NBU5 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD |
ATAD1 | SNV | Missense_Mutation | novel | c.682N>G | p.Ser228Gly | p.S228G | Q8NBU5 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-AA-3972-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
ATAD1 | SNV | Missense_Mutation | rs780964486 | c.716N>A | p.Arg239His | p.R239H | Q8NBU5 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | c.188G>A | p.Gly63Glu | p.G63E | Q8NBU5 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATAD1 | SNV | Missense_Mutation | novel | c.1026N>T | p.Lys342Asn | p.K342N | Q8NBU5 | protein_coding | deleterious(0.03) | benign(0.051) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | novel | c.313N>T | p.Asp105Tyr | p.D105Y | Q8NBU5 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | c.490N>A | p.Asp164Asn | p.D164N | Q8NBU5 | protein_coding | deleterious(0.05) | probably_damaging(0.969) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ATAD1 | SNV | Missense_Mutation | novel | c.773A>C | p.Asn258Thr | p.N258T | Q8NBU5 | protein_coding | tolerated(0.1) | benign(0.216) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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