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Gene: ARL2BP |
Gene summary for ARL2BP |
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Gene information | Species | Human | Gene symbol | ARL2BP | Gene ID | 23568 |
Gene name | ADP ribosylation factor like GTPase 2 binding protein | |
Gene Alias | BART | |
Cytomap | 16q13 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | A0A024R6U9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23568 | ARL2BP | LZE2T | Human | Esophagus | ESCC | 2.06e-02 | 4.43e-01 | 0.082 |
23568 | ARL2BP | LZE4T | Human | Esophagus | ESCC | 4.56e-16 | 7.30e-01 | 0.0811 |
23568 | ARL2BP | LZE7T | Human | Esophagus | ESCC | 2.93e-04 | 6.05e-01 | 0.0667 |
23568 | ARL2BP | LZE8T | Human | Esophagus | ESCC | 1.15e-06 | 1.36e-01 | 0.067 |
23568 | ARL2BP | LZE20T | Human | Esophagus | ESCC | 1.40e-06 | 2.52e-01 | 0.0662 |
23568 | ARL2BP | LZE22T | Human | Esophagus | ESCC | 8.17e-06 | 6.79e-01 | 0.068 |
23568 | ARL2BP | LZE24T | Human | Esophagus | ESCC | 3.88e-30 | 8.04e-01 | 0.0596 |
23568 | ARL2BP | P1T-E | Human | Esophagus | ESCC | 3.18e-12 | 1.02e+00 | 0.0875 |
23568 | ARL2BP | P2T-E | Human | Esophagus | ESCC | 9.79e-45 | 7.34e-01 | 0.1177 |
23568 | ARL2BP | P4T-E | Human | Esophagus | ESCC | 5.31e-46 | 1.11e+00 | 0.1323 |
23568 | ARL2BP | P5T-E | Human | Esophagus | ESCC | 1.47e-31 | 7.16e-01 | 0.1327 |
23568 | ARL2BP | P8T-E | Human | Esophagus | ESCC | 4.98e-46 | 7.72e-01 | 0.0889 |
23568 | ARL2BP | P9T-E | Human | Esophagus | ESCC | 1.31e-27 | 6.37e-01 | 0.1131 |
23568 | ARL2BP | P10T-E | Human | Esophagus | ESCC | 7.78e-29 | 6.60e-01 | 0.116 |
23568 | ARL2BP | P11T-E | Human | Esophagus | ESCC | 1.43e-35 | 1.26e+00 | 0.1426 |
23568 | ARL2BP | P12T-E | Human | Esophagus | ESCC | 3.68e-32 | 6.66e-01 | 0.1122 |
23568 | ARL2BP | P15T-E | Human | Esophagus | ESCC | 8.99e-29 | 7.08e-01 | 0.1149 |
23568 | ARL2BP | P16T-E | Human | Esophagus | ESCC | 1.27e-24 | 3.75e-01 | 0.1153 |
23568 | ARL2BP | P17T-E | Human | Esophagus | ESCC | 3.87e-12 | 6.62e-01 | 0.1278 |
23568 | ARL2BP | P19T-E | Human | Esophagus | ESCC | 5.42e-22 | 1.39e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034504110 | Skin | cSCC | protein localization to nucleus | 143/4864 | 290/18723 | 8.98e-18 | 1.02e-15 | 143 |
GO:0045185112 | Skin | cSCC | maintenance of protein location | 49/4864 | 94/18723 | 5.46e-08 | 1.40e-06 | 49 |
GO:0032507111 | Skin | cSCC | maintenance of protein location in cell | 37/4864 | 65/18723 | 1.20e-07 | 2.79e-06 | 37 |
GO:007259510 | Skin | cSCC | maintenance of protein localization in organelle | 25/4864 | 42/18723 | 4.45e-06 | 6.57e-05 | 25 |
GO:00514576 | Skin | cSCC | maintenance of protein location in nucleus | 14/4864 | 23/18723 | 4.32e-04 | 3.34e-03 | 14 |
GO:005123527 | Skin | cSCC | maintenance of location | 106/4864 | 327/18723 | 5.17e-03 | 2.61e-02 | 106 |
GO:005165128 | Skin | cSCC | maintenance of location in cell | 72/4864 | 214/18723 | 7.37e-03 | 3.47e-02 | 72 |
GO:0034504111 | Thyroid | PTC | protein localization to nucleus | 170/5968 | 290/18723 | 3.34e-21 | 6.38e-19 | 170 |
GO:0045185113 | Thyroid | PTC | maintenance of protein location | 64/5968 | 94/18723 | 5.92e-13 | 2.85e-11 | 64 |
GO:0032507112 | Thyroid | PTC | maintenance of protein location in cell | 47/5968 | 65/18723 | 2.54e-11 | 9.66e-10 | 47 |
GO:007259519 | Thyroid | PTC | maintenance of protein localization in organelle | 33/5968 | 42/18723 | 6.30e-10 | 1.97e-08 | 33 |
GO:0051235112 | Thyroid | PTC | maintenance of location | 148/5968 | 327/18723 | 2.30e-07 | 4.07e-06 | 148 |
GO:005145713 | Thyroid | PTC | maintenance of protein location in nucleus | 19/5968 | 23/18723 | 7.60e-07 | 1.18e-05 | 19 |
GO:0051651113 | Thyroid | PTC | maintenance of location in cell | 100/5968 | 214/18723 | 3.65e-06 | 4.67e-05 | 100 |
GO:00182126 | Thyroid | PTC | peptidyl-tyrosine modification | 142/5968 | 378/18723 | 1.02e-02 | 4.14e-02 | 142 |
GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
GO:004518532 | Thyroid | ATC | maintenance of protein location | 64/6293 | 94/18723 | 8.44e-12 | 3.16e-10 | 64 |
GO:003250732 | Thyroid | ATC | maintenance of protein location in cell | 47/6293 | 65/18723 | 1.98e-10 | 5.86e-09 | 47 |
GO:007259532 | Thyroid | ATC | maintenance of protein localization in organelle | 33/6293 | 42/18723 | 2.92e-09 | 6.88e-08 | 33 |
GO:005123532 | Thyroid | ATC | maintenance of location | 152/6293 | 327/18723 | 7.84e-07 | 1.04e-05 | 152 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL2BP | SNV | Missense_Mutation | novel | c.328N>A | p.Asp110Asn | p.D110N | Q9Y2Y0 | protein_coding | tolerated(0.28) | benign(0.02) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ARL2BP | SNV | Missense_Mutation | c.46N>A | p.Ala16Thr | p.A16T | Q9Y2Y0 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL2BP | SNV | Missense_Mutation | c.46G>A | p.Ala16Thr | p.A16T | Q9Y2Y0 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL2BP | SNV | Missense_Mutation | c.184T>C | p.Tyr62His | p.Y62H | Q9Y2Y0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL2BP | SNV | Missense_Mutation | c.212C>A | p.Ser71Tyr | p.S71Y | Q9Y2Y0 | protein_coding | tolerated(0.11) | benign(0.072) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ARL2BP | SNV | Missense_Mutation | novel | c.415N>G | p.Leu139Val | p.L139V | Q9Y2Y0 | protein_coding | deleterious(0.05) | benign(0.219) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARL2BP | SNV | Missense_Mutation | c.451N>C | p.Ser151Pro | p.S151P | Q9Y2Y0 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ARL2BP | SNV | Missense_Mutation | rs147277394 | c.132N>A | p.Phe44Leu | p.F44L | Q9Y2Y0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARL2BP | SNV | Missense_Mutation | rs778187320 | c.458N>T | p.Ser153Phe | p.S153F | Q9Y2Y0 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD |
ARL2BP | SNV | Missense_Mutation | c.386N>A | p.Arg129Lys | p.R129K | Q9Y2Y0 | protein_coding | tolerated(0.45) | benign(0.027) | TCGA-55-7903-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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