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Gene: ARID4A |
Gene summary for ARID4A |
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Gene information | Species | Human | Gene symbol | ARID4A | Gene ID | 5926 |
Gene name | AT-rich interaction domain 4A | |
Gene Alias | RBBP-1 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R657 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5926 | ARID4A | LZE4T | Human | Esophagus | ESCC | 1.71e-15 | 6.02e-01 | 0.0811 |
5926 | ARID4A | LZE8T | Human | Esophagus | ESCC | 4.84e-02 | 1.54e-01 | 0.067 |
5926 | ARID4A | LZE20T | Human | Esophagus | ESCC | 1.35e-10 | 5.50e-01 | 0.0662 |
5926 | ARID4A | LZE22T | Human | Esophagus | ESCC | 5.91e-03 | 4.38e-01 | 0.068 |
5926 | ARID4A | LZE24T | Human | Esophagus | ESCC | 4.92e-13 | 3.15e-01 | 0.0596 |
5926 | ARID4A | LZE21T | Human | Esophagus | ESCC | 4.11e-02 | 2.66e-01 | 0.0655 |
5926 | ARID4A | P1T-E | Human | Esophagus | ESCC | 2.27e-11 | 5.97e-01 | 0.0875 |
5926 | ARID4A | P2T-E | Human | Esophagus | ESCC | 3.64e-27 | 5.13e-01 | 0.1177 |
5926 | ARID4A | P4T-E | Human | Esophagus | ESCC | 1.65e-29 | 7.03e-01 | 0.1323 |
5926 | ARID4A | P5T-E | Human | Esophagus | ESCC | 2.73e-22 | 4.23e-01 | 0.1327 |
5926 | ARID4A | P8T-E | Human | Esophagus | ESCC | 1.35e-33 | 6.74e-01 | 0.0889 |
5926 | ARID4A | P9T-E | Human | Esophagus | ESCC | 1.50e-12 | 3.24e-01 | 0.1131 |
5926 | ARID4A | P10T-E | Human | Esophagus | ESCC | 1.43e-38 | 6.76e-01 | 0.116 |
5926 | ARID4A | P11T-E | Human | Esophagus | ESCC | 3.68e-13 | 7.27e-01 | 0.1426 |
5926 | ARID4A | P12T-E | Human | Esophagus | ESCC | 1.18e-44 | 8.05e-01 | 0.1122 |
5926 | ARID4A | P15T-E | Human | Esophagus | ESCC | 2.36e-55 | 1.23e+00 | 0.1149 |
5926 | ARID4A | P16T-E | Human | Esophagus | ESCC | 5.89e-37 | 6.95e-01 | 0.1153 |
5926 | ARID4A | P17T-E | Human | Esophagus | ESCC | 7.58e-03 | 1.99e-01 | 0.1278 |
5926 | ARID4A | P20T-E | Human | Esophagus | ESCC | 1.58e-22 | 6.19e-01 | 0.1124 |
5926 | ARID4A | P21T-E | Human | Esophagus | ESCC | 3.71e-13 | 2.10e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000206412 | Liver | Cirrhotic | epithelial cell development | 80/4634 | 220/18723 | 7.63e-05 | 8.44e-04 | 80 |
GO:000226212 | Liver | Cirrhotic | myeloid cell homeostasis | 59/4634 | 157/18723 | 2.33e-04 | 2.11e-03 | 59 |
GO:004887212 | Liver | Cirrhotic | homeostasis of number of cells | 89/4634 | 272/18723 | 1.76e-03 | 1.12e-02 | 89 |
GO:00614585 | Liver | Cirrhotic | reproductive system development | 132/4634 | 427/18723 | 2.07e-03 | 1.28e-02 | 132 |
GO:00486085 | Liver | Cirrhotic | reproductive structure development | 131/4634 | 424/18723 | 2.19e-03 | 1.34e-02 | 131 |
GO:006000911 | Liver | Cirrhotic | Sertoli cell development | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:00064791 | Liver | Cirrhotic | protein methylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00082131 | Liver | Cirrhotic | protein alkylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00165711 | Liver | Cirrhotic | histone methylation | 49/4634 | 141/18723 | 4.90e-03 | 2.56e-02 | 49 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00082132 | Liver | HCC | protein alkylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00165712 | Liver | HCC | histone methylation | 88/7958 | 141/18723 | 1.41e-06 | 2.02e-05 | 88 |
GO:003410122 | Liver | HCC | erythrocyte homeostasis | 79/7958 | 129/18723 | 1.32e-05 | 1.47e-04 | 79 |
GO:000226222 | Liver | HCC | myeloid cell homeostasis | 93/7958 | 157/18723 | 1.67e-05 | 1.81e-04 | 93 |
GO:003021812 | Liver | HCC | erythrocyte differentiation | 73/7958 | 120/18723 | 3.82e-05 | 3.80e-04 | 73 |
GO:003009922 | Liver | HCC | myeloid cell differentiation | 200/7958 | 381/18723 | 4.64e-05 | 4.49e-04 | 200 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARID4A | SNV | Missense_Mutation | c.962A>G | p.Lys321Arg | p.K321R | P29374 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARID4A | SNV | Missense_Mutation | c.3109C>G | p.Gln1037Glu | p.Q1037E | P29374 | protein_coding | tolerated(0.11) | benign(0.107) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARID4A | SNV | Missense_Mutation | c.2476N>T | p.His826Tyr | p.H826Y | P29374 | protein_coding | deleterious_low_confidence(0.01) | benign(0.013) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARID4A | SNV | Missense_Mutation | novel | c.375N>T | p.Leu125Phe | p.L125F | P29374 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ARID4A | deletion | In_Frame_Del | c.1948_1962delNNNNNNNNNNNNNNN | p.Asp650_Asp654del | p.D650_D654del | P29374 | protein_coding | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
ARID4A | insertion | Frame_Shift_Ins | novel | c.1920dupA | p.Gln641ThrfsTer6 | p.Q641Tfs*6 | P29374 | protein_coding | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | ||
ARID4A | deletion | Frame_Shift_Del | novel | c.1915delN | p.Lys640AsnfsTer32 | p.K640Nfs*32 | P29374 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ARID4A | SNV | Missense_Mutation | novel | c.3665N>T | p.Arg1222Met | p.R1222M | P29374 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARID4A | SNV | Missense_Mutation | c.1525A>G | p.Thr509Ala | p.T509A | P29374 | protein_coding | tolerated(0.26) | benign(0) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ARID4A | SNV | Missense_Mutation | rs760395662 | c.2281G>C | p.Glu761Gln | p.E761Q | P29374 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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