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Gene: ARHGAP1 |
Gene summary for ARHGAP1 |
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Gene information | Species | Human | Gene symbol | ARHGAP1 | Gene ID | 392 |
Gene name | Rho GTPase activating protein 1 | |
Gene Alias | CDC42GAP | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q07960 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
392 | ARHGAP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.91e-05 | 2.18e-01 | 0.0155 |
392 | ARHGAP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.96e-09 | 5.33e-01 | -0.1808 |
392 | ARHGAP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.17e-11 | 5.57e-01 | -0.0811 |
392 | ARHGAP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.96e-09 | 5.32e-01 | -0.1088 |
392 | ARHGAP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.43e-26 | 6.78e-01 | -0.1954 |
392 | ARHGAP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.25e-10 | 1.15e+00 | -0.2602 |
392 | ARHGAP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.35e-06 | 7.08e-01 | -0.2196 |
392 | ARHGAP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-08 | 5.66e-01 | -0.1207 |
392 | ARHGAP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.25e-07 | 5.20e-01 | -0.1526 |
392 | ARHGAP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.18e-18 | 7.14e-01 | -0.1464 |
392 | ARHGAP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.47e-13 | 5.40e-01 | -0.1001 |
392 | ARHGAP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.91e-19 | 6.82e-01 | -0.059 |
392 | ARHGAP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.18e-02 | 5.35e-01 | -0.1706 |
392 | ARHGAP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.65e-06 | 5.45e-01 | -0.0842 |
392 | ARHGAP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.87e-04 | 2.54e-01 | 0.096 |
392 | ARHGAP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.13e-02 | 4.16e-01 | 0.0446 |
392 | ARHGAP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.00e-03 | 5.19e-01 | 0.0528 |
392 | ARHGAP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.40e-03 | 4.13e-01 | 0.0131 |
392 | ARHGAP1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.10e-02 | 3.49e-01 | -0.0177 |
392 | ARHGAP1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.31e-03 | 5.23e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0016601 | Colorectum | AD | Rac protein signal transduction | 20/3918 | 42/18723 | 1.02e-04 | 1.53e-03 | 20 |
GO:0032456 | Colorectum | AD | endocytic recycling | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0033572 | Colorectum | AD | transferrin transport | 7/3918 | 10/18723 | 1.15e-03 | 1.04e-02 | 7 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0051058 | Colorectum | AD | negative regulation of small GTPase mediated signal transduction | 21/3918 | 56/18723 | 3.26e-03 | 2.39e-02 | 21 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00988761 | Colorectum | SER | vesicle-mediated transport to the plasma membrane | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00329702 | Colorectum | MSS | regulation of actin filament-based process | 128/3467 | 397/18723 | 2.47e-11 | 3.49e-09 | 128 |
GO:00329562 | Colorectum | MSS | regulation of actin cytoskeleton organization | 113/3467 | 358/18723 | 1.46e-09 | 1.07e-07 | 113 |
GO:00988762 | Colorectum | MSS | vesicle-mediated transport to the plasma membrane | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00323862 | Colorectum | MSS | regulation of intracellular transport | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP1 | SNV | Missense_Mutation | c.730N>T | p.Val244Phe | p.V244F | Q07960 | protein_coding | deleterious(0) | possibly_damaging(0.713) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP1 | SNV | Missense_Mutation | rs760960194 | c.205N>T | p.Arg69Trp | p.R69W | Q07960 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | deletion | Frame_Shift_Del | novel | c.178_179delNN | p.Trp60GlyfsTer2 | p.W60Gfs*2 | Q07960 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ARHGAP1 | SNV | Missense_Mutation | rs764362910 | c.394N>A | p.Asp132Asn | p.D132N | Q07960 | protein_coding | tolerated(0.16) | benign(0.01) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.421N>T | p.Arg141Cys | p.R141C | Q07960 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.232N>T | p.Asp78Tyr | p.D78Y | Q07960 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.1253C>T | p.Thr418Ile | p.T418I | Q07960 | protein_coding | tolerated(0.43) | benign(0.023) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | c.1222A>G | p.Ile408Val | p.I408V | Q07960 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ARHGAP1 | SNV | Missense_Mutation | rs754102804 | c.872N>A | p.Arg291Gln | p.R291Q | Q07960 | protein_coding | tolerated(0.07) | benign(0.173) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.1145N>A | p.Ser382Asn | p.S382N | Q07960 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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