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Gene: ALDOB |
Gene summary for ALDOB |
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Gene information | Species | Human | Gene symbol | ALDOB | Gene ID | 229 |
Gene name | aldolase, fructose-bisphosphate B | |
Gene Alias | ALDB | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024R145 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
229 | ALDOB | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.66e-11 | 8.90e-01 | -0.1808 |
229 | ALDOB | HTA11_411_2000001011 | Human | Colorectum | SER | 6.98e-04 | 1.22e+00 | -0.2602 |
229 | ALDOB | HTA11_696_2000001011 | Human | Colorectum | AD | 1.53e-07 | 3.62e-01 | -0.1464 |
229 | ALDOB | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.43e-06 | 5.69e-01 | -0.059 |
229 | ALDOB | NAFLD1 | Human | Liver | NAFLD | 5.25e-10 | 1.20e+00 | -0.04 |
229 | ALDOB | S41 | Human | Liver | Cirrhotic | 3.12e-16 | 1.23e+00 | -0.0343 |
229 | ALDOB | S42 | Human | Liver | HCC | 4.45e-12 | 1.28e+00 | -0.0103 |
229 | ALDOB | S43 | Human | Liver | Cirrhotic | 1.09e-17 | 6.78e-01 | -0.0187 |
229 | ALDOB | HCC1_Meng | Human | Liver | HCC | 6.50e-21 | -5.35e-01 | 0.0246 |
229 | ALDOB | HCC2_Meng | Human | Liver | HCC | 3.09e-15 | -5.28e-01 | 0.0107 |
229 | ALDOB | cirrhotic1 | Human | Liver | Cirrhotic | 6.18e-06 | -4.15e-01 | 0.0202 |
229 | ALDOB | cirrhotic2 | Human | Liver | Cirrhotic | 7.17e-05 | -3.61e-01 | 0.0201 |
229 | ALDOB | cirrhotic3 | Human | Liver | Cirrhotic | 1.71e-05 | -5.02e-01 | 0.0215 |
229 | ALDOB | HCC1 | Human | Liver | HCC | 1.43e-14 | 4.38e+00 | 0.5336 |
229 | ALDOB | HCC2 | Human | Liver | HCC | 1.41e-42 | 5.89e+00 | 0.5341 |
229 | ALDOB | Pt13.a | Human | Liver | HCC | 2.04e-25 | 4.01e-01 | 0.021 |
229 | ALDOB | Pt13.b | Human | Liver | HCC | 2.75e-43 | 3.74e-01 | 0.0251 |
229 | ALDOB | Pt14.b | Human | Liver | HCC | 7.12e-08 | 1.42e-01 | 0.018 |
229 | ALDOB | Pt14.d | Human | Liver | HCC | 1.62e-03 | -7.40e-02 | 0.0143 |
229 | ALDOB | S014 | Human | Liver | HCC | 2.43e-06 | -5.73e-01 | 0.2254 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00193181 | Colorectum | SER | hexose metabolic process | 56/2897 | 237/18723 | 6.19e-04 | 8.42e-03 | 56 |
GO:00067341 | Colorectum | SER | NADH metabolic process | 12/2897 | 29/18723 | 7.22e-04 | 9.44e-03 | 12 |
GO:00460311 | Colorectum | SER | ADP metabolic process | 26/2897 | 90/18723 | 8.77e-04 | 1.06e-02 | 26 |
GO:00059961 | Colorectum | SER | monosaccharide metabolic process | 59/2897 | 257/18723 | 9.65e-04 | 1.15e-02 | 59 |
GO:00469391 | Colorectum | SER | nucleotide phosphorylation | 28/2897 | 101/18723 | 1.15e-03 | 1.31e-02 | 28 |
GO:00061651 | Colorectum | SER | nucleoside diphosphate phosphorylation | 27/2897 | 99/18723 | 1.81e-03 | 1.86e-02 | 27 |
GO:00160521 | Colorectum | SER | carbohydrate catabolic process | 38/2897 | 154/18723 | 1.92e-03 | 1.93e-02 | 38 |
GO:00092596 | Liver | NAFLD | ribonucleotide metabolic process | 72/1882 | 385/18723 | 1.51e-07 | 1.09e-05 | 72 |
GO:00196936 | Liver | NAFLD | ribose phosphate metabolic process | 73/1882 | 396/18723 | 2.23e-07 | 1.53e-05 | 73 |
GO:00059965 | Liver | NAFLD | monosaccharide metabolic process | 53/1882 | 257/18723 | 2.89e-07 | 1.92e-05 | 53 |
GO:00091177 | Liver | NAFLD | nucleotide metabolic process | 85/1882 | 489/18723 | 3.31e-07 | 2.18e-05 | 85 |
GO:00067537 | Liver | NAFLD | nucleoside phosphate metabolic process | 85/1882 | 497/18723 | 6.69e-07 | 3.83e-05 | 85 |
GO:00060917 | Liver | NAFLD | generation of precursor metabolites and energy | 84/1882 | 490/18723 | 7.03e-07 | 3.95e-05 | 84 |
GO:00193185 | Liver | NAFLD | hexose metabolic process | 49/1882 | 237/18723 | 7.41e-07 | 4.12e-05 | 49 |
GO:00725217 | Liver | NAFLD | purine-containing compound metabolic process | 74/1882 | 416/18723 | 7.73e-07 | 4.27e-05 | 74 |
GO:00091507 | Liver | NAFLD | purine ribonucleotide metabolic process | 67/1882 | 368/18723 | 1.10e-06 | 5.44e-05 | 67 |
GO:00091857 | Liver | NAFLD | ribonucleoside diphosphate metabolic process | 28/1882 | 106/18723 | 1.29e-06 | 6.02e-05 | 28 |
GO:00061637 | Liver | NAFLD | purine nucleotide metabolic process | 70/1882 | 396/18723 | 1.93e-06 | 8.23e-05 | 70 |
GO:00091357 | Liver | NAFLD | purine nucleoside diphosphate metabolic process | 26/1882 | 103/18723 | 7.51e-06 | 2.55e-04 | 26 |
GO:00091797 | Liver | NAFLD | purine ribonucleoside diphosphate metabolic process | 26/1882 | 103/18723 | 7.51e-06 | 2.55e-04 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa040662 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa000102 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa012302 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa012003 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa040663 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa000103 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa012303 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa0120010 | Liver | NAFLD | Carbon metabolism | 26/1043 | 115/8465 | 1.39e-03 | 1.71e-02 | 1.38e-02 | 26 |
hsa0120011 | Liver | NAFLD | Carbon metabolism | 26/1043 | 115/8465 | 1.39e-03 | 1.71e-02 | 1.38e-02 | 26 |
hsa0120021 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa000109 | Liver | Cirrhotic | Glycolysis / Gluconeogenesis | 32/2530 | 67/8465 | 1.50e-03 | 7.80e-03 | 4.81e-03 | 32 |
hsa012304 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
hsa0406612 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa00030 | Liver | Cirrhotic | Pentose phosphate pathway | 16/2530 | 30/8465 | 6.04e-03 | 2.12e-02 | 1.30e-02 | 16 |
hsa0120031 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa0001012 | Liver | Cirrhotic | Glycolysis / Gluconeogenesis | 32/2530 | 67/8465 | 1.50e-03 | 7.80e-03 | 4.81e-03 | 32 |
hsa0123011 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDOB | SNV | Missense_Mutation | c.1043N>T | p.Ser348Phe | p.S348F | P05062 | protein_coding | deleterious(0.05) | benign(0.364) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ALDOB | SNV | Missense_Mutation | rs17852652 | c.487G>A | p.Ala163Thr | p.A163T | P05062 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDOB | SNV | Missense_Mutation | c.50N>T | p.Ser17Leu | p.S17L | P05062 | protein_coding | tolerated(0.46) | benign(0.046) | TCGA-C8-A1HG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ALDOB | SNV | Missense_Mutation | rs371526091 | c.992G>A | p.Arg331Gln | p.R331Q | P05062 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ALDOB | SNV | Missense_Mutation | rs150407710 | c.991C>T | p.Arg331Trp | p.R331W | P05062 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ALDOB | SNV | Missense_Mutation | novel | c.829N>A | p.Glu277Lys | p.E277K | P05062 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ALDOB | SNV | Missense_Mutation | c.162N>T | p.Glu54Asp | p.E54D | P05062 | protein_coding | tolerated(0.1) | benign(0.113) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
ALDOB | SNV | Missense_Mutation | c.944N>C | p.Gly315Ala | p.G315A | P05062 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ALDOB | SNV | Missense_Mutation | novel | c.482G>T | p.Ser161Ile | p.S161I | P05062 | protein_coding | tolerated(0.18) | benign(0.095) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ALDOB | SNV | Missense_Mutation | c.916N>A | p.Leu306Met | p.L306M | P05062 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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