![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AKIRIN1 |
Gene summary for AKIRIN1 |
![]() |
Gene information | Species | Human | Gene symbol | AKIRIN1 | Gene ID | 79647 |
Gene name | akirin 1 | |
Gene Alias | C1orf108 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9H9L7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79647 | AKIRIN1 | LZE4T | Human | Esophagus | ESCC | 3.46e-10 | -9.14e-02 | 0.0811 |
79647 | AKIRIN1 | LZE8T | Human | Esophagus | ESCC | 8.03e-11 | -1.88e-01 | 0.067 |
79647 | AKIRIN1 | LZE20T | Human | Esophagus | ESCC | 1.07e-13 | -1.49e-01 | 0.0662 |
79647 | AKIRIN1 | LZE22D1 | Human | Esophagus | HGIN | 5.89e-04 | -2.18e-01 | 0.0595 |
79647 | AKIRIN1 | LZE22T | Human | Esophagus | ESCC | 1.03e-03 | 1.85e-01 | 0.068 |
79647 | AKIRIN1 | LZE24T | Human | Esophagus | ESCC | 9.76e-15 | 5.15e-01 | 0.0596 |
79647 | AKIRIN1 | LZE6T | Human | Esophagus | ESCC | 2.30e-02 | -2.44e-01 | 0.0845 |
79647 | AKIRIN1 | P2T-E | Human | Esophagus | ESCC | 5.58e-32 | 7.10e-01 | 0.1177 |
79647 | AKIRIN1 | P4T-E | Human | Esophagus | ESCC | 1.44e-20 | 3.42e-01 | 0.1323 |
79647 | AKIRIN1 | P5T-E | Human | Esophagus | ESCC | 7.97e-12 | 3.53e-01 | 0.1327 |
79647 | AKIRIN1 | P8T-E | Human | Esophagus | ESCC | 1.41e-11 | 1.94e-01 | 0.0889 |
79647 | AKIRIN1 | P9T-E | Human | Esophagus | ESCC | 4.21e-17 | 1.22e-01 | 0.1131 |
79647 | AKIRIN1 | P10T-E | Human | Esophagus | ESCC | 3.63e-25 | 5.98e-01 | 0.116 |
79647 | AKIRIN1 | P11T-E | Human | Esophagus | ESCC | 6.66e-06 | 2.42e-01 | 0.1426 |
79647 | AKIRIN1 | P12T-E | Human | Esophagus | ESCC | 1.57e-12 | 3.83e-01 | 0.1122 |
79647 | AKIRIN1 | P15T-E | Human | Esophagus | ESCC | 4.11e-22 | 4.91e-01 | 0.1149 |
79647 | AKIRIN1 | P16T-E | Human | Esophagus | ESCC | 3.14e-23 | 3.37e-01 | 0.1153 |
79647 | AKIRIN1 | P17T-E | Human | Esophagus | ESCC | 1.33e-03 | 2.22e-01 | 0.1278 |
79647 | AKIRIN1 | P19T-E | Human | Esophagus | ESCC | 3.88e-06 | 5.61e-01 | 0.1662 |
79647 | AKIRIN1 | P20T-E | Human | Esophagus | ESCC | 7.13e-21 | 4.84e-01 | 0.1124 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006049112 | Liver | HCC | regulation of cell projection assembly | 101/7958 | 188/18723 | 1.20e-03 | 6.69e-03 | 101 |
GO:012003212 | Liver | HCC | regulation of plasma membrane bounded cell projection assembly | 100/7958 | 186/18723 | 1.23e-03 | 6.81e-03 | 100 |
GO:01200344 | Liver | HCC | positive regulation of plasma membrane bounded cell projection assembly | 58/7958 | 105/18723 | 5.66e-03 | 2.36e-02 | 58 |
GO:001059111 | Liver | HCC | regulation of lamellipodium assembly | 26/7958 | 42/18723 | 8.76e-03 | 3.41e-02 | 26 |
GO:00310999 | Oral cavity | OSCC | regeneration | 114/7305 | 198/18723 | 8.54e-08 | 1.50e-06 | 114 |
GO:000268714 | Oral cavity | OSCC | positive regulation of leukocyte migration | 78/7305 | 135/18723 | 7.43e-06 | 8.08e-05 | 78 |
GO:003134610 | Oral cavity | OSCC | positive regulation of cell projection organization | 176/7305 | 353/18723 | 1.94e-05 | 1.87e-04 | 176 |
GO:009758110 | Oral cavity | OSCC | lamellipodium organization | 54/7305 | 90/18723 | 4.39e-05 | 3.76e-04 | 54 |
GO:006049110 | Oral cavity | OSCC | regulation of cell projection assembly | 100/7305 | 188/18723 | 5.27e-05 | 4.38e-04 | 100 |
GO:012003216 | Oral cavity | OSCC | regulation of plasma membrane bounded cell projection assembly | 98/7305 | 186/18723 | 1.00e-04 | 7.54e-04 | 98 |
GO:000268510 | Oral cavity | OSCC | regulation of leukocyte migration | 108/7305 | 210/18723 | 1.63e-04 | 1.13e-03 | 108 |
GO:00321037 | Oral cavity | OSCC | positive regulation of response to external stimulus | 203/7305 | 427/18723 | 1.79e-04 | 1.22e-03 | 203 |
GO:00509216 | Oral cavity | OSCC | positive regulation of chemotaxis | 76/7305 | 141/18723 | 2.30e-04 | 1.49e-03 | 76 |
GO:005090010 | Oral cavity | OSCC | leukocyte migration | 176/7305 | 369/18723 | 3.80e-04 | 2.31e-03 | 176 |
GO:00026908 | Oral cavity | OSCC | positive regulation of leukocyte chemotaxis | 53/7305 | 94/18723 | 4.71e-04 | 2.79e-03 | 53 |
GO:00422464 | Oral cavity | OSCC | tissue regeneration | 42/7305 | 72/18723 | 6.89e-04 | 3.84e-03 | 42 |
GO:00300328 | Oral cavity | OSCC | lamellipodium assembly | 41/7305 | 72/18723 | 1.53e-03 | 7.31e-03 | 41 |
GO:00603269 | Oral cavity | OSCC | cell chemotaxis | 146/7305 | 310/18723 | 2.13e-03 | 9.80e-03 | 146 |
GO:00454453 | Oral cavity | OSCC | myoblast differentiation | 46/7305 | 84/18723 | 2.43e-03 | 1.07e-02 | 46 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKIRIN1 | SNV | Missense_Mutation | c.295N>G | p.Gln99Glu | p.Q99E | Q9H9L7 | protein_coding | tolerated(0.1) | probably_damaging(0.99) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AKIRIN1 | SNV | Missense_Mutation | novel | c.469G>A | p.Glu157Lys | p.E157K | Q9H9L7 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
AKIRIN1 | SNV | Missense_Mutation | rs753878747 | c.458G>A | p.Arg153Gln | p.R153Q | Q9H9L7 | protein_coding | tolerated(0.09) | possibly_damaging(0.811) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
AKIRIN1 | SNV | Missense_Mutation | novel | c.567N>A | p.Ser189Arg | p.S189R | Q9H9L7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AKIRIN1 | SNV | Missense_Mutation | rs764613354 | c.225A>C | p.Gln75His | p.Q75H | Q9H9L7 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AKIRIN1 | SNV | Missense_Mutation | novel | c.428N>T | p.Arg143Leu | p.R143L | Q9H9L7 | protein_coding | deleterious(0) | possibly_damaging(0.806) | TCGA-QS-A744-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
AKIRIN1 | SNV | Missense_Mutation | rs781305153 | c.314C>T | p.Ser105Leu | p.S105L | Q9H9L7 | protein_coding | tolerated(0.16) | benign(0.254) | TCGA-FV-A23B-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AKIRIN1 | SNV | Missense_Mutation | novel | c.256C>A | p.Arg86Ser | p.R86S | Q9H9L7 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
AKIRIN1 | SNV | Missense_Mutation | c.180N>T | p.Gln60His | p.Q60H | Q9H9L7 | protein_coding | tolerated(0.09) | benign(0.346) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |