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Gene: ABHD2 |
Gene summary for ABHD2 |
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Gene information | Species | Human | Gene symbol | ABHD2 | Gene ID | 11057 |
Gene name | abhydrolase domain containing 2, acylglycerol lipase | |
Gene Alias | HS1-2 | |
Cytomap | 15q26.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RC89 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11057 | ABHD2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.84e-24 | 1.14e+00 | -0.0811 |
11057 | ABHD2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.96e-07 | 6.15e-01 | -0.1088 |
11057 | ABHD2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.39e-03 | 3.21e-01 | -0.1954 |
11057 | ABHD2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.83e-03 | 1.24e+00 | -0.2602 |
11057 | ABHD2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.81e-07 | 7.30e-01 | -0.059 |
11057 | ABHD2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.12e-02 | 3.81e-01 | 0.0588 |
11057 | ABHD2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.42e-11 | 5.59e-01 | 0.294 |
11057 | ABHD2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.95e-13 | 1.84e+00 | 0.3487 |
11057 | ABHD2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.01e-06 | 7.86e-01 | 0.281 |
11057 | ABHD2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.25e-07 | 7.62e-01 | 0.3859 |
11057 | ABHD2 | A015-C-203 | Human | Colorectum | FAP | 1.70e-12 | -2.96e-01 | -0.1294 |
11057 | ABHD2 | A015-C-204 | Human | Colorectum | FAP | 1.88e-03 | -2.29e-01 | -0.0228 |
11057 | ABHD2 | A002-C-201 | Human | Colorectum | FAP | 5.53e-03 | -1.46e-01 | 0.0324 |
11057 | ABHD2 | A001-C-108 | Human | Colorectum | FAP | 5.12e-04 | 2.63e-02 | -0.0272 |
11057 | ABHD2 | A002-C-205 | Human | Colorectum | FAP | 5.67e-09 | -2.91e-01 | -0.1236 |
11057 | ABHD2 | A015-C-006 | Human | Colorectum | FAP | 3.11e-04 | -2.64e-01 | -0.0994 |
11057 | ABHD2 | A015-C-106 | Human | Colorectum | FAP | 4.13e-06 | -1.73e-01 | -0.0511 |
11057 | ABHD2 | A002-C-114 | Human | Colorectum | FAP | 3.14e-06 | -2.49e-01 | -0.1561 |
11057 | ABHD2 | A015-C-104 | Human | Colorectum | FAP | 1.60e-14 | -2.94e-01 | -0.1899 |
11057 | ABHD2 | A002-C-016 | Human | Colorectum | FAP | 1.38e-08 | -1.45e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485453 | Colorectum | MSI-H | response to steroid hormone | 40/1319 | 339/18723 | 9.37e-04 | 1.64e-02 | 40 |
GO:19016543 | Colorectum | MSI-H | response to ketone | 26/1319 | 194/18723 | 1.17e-03 | 1.92e-02 | 26 |
GO:00463941 | Colorectum | MSI-H | carboxylic acid biosynthetic process | 36/1319 | 314/18723 | 2.68e-03 | 3.48e-02 | 36 |
GO:00160531 | Colorectum | MSI-H | organic acid biosynthetic process | 36/1319 | 316/18723 | 2.98e-03 | 3.78e-02 | 36 |
GO:00434013 | Colorectum | MSI-H | steroid hormone mediated signaling pathway | 19/1319 | 136/18723 | 3.19e-03 | 3.93e-02 | 19 |
GO:00097553 | Colorectum | MSI-H | hormone-mediated signaling pathway | 24/1319 | 190/18723 | 3.88e-03 | 4.51e-02 | 24 |
GO:00713833 | Colorectum | FAP | cellular response to steroid hormone stimulus | 59/2622 | 204/18723 | 2.12e-08 | 2.06e-06 | 59 |
GO:00485454 | Colorectum | FAP | response to steroid hormone | 81/2622 | 339/18723 | 6.22e-07 | 3.08e-05 | 81 |
GO:00434014 | Colorectum | FAP | steroid hormone mediated signaling pathway | 41/2622 | 136/18723 | 8.82e-07 | 4.03e-05 | 41 |
GO:00097554 | Colorectum | FAP | hormone-mediated signaling pathway | 51/2622 | 190/18723 | 2.23e-06 | 8.87e-05 | 51 |
GO:00090623 | Colorectum | FAP | fatty acid catabolic process | 31/2622 | 100/18723 | 9.77e-06 | 2.85e-04 | 31 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00723293 | Colorectum | FAP | monocarboxylic acid catabolic process | 32/2622 | 122/18723 | 2.57e-04 | 3.53e-03 | 32 |
GO:00442422 | Colorectum | FAP | cellular lipid catabolic process | 49/2622 | 214/18723 | 2.87e-04 | 3.77e-03 | 49 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:19016544 | Colorectum | FAP | response to ketone | 45/2622 | 194/18723 | 3.67e-04 | 4.63e-03 | 45 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:00160543 | Colorectum | FAP | organic acid catabolic process | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:00463951 | Colorectum | FAP | carboxylic acid catabolic process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD2 | SNV | Missense_Mutation | rs777916601 | c.134A>G | p.Tyr45Cys | p.Y45C | P08910 | protein_coding | tolerated(0.07) | possibly_damaging(0.599) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ABHD2 | SNV | Missense_Mutation | novel | c.848N>T | p.Pro283Leu | p.P283L | P08910 | protein_coding | tolerated(0.28) | benign(0.033) | TCGA-B6-A0X1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ABHD2 | SNV | Missense_Mutation | c.389N>A | p.Ile130Asn | p.I130N | P08910 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-BH-A0BT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
ABHD2 | SNV | Missense_Mutation | c.482N>G | p.Asn161Ser | p.N161S | P08910 | protein_coding | deleterious(0.03) | possibly_damaging(0.864) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ABHD2 | SNV | Missense_Mutation | c.843N>C | p.Lys281Asn | p.K281N | P08910 | protein_coding | tolerated(0.07) | benign(0.135) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
ABHD2 | SNV | Missense_Mutation | c.751N>G | p.Gln251Glu | p.Q251E | P08910 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ABHD2 | SNV | Missense_Mutation | novel | c.551N>G | p.Glu184Gly | p.E184G | P08910 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
ABHD2 | SNV | Missense_Mutation | c.476T>C | p.Val159Ala | p.V159A | P08910 | protein_coding | deleterious(0.03) | benign(0.142) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ABHD2 | SNV | Missense_Mutation | novel | c.1061C>T | p.Thr354Ile | p.T354I | P08910 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ABHD2 | SNV | Missense_Mutation | rs150079355 | c.697N>A | p.Val233Met | p.V233M | P08910 | protein_coding | tolerated(0.06) | benign(0.21) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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