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Gene: AASDHPPT |
Gene summary for AASDHPPT |
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Gene information | Species | Human | Gene symbol | AASDHPPT | Gene ID | 60496 |
Gene name | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | |
Gene Alias | AASD-PPT | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9NRN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60496 | AASDHPPT | LZE2T | Human | Esophagus | ESCC | 2.94e-02 | 3.79e-01 | 0.082 |
60496 | AASDHPPT | LZE4T | Human | Esophagus | ESCC | 2.48e-23 | 6.08e-01 | 0.0811 |
60496 | AASDHPPT | LZE7T | Human | Esophagus | ESCC | 3.44e-06 | 2.31e-01 | 0.0667 |
60496 | AASDHPPT | LZE8T | Human | Esophagus | ESCC | 1.26e-11 | 3.65e-01 | 0.067 |
60496 | AASDHPPT | LZE20T | Human | Esophagus | ESCC | 3.53e-07 | 1.94e-01 | 0.0662 |
60496 | AASDHPPT | LZE22D1 | Human | Esophagus | HGIN | 4.81e-13 | 4.91e-01 | 0.0595 |
60496 | AASDHPPT | LZE22T | Human | Esophagus | ESCC | 2.57e-17 | 1.63e+00 | 0.068 |
60496 | AASDHPPT | LZE24T | Human | Esophagus | ESCC | 1.48e-31 | 7.24e-01 | 0.0596 |
60496 | AASDHPPT | LZE6T | Human | Esophagus | ESCC | 7.75e-14 | 5.28e-01 | 0.0845 |
60496 | AASDHPPT | P1T-E | Human | Esophagus | ESCC | 7.62e-03 | 1.72e-01 | 0.0875 |
60496 | AASDHPPT | P2T-E | Human | Esophagus | ESCC | 2.61e-32 | 6.15e-01 | 0.1177 |
60496 | AASDHPPT | P4T-E | Human | Esophagus | ESCC | 2.16e-65 | 1.38e+00 | 0.1323 |
60496 | AASDHPPT | P5T-E | Human | Esophagus | ESCC | 1.75e-53 | 1.06e+00 | 0.1327 |
60496 | AASDHPPT | P8T-E | Human | Esophagus | ESCC | 7.54e-21 | 2.63e-01 | 0.0889 |
60496 | AASDHPPT | P9T-E | Human | Esophagus | ESCC | 6.26e-22 | 5.49e-01 | 0.1131 |
60496 | AASDHPPT | P10T-E | Human | Esophagus | ESCC | 1.35e-40 | 6.83e-01 | 0.116 |
60496 | AASDHPPT | P11T-E | Human | Esophagus | ESCC | 2.02e-31 | 9.64e-01 | 0.1426 |
60496 | AASDHPPT | P12T-E | Human | Esophagus | ESCC | 1.73e-50 | 9.92e-01 | 0.1122 |
60496 | AASDHPPT | P15T-E | Human | Esophagus | ESCC | 4.03e-22 | 3.75e-01 | 0.1149 |
60496 | AASDHPPT | P16T-E | Human | Esophagus | ESCC | 2.32e-51 | 8.77e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016077 | Thyroid | PTC | alpha-amino acid biosynthetic process | 33/5968 | 68/18723 | 3.04e-03 | 1.50e-02 | 33 |
GO:00086527 | Thyroid | PTC | cellular amino acid biosynthetic process | 35/5968 | 76/18723 | 6.68e-03 | 2.89e-02 | 35 |
GO:000906711 | Thyroid | ATC | aspartate family amino acid biosynthetic process | 15/6293 | 21/18723 | 4.45e-04 | 2.64e-03 | 15 |
GO:000865212 | Thyroid | ATC | cellular amino acid biosynthetic process | 39/6293 | 76/18723 | 1.07e-03 | 5.63e-03 | 39 |
GO:190160712 | Thyroid | ATC | alpha-amino acid biosynthetic process | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:000657522 | Thyroid | ATC | cellular modified amino acid metabolic process | 82/6293 | 188/18723 | 2.60e-03 | 1.20e-02 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00770 | Liver | Cirrhotic | Pantothenate and CoA biosynthesis | 13/2530 | 21/8465 | 2.32e-03 | 9.90e-03 | 6.10e-03 | 13 |
hsa007701 | Liver | Cirrhotic | Pantothenate and CoA biosynthesis | 13/2530 | 21/8465 | 2.32e-03 | 9.90e-03 | 6.10e-03 | 13 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AASDHPPT | SNV | Missense_Mutation | c.27N>G | p.Cys9Trp | p.C9W | Q9NRN7 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-AR-A1AQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
AASDHPPT | SNV | Missense_Mutation | c.604N>G | p.Leu202Val | p.L202V | Q9NRN7 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
AASDHPPT | SNV | Missense_Mutation | novel | c.94G>A | p.Glu32Lys | p.E32K | Q9NRN7 | protein_coding | deleterious(0.01) | benign(0.328) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AASDHPPT | SNV | Missense_Mutation | c.622N>C | p.Asp208His | p.D208H | Q9NRN7 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
AASDHPPT | deletion | Frame_Shift_Del | novel | c.208delN | p.Leu70Ter | p.L70* | Q9NRN7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
AASDHPPT | deletion | Frame_Shift_Del | novel | c.11_23delNNNNNNNNNNNNN | p.Lys6TrpfsTer56 | p.K6Wfs*56 | Q9NRN7 | protein_coding | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
AASDHPPT | SNV | Missense_Mutation | rs761620246 | c.911N>A | p.Arg304Gln | p.R304Q | Q9NRN7 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.676) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AASDHPPT | SNV | Missense_Mutation | novel | c.94N>A | p.Glu32Lys | p.E32K | Q9NRN7 | protein_coding | deleterious(0.01) | benign(0.328) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AASDHPPT | SNV | Missense_Mutation | c.412C>T | p.Arg138Cys | p.R138C | Q9NRN7 | protein_coding | tolerated(0.05) | possibly_damaging(0.85) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD | |
AASDHPPT | SNV | Missense_Mutation | c.878N>T | p.Asp293Val | p.D293V | Q9NRN7 | protein_coding | deleterious(0.04) | benign(0.067) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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