Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/WASF2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/WASF2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/WASF2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/WASF2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/WASF2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/WASF2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/WASF2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/WASF2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00105919 | Oral cavity | EOLP | regulation of lamellipodium assembly | 14/2218 | 42/18723 | 2.15e-04 | 2.15e-03 | 14 |
GO:00105929 | Oral cavity | EOLP | positive regulation of lamellipodium assembly | 11/2218 | 29/18723 | 2.83e-04 | 2.70e-03 | 11 |
GO:006049122 | Oral cavity | EOLP | regulation of cell projection assembly | 38/2218 | 188/18723 | 6.49e-04 | 5.42e-03 | 38 |
GO:005101726 | Oral cavity | EOLP | actin filament bundle assembly | 33/2218 | 157/18723 | 7.04e-04 | 5.78e-03 | 33 |
GO:003103218 | Oral cavity | EOLP | actomyosin structure organization | 39/2218 | 196/18723 | 7.64e-04 | 6.12e-03 | 39 |
GO:012003222 | Oral cavity | EOLP | regulation of plasma membrane bounded cell projection assembly | 37/2218 | 186/18723 | 1.03e-03 | 7.64e-03 | 37 |
GO:0061572110 | Oral cavity | EOLP | actin filament bundle organization | 33/2218 | 161/18723 | 1.11e-03 | 8.11e-03 | 33 |
GO:003431422 | Oral cavity | EOLP | Arp2/3 complex-mediated actin nucleation | 12/2218 | 39/18723 | 1.34e-03 | 9.33e-03 | 12 |
GO:00511255 | Oral cavity | EOLP | regulation of actin nucleation | 10/2218 | 30/18723 | 1.70e-03 | 1.13e-02 | 10 |
GO:00358551 | Oral cavity | EOLP | megakaryocyte development | 7/2218 | 17/18723 | 2.14e-03 | 1.34e-02 | 7 |
GO:007267321 | Oral cavity | EOLP | lamellipodium morphogenesis | 7/2218 | 17/18723 | 2.14e-03 | 1.34e-02 | 7 |
GO:004501013 | Oral cavity | EOLP | actin nucleation | 14/2218 | 52/18723 | 2.31e-03 | 1.42e-02 | 14 |
GO:0030038110 | Oral cavity | EOLP | contractile actin filament bundle assembly | 23/2218 | 106/18723 | 2.78e-03 | 1.66e-02 | 23 |
GO:0043149110 | Oral cavity | EOLP | stress fiber assembly | 23/2218 | 106/18723 | 2.78e-03 | 1.66e-02 | 23 |
GO:006151512 | Oral cavity | EOLP | myeloid cell development | 17/2218 | 71/18723 | 3.27e-03 | 1.90e-02 | 17 |
GO:005149416 | Oral cavity | EOLP | negative regulation of cytoskeleton organization | 31/2218 | 163/18723 | 5.09e-03 | 2.67e-02 | 31 |
GO:00511273 | Oral cavity | EOLP | positive regulation of actin nucleation | 6/2218 | 15/18723 | 5.31e-03 | 2.76e-02 | 6 |
GO:006034812 | Oral cavity | EOLP | bone development | 37/2218 | 205/18723 | 5.84e-03 | 2.95e-02 | 37 |
GO:003431512 | Oral cavity | EOLP | regulation of Arp2/3 complex-mediated actin nucleation | 7/2218 | 21/18723 | 8.36e-03 | 3.91e-02 | 7 |
GO:0051492110 | Oral cavity | EOLP | regulation of stress fiber assembly | 19/2218 | 91/18723 | 9.46e-03 | 4.29e-02 | 19 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WASF2 | SNV | Missense_Mutation | novel | c.324G>T | p.Gln108His | p.Q108H | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | | c.208G>C | p.Glu70Gln | p.E70Q | Q9Y6W5 | protein_coding | deleterious(0.01) | benign(0.077) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | | c.786N>G | p.Phe262Leu | p.F262L | Q9Y6W5 | protein_coding | tolerated(0.25) | benign(0.173) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASF2 | insertion | In_Frame_Ins | novel | c.703_704insGACTGAGGTGGGAGGATCGCTTGAGCCTGGGAGGTT | p.Ile235delinsArgLeuArgTrpGluAspArgLeuSerLeuGlyGlyPhe | p.I235delinsRLRWEDRLSLGGF | Q9Y6W5 | protein_coding | | | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | novel | c.1423C>T | p.Arg475Cys | p.R475C | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WASF2 | SNV | Missense_Mutation | | c.1438G>A | p.Glu480Lys | p.E480K | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WASF2 | SNV | Missense_Mutation | | c.468N>G | p.Phe156Leu | p.F156L | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | | c.584A>C | p.Lys195Thr | p.K195T | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | novel | c.263A>G | p.Glu88Gly | p.E88G | Q9Y6W5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WASF2 | SNV | Missense_Mutation | novel | c.612N>T | p.Glu204Asp | p.E204D | Q9Y6W5 | protein_coding | deleterious(0.05) | probably_damaging(0.978) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |