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Gene: TCF7L2 |
Gene summary for TCF7L2 |
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Gene information | Species | Human | Gene symbol | TCF7L2 | Gene ID | 6934 |
Gene name | transcription factor 7 like 2 | |
Gene Alias | TCF-4 | |
Cytomap | 10q25.2-q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NQB0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6934 | TCF7L2 | CCI_1 | Human | Cervix | CC | 8.52e-09 | 1.07e+00 | 0.528 |
6934 | TCF7L2 | CCI_2 | Human | Cervix | CC | 2.84e-13 | 1.79e+00 | 0.5249 |
6934 | TCF7L2 | CCI_3 | Human | Cervix | CC | 3.90e-25 | 1.50e+00 | 0.516 |
6934 | TCF7L2 | T1 | Human | Cervix | CC | 2.62e-02 | 2.45e-01 | 0.0918 |
6934 | TCF7L2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.04e-16 | 1.10e+00 | -0.1808 |
6934 | TCF7L2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.23e-28 | 1.18e+00 | -0.0811 |
6934 | TCF7L2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.15e-04 | 6.75e-01 | -0.1088 |
6934 | TCF7L2 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.40e-16 | 1.01e+00 | -0.1954 |
6934 | TCF7L2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.68e-14 | 1.80e+00 | -0.2602 |
6934 | TCF7L2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.47e-27 | 1.77e+00 | -0.2196 |
6934 | TCF7L2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.78e-05 | 5.97e-01 | -0.1207 |
6934 | TCF7L2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.71e-15 | 9.81e-01 | -0.1526 |
6934 | TCF7L2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.78e-11 | 1.02e+00 | -0.1464 |
6934 | TCF7L2 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.71e-08 | 8.85e-01 | -0.1001 |
6934 | TCF7L2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.56e-17 | 1.58e+00 | -0.059 |
6934 | TCF7L2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.16e-05 | 5.40e-01 | -0.1706 |
6934 | TCF7L2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.71e-07 | 6.82e-01 | -0.2061 |
6934 | TCF7L2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.97e-02 | 4.47e-01 | -0.0842 |
6934 | TCF7L2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.13e-15 | 1.20e+00 | 0.3487 |
6934 | TCF7L2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.08e-08 | 6.35e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005116812 | Liver | Cirrhotic | nuclear export | 67/4634 | 154/18723 | 2.57e-07 | 6.41e-06 | 67 |
GO:003428412 | Liver | Cirrhotic | response to monosaccharide | 90/4634 | 225/18723 | 2.87e-07 | 7.01e-06 | 90 |
GO:000974612 | Liver | Cirrhotic | response to hexose | 86/4634 | 219/18723 | 1.30e-06 | 2.59e-05 | 86 |
GO:003209211 | Liver | Cirrhotic | positive regulation of protein binding | 41/4634 | 85/18723 | 2.28e-06 | 4.19e-05 | 41 |
GO:00097497 | Liver | Cirrhotic | response to glucose | 82/4634 | 212/18723 | 4.54e-06 | 7.51e-05 | 82 |
GO:20012377 | Liver | Cirrhotic | negative regulation of extrinsic apoptotic signaling pathway | 44/4634 | 97/18723 | 7.61e-06 | 1.15e-04 | 44 |
GO:001605511 | Liver | Cirrhotic | Wnt signaling pathway | 150/4634 | 444/18723 | 9.75e-06 | 1.42e-04 | 150 |
GO:019873811 | Liver | Cirrhotic | cell-cell signaling by wnt | 150/4634 | 446/18723 | 1.28e-05 | 1.80e-04 | 150 |
GO:003011111 | Liver | Cirrhotic | regulation of Wnt signaling pathway | 112/4634 | 328/18723 | 7.57e-05 | 8.40e-04 | 112 |
GO:00468246 | Liver | Cirrhotic | positive regulation of nucleocytoplasmic transport | 29/4634 | 62/18723 | 1.34e-04 | 1.31e-03 | 29 |
GO:00066114 | Liver | Cirrhotic | protein export from nucleus | 27/4634 | 57/18723 | 1.74e-04 | 1.63e-03 | 27 |
GO:00468256 | Liver | Cirrhotic | regulation of protein export from nucleus | 17/4634 | 30/18723 | 1.87e-04 | 1.74e-03 | 17 |
GO:006082811 | Liver | Cirrhotic | regulation of canonical Wnt signaling pathway | 86/4634 | 253/18723 | 5.70e-04 | 4.46e-03 | 86 |
GO:004259312 | Liver | Cirrhotic | glucose homeostasis | 86/4634 | 258/18723 | 1.12e-03 | 7.73e-03 | 86 |
GO:003350012 | Liver | Cirrhotic | carbohydrate homeostasis | 86/4634 | 259/18723 | 1.28e-03 | 8.61e-03 | 86 |
GO:004244511 | Liver | Cirrhotic | hormone metabolic process | 73/4634 | 218/18723 | 2.22e-03 | 1.36e-02 | 73 |
GO:006007011 | Liver | Cirrhotic | canonical Wnt signaling pathway | 97/4634 | 303/18723 | 2.42e-03 | 1.46e-02 | 97 |
GO:19040191 | Liver | Cirrhotic | epithelial cell apoptotic process | 44/4634 | 121/18723 | 2.86e-03 | 1.65e-02 | 44 |
GO:1904035 | Liver | Cirrhotic | regulation of epithelial cell apoptotic process | 35/4634 | 96/18723 | 6.94e-03 | 3.38e-02 | 35 |
GO:00454442 | Liver | Cirrhotic | fat cell differentiation | 73/4634 | 229/18723 | 8.57e-03 | 3.97e-02 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0516720 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0521010 | Cervix | CC | Colorectal cancer | 27/1267 | 86/8465 | 8.60e-05 | 5.57e-04 | 3.30e-04 | 27 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0521310 | Cervix | CC | Endometrial cancer | 18/1267 | 58/8465 | 1.46e-03 | 6.30e-03 | 3.73e-03 | 18 |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa05224 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05167110 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0521015 | Cervix | CC | Colorectal cancer | 27/1267 | 86/8465 | 8.60e-05 | 5.57e-04 | 3.30e-04 | 27 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0521512 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0521313 | Cervix | CC | Endometrial cancer | 18/1267 | 58/8465 | 1.46e-03 | 6.30e-03 | 3.73e-03 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF7L2 | SNV | Missense_Mutation | c.413C>T | p.Ser138Phe | p.S138F | Q9NQB0 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TCF7L2 | SNV | Missense_Mutation | novel | c.899N>T | p.Pro300Leu | p.P300L | Q9NQB0 | protein_coding | tolerated(0.19) | benign(0.425) | TCGA-AC-A6NO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCF7L2 | SNV | Missense_Mutation | c.1255G>A | p.Ala419Thr | p.A419T | Q9NQB0 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TCF7L2 | SNV | Missense_Mutation | c.931N>T | p.His311Tyr | p.H311Y | Q9NQB0 | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-C8-A1HI-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TCF7L2 | SNV | Missense_Mutation | c.614C>T | p.Thr205Met | p.T205M | Q9NQB0 | protein_coding | tolerated(0.12) | possibly_damaging(0.687) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TCF7L2 | SNV | Missense_Mutation | c.166C>G | p.Gln56Glu | p.Q56E | Q9NQB0 | protein_coding | tolerated(0.56) | possibly_damaging(0.756) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TCF7L2 | SNV | Missense_Mutation | novel | c.1079A>G | p.Tyr360Cys | p.Y360C | Q9NQB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TCF7L2 | insertion | In_Frame_Ins | novel | c.535_536insCAC | p.Pro180dup | p.P180dup | Q9NQB0 | protein_coding | TCGA-C5-A7X3-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | ||
TCF7L2 | SNV | Missense_Mutation | c.1258C>T | p.Arg420Trp | p.R420W | Q9NQB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AATA-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | |
TCF7L2 | SNV | Missense_Mutation | c.1411N>T | p.Arg471Cys | p.R471C | Q9NQB0 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | sulfonamides, urea derivatives | 21114608,17519421 | ||
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | tacrolimus | TACROLIMUS | 23041303,21857094 | |
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | Dipeptidyl peptidase 4 (DPP-4) inhibitors | 27166975 | ||
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | ||
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | cyclosporine | CYCLOSPORINE | 23041303,21857094 | |
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | repaglinide | REPAGLINIDE | 20054294 | |
6934 | TCF7L2 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | sirolimus | SIROLIMUS | 23041303,21857094 |
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