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Gene: SNW1 |
Gene summary for SNW1 |
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Gene information | Species | Human | Gene symbol | SNW1 | Gene ID | 22938 |
Gene name | SNW domain containing 1 | |
Gene Alias | Bx42 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | G3V3A4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22938 | SNW1 | LZE2T | Human | Esophagus | ESCC | 2.86e-05 | 3.95e-01 | 0.082 |
22938 | SNW1 | LZE4T | Human | Esophagus | ESCC | 3.11e-12 | 6.30e-01 | 0.0811 |
22938 | SNW1 | LZE7T | Human | Esophagus | ESCC | 4.60e-06 | 3.07e-01 | 0.0667 |
22938 | SNW1 | LZE8T | Human | Esophagus | ESCC | 3.68e-04 | 1.77e-01 | 0.067 |
22938 | SNW1 | LZE20T | Human | Esophagus | ESCC | 2.07e-12 | 4.24e-01 | 0.0662 |
22938 | SNW1 | LZE22D1 | Human | Esophagus | HGIN | 1.55e-02 | 3.78e-01 | 0.0595 |
22938 | SNW1 | LZE22T | Human | Esophagus | ESCC | 4.82e-05 | 1.08e+00 | 0.068 |
22938 | SNW1 | LZE24T | Human | Esophagus | ESCC | 4.99e-19 | 6.58e-01 | 0.0596 |
22938 | SNW1 | LZE21T | Human | Esophagus | ESCC | 4.02e-05 | 4.86e-01 | 0.0655 |
22938 | SNW1 | LZE6T | Human | Esophagus | ESCC | 3.23e-07 | 2.21e-01 | 0.0845 |
22938 | SNW1 | P1T-E | Human | Esophagus | ESCC | 1.93e-13 | 5.82e-01 | 0.0875 |
22938 | SNW1 | P2T-E | Human | Esophagus | ESCC | 7.88e-32 | 6.62e-01 | 0.1177 |
22938 | SNW1 | P4T-E | Human | Esophagus | ESCC | 3.19e-34 | 7.80e-01 | 0.1323 |
22938 | SNW1 | P5T-E | Human | Esophagus | ESCC | 1.32e-17 | 5.06e-01 | 0.1327 |
22938 | SNW1 | P8T-E | Human | Esophagus | ESCC | 1.24e-33 | 7.06e-01 | 0.0889 |
22938 | SNW1 | P9T-E | Human | Esophagus | ESCC | 3.27e-16 | 4.50e-01 | 0.1131 |
22938 | SNW1 | P10T-E | Human | Esophagus | ESCC | 6.85e-58 | 1.08e+00 | 0.116 |
22938 | SNW1 | P11T-E | Human | Esophagus | ESCC | 1.27e-20 | 9.36e-01 | 0.1426 |
22938 | SNW1 | P12T-E | Human | Esophagus | ESCC | 5.75e-40 | 9.16e-01 | 0.1122 |
22938 | SNW1 | P15T-E | Human | Esophagus | ESCC | 3.03e-56 | 1.38e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:004348435 | Thyroid | ATC | regulation of RNA splicing | 100/6293 | 148/18723 | 2.75e-17 | 2.72e-15 | 100 |
GO:007233135 | Thyroid | ATC | signal transduction by p53 class mediator | 102/6293 | 163/18723 | 3.16e-14 | 1.75e-12 | 102 |
GO:004802434 | Thyroid | ATC | regulation of mRNA splicing, via spliceosome | 70/6293 | 101/18723 | 2.29e-13 | 1.09e-11 | 70 |
GO:007155925 | Thyroid | ATC | response to transforming growth factor beta | 142/6293 | 256/18723 | 4.30e-13 | 1.94e-11 | 142 |
GO:001820516 | Thyroid | ATC | peptidyl-lysine modification | 193/6293 | 376/18723 | 6.92e-13 | 3.06e-11 | 193 |
GO:007156026 | Thyroid | ATC | cellular response to transforming growth factor beta stimulus | 137/6293 | 250/18723 | 3.69e-12 | 1.49e-10 | 137 |
GO:001908023 | Thyroid | ATC | viral gene expression | 64/6293 | 94/18723 | 8.44e-12 | 3.16e-10 | 64 |
GO:004440334 | Thyroid | ATC | biological process involved in symbiotic interaction | 153/6293 | 290/18723 | 1.12e-11 | 4.12e-10 | 153 |
GO:0071496210 | Thyroid | ATC | cellular response to external stimulus | 165/6293 | 320/18723 | 2.01e-11 | 7.23e-10 | 165 |
GO:000717924 | Thyroid | ATC | transforming growth factor beta receptor signaling pathway | 112/6293 | 198/18723 | 2.42e-11 | 8.44e-10 | 112 |
GO:190331324 | Thyroid | ATC | positive regulation of mRNA metabolic process | 75/6293 | 118/18723 | 2.57e-11 | 8.84e-10 | 75 |
GO:0030522112 | Thyroid | ATC | intracellular receptor signaling pathway | 134/6293 | 265/18723 | 7.58e-09 | 1.63e-07 | 134 |
GO:003105616 | Thyroid | ATC | regulation of histone modification | 85/6293 | 152/18723 | 1.23e-08 | 2.55e-07 | 85 |
GO:000717823 | Thyroid | ATC | transmembrane receptor protein serine/threonine kinase signaling pathway | 170/6293 | 355/18723 | 1.40e-08 | 2.87e-07 | 170 |
GO:003166927 | Thyroid | ATC | cellular response to nutrient levels | 112/6293 | 215/18723 | 1.57e-08 | 3.20e-07 | 112 |
GO:001701522 | Thyroid | ATC | regulation of transforming growth factor beta receptor signaling pathway | 74/6293 | 128/18723 | 1.58e-08 | 3.20e-07 | 74 |
GO:003166827 | Thyroid | ATC | cellular response to extracellular stimulus | 125/6293 | 246/18723 | 1.65e-08 | 3.31e-07 | 125 |
GO:190384422 | Thyroid | ATC | regulation of cellular response to transforming growth factor beta stimulus | 75/6293 | 131/18723 | 2.26e-08 | 4.39e-07 | 75 |
GO:001072022 | Thyroid | ATC | positive regulation of cell development | 146/6293 | 298/18723 | 2.36e-08 | 4.56e-07 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0516930 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa05169114 | Esophagus | HGIN | Epstein-Barr virus infection | 55/1383 | 202/8465 | 5.13e-05 | 6.19e-04 | 4.92e-04 | 55 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0516914 | Liver | Cirrhotic | Epstein-Barr virus infection | 80/2530 | 202/8465 | 1.80e-03 | 8.33e-03 | 5.13e-03 | 80 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0516915 | Liver | Cirrhotic | Epstein-Barr virus infection | 80/2530 | 202/8465 | 1.80e-03 | 8.33e-03 | 5.13e-03 | 80 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNW1 | SNV | Missense_Mutation | c.883N>T | p.Asp295Tyr | p.D295Y | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
SNW1 | SNV | Missense_Mutation | novel | c.422N>T | p.Lys141Ile | p.K141I | protein_coding | tolerated(0.1) | benign(0.026) | TCGA-S3-AA15-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
SNW1 | SNV | Missense_Mutation | c.1070N>T | p.His357Leu | p.H357L | protein_coding | tolerated(0.38) | benign(0.007) | TCGA-EA-A78R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNW1 | SNV | Missense_Mutation | c.228N>C | p.Met76Ile | p.M76I | protein_coding | deleterious(0.01) | possibly_damaging(0.903) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
SNW1 | SNV | Missense_Mutation | c.401G>T | p.Arg134Met | p.R134M | protein_coding | deleterious(0.04) | benign(0.138) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SNW1 | SNV | Missense_Mutation | c.1052N>C | p.Glu351Ala | p.E351A | protein_coding | tolerated(0.12) | benign(0.272) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SNW1 | SNV | Missense_Mutation | c.479C>T | p.Ala160Val | p.A160V | protein_coding | deleterious(0.03) | benign(0.26) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SNW1 | SNV | Missense_Mutation | c.883N>A | p.Asp295Asn | p.D295N | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SNW1 | SNV | Missense_Mutation | c.553N>A | p.Gly185Arg | p.G185R | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SNW1 | SNV | Missense_Mutation | rs759186141 | c.254N>T | p.Ala85Val | p.A85V | protein_coding | tolerated(0.1) | benign(0.089) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22938 | SNW1 | NA | TRANSFORMING GROWTH FACTOR | 15149847 |
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