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Gene: PRDX1 |
Gene summary for PRDX1 |
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Gene information | Species | Human | Gene symbol | PRDX1 | Gene ID | 5052 |
Gene name | peroxiredoxin 1 | |
Gene Alias | MSP23 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q06830 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5052 | PRDX1 | GSM4909281 | Human | Breast | IDC | 9.05e-09 | 3.12e-01 | 0.21 |
5052 | PRDX1 | GSM4909282 | Human | Breast | IDC | 1.60e-27 | 4.41e-01 | -0.0288 |
5052 | PRDX1 | GSM4909285 | Human | Breast | IDC | 1.75e-87 | 7.42e-01 | 0.21 |
5052 | PRDX1 | GSM4909286 | Human | Breast | IDC | 5.12e-03 | 3.07e-02 | 0.1081 |
5052 | PRDX1 | GSM4909287 | Human | Breast | IDC | 4.10e-12 | 3.40e-01 | 0.2057 |
5052 | PRDX1 | GSM4909288 | Human | Breast | IDC | 1.92e-06 | 3.46e-01 | 0.0988 |
5052 | PRDX1 | GSM4909290 | Human | Breast | IDC | 4.92e-05 | 3.47e-01 | 0.2096 |
5052 | PRDX1 | GSM4909293 | Human | Breast | IDC | 3.40e-06 | 2.59e-01 | 0.1581 |
5052 | PRDX1 | GSM4909294 | Human | Breast | IDC | 2.85e-29 | 3.27e-01 | 0.2022 |
5052 | PRDX1 | GSM4909296 | Human | Breast | IDC | 1.30e-23 | 3.76e-01 | 0.1524 |
5052 | PRDX1 | GSM4909297 | Human | Breast | IDC | 7.58e-21 | -1.05e-01 | 0.1517 |
5052 | PRDX1 | GSM4909304 | Human | Breast | IDC | 2.60e-90 | 7.57e-01 | 0.1636 |
5052 | PRDX1 | GSM4909306 | Human | Breast | IDC | 2.46e-07 | 2.80e-01 | 0.1564 |
5052 | PRDX1 | GSM4909308 | Human | Breast | IDC | 7.27e-10 | -1.11e-01 | 0.158 |
5052 | PRDX1 | GSM4909311 | Human | Breast | IDC | 4.87e-44 | -2.04e-01 | 0.1534 |
5052 | PRDX1 | GSM4909312 | Human | Breast | IDC | 3.65e-14 | 1.75e-01 | 0.1552 |
5052 | PRDX1 | GSM4909313 | Human | Breast | IDC | 5.96e-04 | -3.83e-01 | 0.0391 |
5052 | PRDX1 | GSM4909315 | Human | Breast | IDC | 4.70e-60 | 5.96e-01 | 0.21 |
5052 | PRDX1 | GSM4909316 | Human | Breast | IDC | 5.73e-26 | 7.08e-01 | 0.21 |
5052 | PRDX1 | GSM4909319 | Human | Breast | IDC | 6.31e-58 | -7.78e-02 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045454110 | Thyroid | PTC | cell redox homeostasis | 23/5968 | 35/18723 | 4.02e-05 | 3.68e-04 | 23 |
GO:1990748112 | Thyroid | PTC | cellular detoxification | 56/5968 | 116/18723 | 1.63e-04 | 1.26e-03 | 56 |
GO:0097237112 | Thyroid | PTC | cellular response to toxic substance | 59/5968 | 124/18723 | 1.83e-04 | 1.39e-03 | 59 |
GO:0098869111 | Thyroid | PTC | cellular oxidant detoxification | 49/5968 | 101/18723 | 3.52e-04 | 2.41e-03 | 49 |
GO:0070302110 | Thyroid | PTC | regulation of stress-activated protein kinase signaling cascade | 83/5968 | 195/18723 | 1.04e-03 | 6.21e-03 | 83 |
GO:003806113 | Thyroid | PTC | NIK/NF-kappaB signaling | 63/5968 | 143/18723 | 1.45e-03 | 8.12e-03 | 63 |
GO:0032872110 | Thyroid | PTC | regulation of stress-activated MAPK cascade | 81/5968 | 192/18723 | 1.62e-03 | 8.95e-03 | 81 |
GO:190122213 | Thyroid | PTC | regulation of NIK/NF-kappaB signaling | 49/5968 | 112/18723 | 5.42e-03 | 2.49e-02 | 49 |
GO:004274316 | Thyroid | PTC | hydrogen peroxide metabolic process | 28/5968 | 58/18723 | 6.64e-03 | 2.89e-02 | 28 |
GO:0098754110 | Thyroid | PTC | detoxification | 63/5968 | 152/18723 | 7.92e-03 | 3.34e-02 | 63 |
GO:009875426 | Thyroid | goiters | detoxification | 19/497 | 152/18723 | 2.24e-08 | 2.16e-06 | 19 |
GO:009886927 | Thyroid | goiters | cellular oxidant detoxification | 15/497 | 101/18723 | 6.79e-08 | 5.98e-06 | 15 |
GO:199074828 | Thyroid | goiters | cellular detoxification | 16/497 | 116/18723 | 7.23e-08 | 6.23e-06 | 16 |
GO:009723728 | Thyroid | goiters | cellular response to toxic substance | 16/497 | 124/18723 | 1.86e-07 | 1.45e-05 | 16 |
GO:0006979210 | Thyroid | goiters | response to oxidative stress | 32/497 | 446/18723 | 3.87e-07 | 2.67e-05 | 32 |
GO:0000302210 | Thyroid | goiters | response to reactive oxygen species | 20/497 | 222/18723 | 2.09e-06 | 1.09e-04 | 20 |
GO:000963628 | Thyroid | goiters | response to toxic substance | 21/497 | 262/18723 | 7.42e-06 | 3.22e-04 | 21 |
GO:004545423 | Thyroid | goiters | cell redox homeostasis | 7/497 | 35/18723 | 3.14e-05 | 1.15e-03 | 7 |
GO:0062197210 | Thyroid | goiters | cellular response to chemical stress | 22/497 | 337/18723 | 1.05e-04 | 3.29e-03 | 22 |
GO:007259324 | Thyroid | goiters | reactive oxygen species metabolic process | 17/497 | 239/18723 | 2.32e-04 | 6.49e-03 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051465 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa0514612 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa051466 | Endometrium | AEH | Amoebiasis | 29/1197 | 102/8465 | 1.22e-04 | 1.10e-03 | 8.06e-04 | 29 |
hsa0514613 | Endometrium | AEH | Amoebiasis | 29/1197 | 102/8465 | 1.22e-04 | 1.10e-03 | 8.06e-04 | 29 |
hsa0514622 | Endometrium | EEC | Amoebiasis | 28/1237 | 102/8465 | 5.23e-04 | 3.83e-03 | 2.85e-03 | 28 |
hsa0514632 | Endometrium | EEC | Amoebiasis | 28/1237 | 102/8465 | 5.23e-04 | 3.83e-03 | 2.85e-03 | 28 |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041462 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041463 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa051468 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0514615 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0514623 | Oral cavity | EOLP | Amoebiasis | 26/1218 | 102/8465 | 2.09e-03 | 7.03e-03 | 4.15e-03 | 26 |
hsa0514633 | Oral cavity | EOLP | Amoebiasis | 26/1218 | 102/8465 | 2.09e-03 | 7.03e-03 | 4.15e-03 | 26 |
hsa0514641 | Oral cavity | NEOLP | Amoebiasis | 26/1112 | 102/8465 | 5.36e-04 | 3.05e-03 | 1.92e-03 | 26 |
hsa0514651 | Oral cavity | NEOLP | Amoebiasis | 26/1112 | 102/8465 | 5.36e-04 | 3.05e-03 | 1.92e-03 | 26 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRDX1 | SNV | Missense_Mutation | c.28N>T | p.His10Tyr | p.H10Y | Q06830 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PRDX1 | SNV | Missense_Mutation | novel | c.62N>C | p.Met21Thr | p.M21T | Q06830 | protein_coding | deleterious(0) | benign(0.271) | TCGA-C8-A3M8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
PRDX1 | insertion | Frame_Shift_Ins | novel | c.356dupT | p.Leu119PhefsTer4 | p.L119Ffs*4 | Q06830 | protein_coding | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
PRDX1 | SNV | Missense_Mutation | novel | c.55G>A | p.Ala19Thr | p.A19T | Q06830 | protein_coding | deleterious(0.02) | possibly_damaging(0.888) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRDX1 | SNV | Missense_Mutation | rs765714807 | c.552C>G | p.Ile184Met | p.I184M | Q06830 | protein_coding | tolerated(0.24) | benign(0.345) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PRDX1 | SNV | Missense_Mutation | c.187G>A | p.Ala63Thr | p.A63T | Q06830 | protein_coding | tolerated(0.11) | benign(0.094) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRDX1 | SNV | Missense_Mutation | c.580T>C | p.Tyr194His | p.Y194H | Q06830 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PRDX1 | SNV | Missense_Mutation | novel | c.212N>A | p.Cys71Tyr | p.C71Y | Q06830 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRDX1 | SNV | Missense_Mutation | novel | c.34N>A | p.Ala12Thr | p.A12T | Q06830 | protein_coding | deleterious(0) | benign(0.185) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRDX1 | SNV | Missense_Mutation | c.167N>C | p.Ile56Thr | p.I56T | Q06830 | protein_coding | deleterious(0) | possibly_damaging(0.63) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5052 | PRDX1 | ENZYME | ANTIOXIDANT | 9388242 | ||
5052 | PRDX1 | ENZYME | HYDROGEN PEROXIDE | 14765133 |
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