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Gene: PLAU |
Gene summary for PLAU |
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Gene information | Species | Human | Gene symbol | PLAU | Gene ID | 5328 |
Gene name | plasminogen activator, urokinase | |
Gene Alias | ATF | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | P00749 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5328 | PLAU | CA_HPV_2 | Human | Cervix | CC | 3.31e-04 | 3.27e-01 | 0.0391 |
5328 | PLAU | Tumor | Human | Cervix | CC | 6.94e-09 | 3.60e-01 | 0.1241 |
5328 | PLAU | sample1 | Human | Cervix | CC | 4.14e-02 | 3.83e-01 | 0.0959 |
5328 | PLAU | sample3 | Human | Cervix | CC | 3.87e-25 | 6.78e-01 | 0.1387 |
5328 | PLAU | T1 | Human | Cervix | CC | 4.46e-04 | 3.39e-01 | 0.0918 |
5328 | PLAU | T3 | Human | Cervix | CC | 1.45e-23 | 6.42e-01 | 0.1389 |
5328 | PLAU | LZE4T | Human | Esophagus | ESCC | 8.88e-10 | 6.09e-01 | 0.0811 |
5328 | PLAU | LZE8T | Human | Esophagus | ESCC | 7.28e-17 | 1.34e+00 | 0.067 |
5328 | PLAU | LZE20T | Human | Esophagus | ESCC | 4.67e-04 | 4.20e-01 | 0.0662 |
5328 | PLAU | LZE22T | Human | Esophagus | ESCC | 2.81e-04 | 1.06e+00 | 0.068 |
5328 | PLAU | LZE24T | Human | Esophagus | ESCC | 1.83e-07 | 1.77e+00 | 0.0596 |
5328 | PLAU | LZE21T | Human | Esophagus | ESCC | 9.81e-09 | 7.97e-01 | 0.0655 |
5328 | PLAU | P1T-E | Human | Esophagus | ESCC | 9.89e-06 | 1.90e+00 | 0.0875 |
5328 | PLAU | P2T-E | Human | Esophagus | ESCC | 6.06e-38 | 1.54e+00 | 0.1177 |
5328 | PLAU | P4T-E | Human | Esophagus | ESCC | 5.05e-52 | 2.16e+00 | 0.1323 |
5328 | PLAU | P5T-E | Human | Esophagus | ESCC | 1.80e-29 | 1.03e+00 | 0.1327 |
5328 | PLAU | P9T-E | Human | Esophagus | ESCC | 6.08e-10 | 4.89e-01 | 0.1131 |
5328 | PLAU | P11T-E | Human | Esophagus | ESCC | 1.17e-24 | 3.12e+00 | 0.1426 |
5328 | PLAU | P12T-E | Human | Esophagus | ESCC | 3.26e-19 | 6.73e-01 | 0.1122 |
5328 | PLAU | P15T-E | Human | Esophagus | ESCC | 7.98e-22 | 7.97e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001648512 | Prostate | Tumor | protein processing | 63/3246 | 225/18723 | 4.40e-05 | 4.98e-04 | 63 |
GO:001082116 | Prostate | Tumor | regulation of mitochondrion organization | 44/3246 | 144/18723 | 6.75e-05 | 7.21e-04 | 44 |
GO:001095116 | Prostate | Tumor | negative regulation of endopeptidase activity | 68/3246 | 252/18723 | 7.91e-05 | 8.19e-04 | 68 |
GO:001046617 | Prostate | Tumor | negative regulation of peptidase activity | 70/3246 | 262/18723 | 8.76e-05 | 8.66e-04 | 70 |
GO:006104115 | Prostate | Tumor | regulation of wound healing | 41/3246 | 134/18723 | 1.14e-04 | 1.08e-03 | 41 |
GO:190303417 | Prostate | Tumor | regulation of response to wounding | 48/3246 | 167/18723 | 1.72e-04 | 1.53e-03 | 48 |
GO:000183615 | Prostate | Tumor | release of cytochrome c from mitochondria | 22/3246 | 59/18723 | 2.05e-04 | 1.79e-03 | 22 |
GO:003812714 | Prostate | Tumor | ERBB signaling pathway | 37/3246 | 121/18723 | 2.42e-04 | 2.05e-03 | 37 |
GO:001082213 | Prostate | Tumor | positive regulation of mitochondrion organization | 25/3246 | 74/18723 | 4.62e-04 | 3.47e-03 | 25 |
GO:005087818 | Prostate | Tumor | regulation of body fluid levels | 91/3246 | 379/18723 | 5.37e-04 | 3.91e-03 | 91 |
GO:003362712 | Prostate | Tumor | cell adhesion mediated by integrin | 24/3246 | 72/18723 | 7.41e-04 | 5.13e-03 | 24 |
GO:002240916 | Prostate | Tumor | positive regulation of cell-cell adhesion | 70/3246 | 284/18723 | 1.06e-03 | 6.87e-03 | 70 |
GO:000717314 | Prostate | Tumor | epidermal growth factor receptor signaling pathway | 32/3246 | 108/18723 | 1.12e-03 | 7.14e-03 | 32 |
GO:003411011 | Prostate | Tumor | regulation of homotypic cell-cell adhesion | 13/3246 | 33/18723 | 2.26e-03 | 1.28e-02 | 13 |
GO:00341121 | Prostate | Tumor | positive regulation of homotypic cell-cell adhesion | 7/3246 | 13/18723 | 3.02e-03 | 1.61e-02 | 7 |
GO:00148121 | Prostate | Tumor | muscle cell migration | 31/3246 | 110/18723 | 3.15e-03 | 1.65e-02 | 31 |
GO:000759614 | Prostate | Tumor | blood coagulation | 53/3246 | 217/18723 | 4.89e-03 | 2.39e-02 | 53 |
GO:005081714 | Prostate | Tumor | coagulation | 54/3246 | 222/18723 | 4.95e-03 | 2.42e-02 | 54 |
GO:001490912 | Prostate | Tumor | smooth muscle cell migration | 27/3246 | 97/18723 | 6.70e-03 | 3.06e-02 | 27 |
GO:000759914 | Prostate | Tumor | hemostasis | 53/3246 | 222/18723 | 7.87e-03 | 3.50e-02 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0521512 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0521516 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa040645 | Esophagus | ESCC | NF-kappa B signaling pathway | 67/4205 | 104/8465 | 1.62e-03 | 4.89e-03 | 2.50e-03 | 67 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0521517 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0406412 | Esophagus | ESCC | NF-kappa B signaling pathway | 67/4205 | 104/8465 | 1.62e-03 | 4.89e-03 | 2.50e-03 | 67 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520526 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa0521510 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
hsa040644 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa05205111 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa0521515 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
hsa0406411 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0520527 | Oral cavity | LP | Proteoglycans in cancer | 77/2418 | 205/8465 | 3.01e-03 | 1.29e-02 | 8.35e-03 | 77 |
hsa0520536 | Oral cavity | LP | Proteoglycans in cancer | 77/2418 | 205/8465 | 3.01e-03 | 1.29e-02 | 8.35e-03 | 77 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAU | SNV | Missense_Mutation | rs754958267 | c.841N>T | p.Ile281Phe | p.I281F | P00749 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-LD-A9QF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
PLAU | SNV | Missense_Mutation | c.212N>T | p.Tyr71Phe | p.Y71F | P00749 | protein_coding | tolerated(0.06) | benign(0.073) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
PLAU | SNV | Missense_Mutation | c.1091A>G | p.Asp364Gly | p.D364G | P00749 | protein_coding | tolerated(0.08) | benign(0.359) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PLAU | SNV | Missense_Mutation | c.446N>G | p.His149Arg | p.H149R | P00749 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
PLAU | SNV | Missense_Mutation | c.1187N>T | p.Trp396Leu | p.W396L | P00749 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLAU | SNV | Missense_Mutation | novel | c.28C>A | p.Leu10Ile | p.L10I | P00749 | protein_coding | tolerated(0.08) | benign(0.15) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLAU | SNV | Missense_Mutation | rs370557565 | c.86N>T | p.Ser29Leu | p.S29L | P00749 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
PLAU | SNV | Missense_Mutation | novel | c.497N>G | p.Phe166Cys | p.F166C | P00749 | protein_coding | deleterious(0.05) | probably_damaging(0.995) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAU | SNV | Missense_Mutation | novel | c.181N>T | p.His61Tyr | p.H61Y | P00749 | protein_coding | tolerated(0.07) | benign(0.069) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLAU | SNV | Missense_Mutation | c.1042N>T | p.Pro348Ser | p.P348S | P00749 | protein_coding | deleterious(0.03) | probably_damaging(0.956) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | RETINOL | RETINOL | 1576255 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | ALENDRONATE | ALENDRONIC ACID | 11984068 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | RAZOXANE | RAZOXANE | 9378540 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | MRX-801 | |||
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | BCNU | CARMUSTINE | 9219734 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | DIFFERENTIATION INDUCER | 8595156 | ||
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | CORTISOL | HYDROCORTISONE | 2115769 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | G-CSF | FILGRASTIM | 16331631 | |
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | ANTIOXIDANT | 9573532 | ||
5328 | PLAU | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | CALCITRIOL | CALCITRIOL | 3139763 |
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