![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PDK4 |
Gene summary for PDK4 |
![]() |
Gene information | Species | Human | Gene symbol | PDK4 | Gene ID | 5166 |
Gene name | pyruvate dehydrogenase kinase 4 | |
Gene Alias | PDK4 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | A4D1H4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5166 | PDK4 | GSM4909280 | Human | Breast | Precancer | 1.02e-04 | 5.73e-01 | 0.0305 |
5166 | PDK4 | GSM4909281 | Human | Breast | IDC | 5.37e-03 | -1.67e-01 | 0.21 |
5166 | PDK4 | GSM4909282 | Human | Breast | IDC | 3.66e-05 | -1.72e-01 | -0.0288 |
5166 | PDK4 | GSM4909285 | Human | Breast | IDC | 3.66e-05 | -1.72e-01 | 0.21 |
5166 | PDK4 | GSM4909286 | Human | Breast | IDC | 1.72e-05 | -1.74e-01 | 0.1081 |
5166 | PDK4 | GSM4909290 | Human | Breast | IDC | 5.07e-03 | -1.74e-01 | 0.2096 |
5166 | PDK4 | GSM4909296 | Human | Breast | IDC | 1.64e-03 | -1.56e-01 | 0.1524 |
5166 | PDK4 | GSM4909311 | Human | Breast | IDC | 1.15e-04 | -1.24e-01 | 0.1534 |
5166 | PDK4 | GSM4909315 | Human | Breast | IDC | 1.72e-05 | -1.74e-01 | 0.21 |
5166 | PDK4 | GSM4909319 | Human | Breast | IDC | 1.47e-08 | 1.42e-02 | 0.1563 |
5166 | PDK4 | brca2 | Human | Breast | Precancer | 1.09e-03 | 2.44e-01 | -0.024 |
5166 | PDK4 | NCCBC5 | Human | Breast | DCIS | 2.81e-03 | -1.74e-01 | 0.2046 |
5166 | PDK4 | DCIS2 | Human | Breast | DCIS | 1.66e-30 | 5.89e-01 | 0.0085 |
5166 | PDK4 | NAFLD1 | Human | Liver | NAFLD | 2.30e-02 | 4.03e-01 | -0.04 |
5166 | PDK4 | S43 | Human | Liver | Cirrhotic | 9.81e-08 | 1.57e-01 | -0.0187 |
5166 | PDK4 | S44 | Human | Liver | HCC | 3.51e-23 | 1.73e+00 | -0.0083 |
5166 | PDK4 | HCC1_Meng | Human | Liver | HCC | 4.47e-04 | -1.99e-01 | 0.0246 |
5166 | PDK4 | HCC2_Meng | Human | Liver | HCC | 4.09e-14 | 2.06e-03 | 0.0107 |
5166 | PDK4 | HCC1 | Human | Liver | HCC | 9.06e-05 | 2.46e+00 | 0.5336 |
5166 | PDK4 | HCC2 | Human | Liver | HCC | 1.26e-04 | 2.96e+00 | 0.5341 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007252121 | Stomach | CSG | purine-containing compound metabolic process | 48/1034 | 416/18723 | 1.11e-06 | 5.64e-05 | 48 |
GO:001969321 | Stomach | CSG | ribose phosphate metabolic process | 46/1034 | 396/18723 | 1.54e-06 | 7.39e-05 | 46 |
GO:004639021 | Stomach | CSG | ribose phosphate biosynthetic process | 28/1034 | 190/18723 | 1.98e-06 | 9.02e-05 | 28 |
GO:000616421 | Stomach | CSG | purine nucleotide biosynthetic process | 28/1034 | 191/18723 | 2.20e-06 | 9.85e-05 | 28 |
GO:007259321 | Stomach | CSG | reactive oxygen species metabolic process | 32/1034 | 239/18723 | 3.18e-06 | 1.37e-04 | 32 |
GO:000911721 | Stomach | CSG | nucleotide metabolic process | 52/1034 | 489/18723 | 4.59e-06 | 1.84e-04 | 52 |
GO:007252221 | Stomach | CSG | purine-containing compound biosynthetic process | 28/1034 | 200/18723 | 5.46e-06 | 2.08e-04 | 28 |
GO:000675321 | Stomach | CSG | nucleoside phosphate metabolic process | 52/1034 | 497/18723 | 7.29e-06 | 2.62e-04 | 52 |
GO:000663121 | Stomach | CSG | fatty acid metabolic process | 43/1034 | 390/18723 | 1.25e-05 | 4.20e-04 | 43 |
GO:003166721 | Stomach | CSG | response to nutrient levels | 49/1034 | 474/18723 | 1.83e-05 | 5.57e-04 | 49 |
GO:000916521 | Stomach | CSG | nucleotide biosynthetic process | 31/1034 | 254/18723 | 2.93e-05 | 8.26e-04 | 31 |
GO:190129321 | Stomach | CSG | nucleoside phosphate biosynthetic process | 31/1034 | 256/18723 | 3.42e-05 | 9.31e-04 | 31 |
GO:004259321 | Stomach | CSG | glucose homeostasis | 30/1034 | 258/18723 | 9.62e-05 | 2.18e-03 | 30 |
GO:003350021 | Stomach | CSG | carbohydrate homeostasis | 30/1034 | 259/18723 | 1.03e-04 | 2.28e-03 | 30 |
GO:007149621 | Stomach | CSG | cellular response to external stimulus | 32/1034 | 320/18723 | 8.75e-04 | 1.17e-02 | 32 |
GO:00713982 | Stomach | CSG | cellular response to fatty acid | 8/1034 | 38/18723 | 9.35e-04 | 1.22e-02 | 8 |
GO:00066332 | Stomach | CSG | fatty acid biosynthetic process | 19/1034 | 163/18723 | 1.68e-03 | 1.85e-02 | 19 |
GO:00463942 | Stomach | CSG | carboxylic acid biosynthetic process | 30/1034 | 314/18723 | 2.52e-03 | 2.46e-02 | 30 |
GO:00705422 | Stomach | CSG | response to fatty acid | 10/1034 | 64/18723 | 2.52e-03 | 2.46e-02 | 10 |
GO:004343421 | Stomach | CSG | response to peptide hormone | 37/1034 | 414/18723 | 2.75e-03 | 2.62e-02 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0541523 | Breast | IDC | Diabetic cardiomyopathy | 67/867 | 203/8465 | 3.17e-19 | 8.59e-18 | 6.43e-18 | 67 |
hsa0541533 | Breast | IDC | Diabetic cardiomyopathy | 67/867 | 203/8465 | 3.17e-19 | 8.59e-18 | 6.43e-18 | 67 |
hsa0541543 | Breast | DCIS | Diabetic cardiomyopathy | 65/846 | 203/8465 | 1.81e-18 | 4.87e-17 | 3.59e-17 | 65 |
hsa0541553 | Breast | DCIS | Diabetic cardiomyopathy | 65/846 | 203/8465 | 1.81e-18 | 4.87e-17 | 3.59e-17 | 65 |
hsa0541514 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541515 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415113 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa0541527 | Prostate | BPH | Diabetic cardiomyopathy | 102/1718 | 203/8465 | 6.06e-22 | 2.00e-20 | 1.24e-20 | 102 |
hsa05415112 | Prostate | BPH | Diabetic cardiomyopathy | 102/1718 | 203/8465 | 6.06e-22 | 2.00e-20 | 1.24e-20 | 102 |
hsa0541528 | Prostate | Tumor | Diabetic cardiomyopathy | 103/1791 | 203/8465 | 4.04e-21 | 1.22e-19 | 7.54e-20 | 103 |
hsa0541536 | Prostate | Tumor | Diabetic cardiomyopathy | 103/1791 | 203/8465 | 4.04e-21 | 1.22e-19 | 7.54e-20 | 103 |
hsa0541512 | Stomach | GC | Diabetic cardiomyopathy | 56/708 | 203/8465 | 2.48e-16 | 1.14e-14 | 8.00e-15 | 56 |
hsa0541513 | Stomach | GC | Diabetic cardiomyopathy | 56/708 | 203/8465 | 2.48e-16 | 1.14e-14 | 8.00e-15 | 56 |
hsa0541521 | Stomach | CAG with IM | Diabetic cardiomyopathy | 56/640 | 203/8465 | 2.41e-18 | 1.10e-16 | 7.69e-17 | 56 |
hsa0541531 | Stomach | CAG with IM | Diabetic cardiomyopathy | 56/640 | 203/8465 | 2.41e-18 | 1.10e-16 | 7.69e-17 | 56 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDK4 | SNV | Missense_Mutation | c.1034A>T | p.Gln345Leu | p.Q345L | Q16654 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDK4 | SNV | Missense_Mutation | c.905N>G | p.Ile302Ser | p.I302S | Q16654 | protein_coding | tolerated(0.07) | benign(0.076) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |
PDK4 | SNV | Missense_Mutation | c.884G>A | p.Gly295Glu | p.G295E | Q16654 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDK4 | SNV | Missense_Mutation | rs778644301 | c.477N>T | p.Leu159Phe | p.L159F | Q16654 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD |
PDK4 | deletion | Frame_Shift_Del | novel | c.517delN | p.Met173Ter | p.M173* | Q16654 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PDK4 | SNV | Missense_Mutation | novel | c.875N>T | p.Ser292Leu | p.S292L | Q16654 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDK4 | SNV | Missense_Mutation | c.997N>A | p.Gly333Ser | p.G333S | Q16654 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDK4 | SNV | Missense_Mutation | rs142890516 | c.768N>G | p.Phe256Leu | p.F256L | Q16654 | protein_coding | tolerated(0.21) | benign(0.229) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDK4 | SNV | Missense_Mutation | novel | c.680N>G | p.Leu227Arg | p.L227R | Q16654 | protein_coding | deleterious(0) | possibly_damaging(0.747) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDK4 | SNV | Missense_Mutation | novel | c.565A>C | p.Ser189Arg | p.S189R | Q16654 | protein_coding | tolerated(0.94) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5166 | PDK4 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | CPI-613 | |||
5166 | PDK4 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 328083452 |
Page: 1 |