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Gene: PAWR |
Gene summary for PAWR |
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Gene information | Species | Human | Gene symbol | PAWR | Gene ID | 5074 |
Gene name | pro-apoptotic WT1 regulator | |
Gene Alias | PAR4 | |
Cytomap | 12q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96IZ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5074 | PAWR | CA_HPV_1 | Human | Cervix | CC | 1.54e-08 | -2.40e-01 | 0.0264 |
5074 | PAWR | CA_HPV_3 | Human | Cervix | CC | 5.69e-09 | 2.93e-01 | 0.0414 |
5074 | PAWR | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 7.70e-03 | -1.98e-01 | 0.0116 |
5074 | PAWR | CCI_1 | Human | Cervix | CC | 1.10e-05 | 9.38e-01 | 0.528 |
5074 | PAWR | CCI_2 | Human | Cervix | CC | 5.44e-04 | 1.37e+00 | 0.5249 |
5074 | PAWR | CCI_3 | Human | Cervix | CC | 1.82e-06 | 7.29e-01 | 0.516 |
5074 | PAWR | sample3 | Human | Cervix | CC | 5.79e-09 | 3.31e-01 | 0.1387 |
5074 | PAWR | T3 | Human | Cervix | CC | 5.20e-16 | 3.42e-01 | 0.1389 |
5074 | PAWR | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.54e-06 | -3.11e-01 | 0.0155 |
5074 | PAWR | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.31e-09 | 6.36e-01 | -0.0811 |
5074 | PAWR | HTA11_347_2000001011 | Human | Colorectum | AD | 1.28e-24 | 8.29e-01 | -0.1954 |
5074 | PAWR | HTA11_411_2000001011 | Human | Colorectum | SER | 8.26e-04 | 4.79e-01 | -0.2602 |
5074 | PAWR | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.05e-02 | -4.12e-01 | -0.00410000000000005 |
5074 | PAWR | HTA11_9408_2000001011 | Human | Colorectum | AD | 8.55e-04 | -6.26e-01 | 0.0451 |
5074 | PAWR | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.20e-04 | -4.93e-01 | 0.0528 |
5074 | PAWR | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.22e-02 | 6.29e-01 | 0.3487 |
5074 | PAWR | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.60e-03 | 4.08e-01 | 0.281 |
5074 | PAWR | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.58e-02 | -5.49e-01 | 0.2585 |
5074 | PAWR | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.52e-15 | -6.04e-01 | 0.3005 |
5074 | PAWR | F007 | Human | Colorectum | FAP | 8.94e-08 | -4.51e-01 | 0.1176 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00104212 | Thyroid | PTC | hydrogen peroxide-mediated programmed cell death | 9/5968 | 14/18723 | 1.27e-02 | 4.92e-02 | 9 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
GO:006219734 | Thyroid | ATC | cellular response to chemical stress | 188/6293 | 337/18723 | 3.16e-17 | 3.07e-15 | 188 |
GO:0007015210 | Thyroid | ATC | actin filament organization | 227/6293 | 442/18723 | 5.96e-15 | 3.85e-13 | 227 |
GO:003459934 | Thyroid | ATC | cellular response to oxidative stress | 158/6293 | 288/18723 | 7.35e-14 | 3.94e-12 | 158 |
GO:000030234 | Thyroid | ATC | response to reactive oxygen species | 128/6293 | 222/18723 | 1.38e-13 | 7.00e-12 | 128 |
GO:004254233 | Thyroid | ATC | response to hydrogen peroxide | 92/6293 | 146/18723 | 3.12e-13 | 1.46e-11 | 92 |
GO:000756829 | Thyroid | ATC | aging | 166/6293 | 339/18723 | 2.79e-09 | 6.60e-08 | 166 |
GO:003461433 | Thyroid | ATC | cellular response to reactive oxygen species | 87/6293 | 155/18723 | 6.54e-09 | 1.43e-07 | 87 |
GO:0051017210 | Thyroid | ATC | actin filament bundle assembly | 85/6293 | 157/18723 | 8.99e-08 | 1.54e-06 | 85 |
GO:0061572210 | Thyroid | ATC | actin filament bundle organization | 86/6293 | 161/18723 | 1.68e-07 | 2.69e-06 | 86 |
GO:007030122 | Thyroid | ATC | cellular response to hydrogen peroxide | 58/6293 | 98/18723 | 1.81e-07 | 2.86e-06 | 58 |
GO:004814532 | Thyroid | ATC | regulation of fibroblast proliferation | 49/6293 | 80/18723 | 3.73e-07 | 5.48e-06 | 49 |
GO:000756924 | Thyroid | ATC | cell aging | 72/6293 | 132/18723 | 5.77e-07 | 8.15e-06 | 72 |
GO:004814432 | Thyroid | ATC | fibroblast proliferation | 49/6293 | 81/18723 | 6.38e-07 | 8.80e-06 | 49 |
GO:009039814 | Thyroid | ATC | cellular senescence | 49/6293 | 93/18723 | 1.13e-04 | 8.08e-04 | 49 |
GO:003647326 | Thyroid | ATC | cell death in response to oxidative stress | 49/6293 | 95/18723 | 2.23e-04 | 1.46e-03 | 49 |
GO:009034211 | Thyroid | ATC | regulation of cell aging | 33/6293 | 61/18723 | 7.76e-04 | 4.28e-03 | 33 |
GO:000716225 | Thyroid | ATC | negative regulation of cell adhesion | 127/6293 | 303/18723 | 1.45e-03 | 7.47e-03 | 127 |
GO:2000772 | Thyroid | ATC | regulation of cellular senescence | 28/6293 | 53/18723 | 3.01e-03 | 1.36e-02 | 28 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAWR | deletion | Frame_Shift_Del | novel | c.793delN | p.Ser265ValfsTer15 | p.S265Vfs*15 | Q96IZ0 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PAWR | SNV | Missense_Mutation | novel | c.691N>C | p.Ser231Arg | p.S231R | Q96IZ0 | protein_coding | tolerated(0.53) | benign(0.109) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAWR | SNV | Missense_Mutation | novel | c.842N>A | p.Arg281Lys | p.R281K | Q96IZ0 | protein_coding | tolerated(0.66) | benign(0.001) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PAWR | SNV | Missense_Mutation | c.740N>A | p.Ser247Asn | p.S247N | Q96IZ0 | protein_coding | tolerated(0.05) | benign(0.215) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAWR | SNV | Missense_Mutation | c.50N>T | p.Thr17Ile | p.T17I | Q96IZ0 | protein_coding | deleterious(0) | possibly_damaging(0.55) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAWR | SNV | Missense_Mutation | c.920N>C | p.Ile307Thr | p.I307T | Q96IZ0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AF-2690-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PAWR | SNV | Missense_Mutation | rs768593781 | c.728N>A | p.Arg243Gln | p.R243Q | Q96IZ0 | protein_coding | deleterious(0.03) | possibly_damaging(0.836) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PAWR | SNV | Missense_Mutation | novel | c.863G>A | p.Arg288Lys | p.R288K | Q96IZ0 | protein_coding | deleterious(0.04) | benign(0.187) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PAWR | deletion | Frame_Shift_Del | c.809delN | p.Lys270ArgfsTer10 | p.K270Rfs*10 | Q96IZ0 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
PAWR | SNV | Missense_Mutation | novel | c.807A>C | p.Glu269Asp | p.E269D | Q96IZ0 | protein_coding | deleterious(0.02) | possibly_damaging(0.838) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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