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Gene: LGALS9 |
Gene summary for LGALS9 |
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Gene information | Species | Human | Gene symbol | LGALS9 | Gene ID | 3965 |
Gene name | galectin 9 | |
Gene Alias | HUAT | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O00182 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3965 | LGALS9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.04e-10 | 4.39e-01 | 0.0155 |
3965 | LGALS9 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.36e-24 | 9.44e-01 | -0.1808 |
3965 | LGALS9 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.49e-12 | 7.31e-01 | -0.0811 |
3965 | LGALS9 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.39e-08 | 5.97e-01 | -0.1088 |
3965 | LGALS9 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.37e-42 | 1.17e+00 | -0.1954 |
3965 | LGALS9 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.33e-05 | 1.05e+00 | -0.2602 |
3965 | LGALS9 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.91e-02 | 8.52e-01 | -0.2196 |
3965 | LGALS9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.33e-19 | 9.69e-01 | -0.1207 |
3965 | LGALS9 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.10e-13 | 8.24e-01 | -0.1526 |
3965 | LGALS9 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.34e-33 | 8.88e-01 | -0.1464 |
3965 | LGALS9 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.57e-17 | 7.41e-01 | -0.1001 |
3965 | LGALS9 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.71e-25 | 9.18e-01 | -0.059 |
3965 | LGALS9 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.90e-04 | 6.42e-01 | -0.1706 |
3965 | LGALS9 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.07e-07 | 8.28e-01 | -0.1462 |
3965 | LGALS9 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.35e-17 | 1.10e+00 | -0.0842 |
3965 | LGALS9 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.24e-02 | 5.51e-01 | -0.00410000000000005 |
3965 | LGALS9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.53e-03 | 3.63e-01 | -0.0179 |
3965 | LGALS9 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.83e-11 | 3.63e-01 | 0.096 |
3965 | LGALS9 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.70e-03 | 4.08e-01 | 0.0446 |
3965 | LGALS9 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.23e-04 | 1.01e+00 | 0.0451 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007188711 | Thyroid | ATC | leukocyte apoptotic process | 53/6293 | 106/18723 | 3.48e-04 | 2.16e-03 | 53 |
GO:190122421 | Thyroid | ATC | positive regulation of NIK/NF-kappaB signaling | 37/6293 | 69/18723 | 4.80e-04 | 2.81e-03 | 37 |
GO:00509206 | Thyroid | ATC | regulation of chemotaxis | 99/6293 | 223/18723 | 4.91e-04 | 2.86e-03 | 99 |
GO:000269023 | Thyroid | ATC | positive regulation of leukocyte chemotaxis | 47/6293 | 94/18723 | 7.32e-04 | 4.11e-03 | 47 |
GO:007160422 | Thyroid | ATC | transforming growth factor beta production | 25/6293 | 43/18723 | 8.24e-04 | 4.53e-03 | 25 |
GO:007163422 | Thyroid | ATC | regulation of transforming growth factor beta production | 24/6293 | 41/18723 | 9.12e-04 | 4.92e-03 | 24 |
GO:000181924 | Thyroid | ATC | positive regulation of cytokine production | 189/6293 | 467/18723 | 1.00e-03 | 5.31e-03 | 189 |
GO:005109122 | Thyroid | ATC | positive regulation of DNA-binding transcription factor activity | 111/6293 | 260/18723 | 1.32e-03 | 6.88e-03 | 111 |
GO:000716225 | Thyroid | ATC | negative regulation of cell adhesion | 127/6293 | 303/18723 | 1.45e-03 | 7.47e-03 | 127 |
GO:190390221 | Thyroid | ATC | positive regulation of viral life cycle | 18/6293 | 29/18723 | 1.58e-03 | 7.98e-03 | 18 |
GO:000268818 | Thyroid | ATC | regulation of leukocyte chemotaxis | 57/6293 | 122/18723 | 1.77e-03 | 8.71e-03 | 57 |
GO:004508813 | Thyroid | ATC | regulation of innate immune response | 94/6293 | 218/18723 | 2.05e-03 | 9.71e-03 | 94 |
GO:001095033 | Thyroid | ATC | positive regulation of endopeptidase activity | 79/6293 | 179/18723 | 2.09e-03 | 9.86e-03 | 79 |
GO:004390327 | Thyroid | ATC | regulation of biological process involved in symbiotic interaction | 36/6293 | 72/18723 | 2.91e-03 | 1.32e-02 | 36 |
GO:000268519 | Thyroid | ATC | regulation of leukocyte migration | 90/6293 | 210/18723 | 3.11e-03 | 1.40e-02 | 90 |
GO:003806122 | Thyroid | ATC | NIK/NF-kappaB signaling | 64/6293 | 143/18723 | 3.53e-03 | 1.57e-02 | 64 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
GO:00327608 | Thyroid | ATC | positive regulation of tumor necrosis factor production | 48/6293 | 103/18723 | 4.14e-03 | 1.76e-02 | 48 |
GO:20001062 | Thyroid | ATC | regulation of leukocyte apoptotic process | 39/6293 | 81/18723 | 4.65e-03 | 1.92e-02 | 39 |
GO:004328031 | Thyroid | ATC | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 58/6293 | 129/18723 | 4.70e-03 | 1.93e-02 | 58 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | ADJ |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | ADJ |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | DCIS |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | DCIS |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | DCIS |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | Healthy |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | Healthy |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | Healthy |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | IDC |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | IDC |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | IDC |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | ADJ |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | ADJ |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | ADJ |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | CC |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | CC |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | CC |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | Precancer |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | Precancer |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS9 | SNV | Missense_Mutation | novel | c.520C>A | p.Pro174Thr | p.P174T | O00182 | protein_coding | deleterious(0.02) | benign(0.122) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | novel | c.70N>A | p.Gly24Ser | p.G24S | O00182 | protein_coding | tolerated(0.09) | possibly_damaging(0.763) | TCGA-C8-A27A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
LGALS9 | SNV | Missense_Mutation | novel | c.671N>T | p.Pro224Leu | p.P224L | O00182 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | c.25N>T | p.Pro9Ser | p.P9S | O00182 | protein_coding | tolerated(0.08) | benign(0.035) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LGALS9 | SNV | Missense_Mutation | novel | c.595N>G | p.Thr199Ala | p.T199A | O00182 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | rs147965169 | c.812N>A | p.Arg271His | p.R271H | O00182 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | novel | c.217G>A | p.Val73Met | p.V73M | O00182 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
LGALS9 | SNV | Missense_Mutation | c.827C>T | p.Ala276Val | p.A276V | O00182 | protein_coding | tolerated(0.26) | benign(0.161) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS9 | SNV | Missense_Mutation | rs147965169 | c.812N>A | p.Arg271His | p.R271H | O00182 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | rs753232858 | c.274C>A | p.Pro92Thr | p.P92T | O00182 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3965 | LGALS9 | DRUGGABLE GENOME, TRANSPORTER | LACTOSE, ANHYDROUS | LACTOSE, ANHYDROUS | 21524586 |
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