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Gene: GOLPH3 |
Gene summary for GOLPH3 |
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Gene information | Species | Human | Gene symbol | GOLPH3 | Gene ID | 64083 |
Gene name | golgi phosphoprotein 3 | |
Gene Alias | GOPP1 | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9H4A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64083 | GOLPH3 | CCI_1 | Human | Cervix | CC | 4.95e-04 | 6.57e-01 | 0.528 |
64083 | GOLPH3 | CCI_3 | Human | Cervix | CC | 1.07e-06 | 6.50e-01 | 0.516 |
64083 | GOLPH3 | sample3 | Human | Cervix | CC | 1.15e-07 | 2.51e-01 | 0.1387 |
64083 | GOLPH3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.71e-14 | -5.18e-01 | 0.0155 |
64083 | GOLPH3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.81e-03 | -2.31e-01 | -0.1464 |
64083 | GOLPH3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.72e-07 | -3.28e-01 | 0.0674 |
64083 | GOLPH3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.28e-13 | -4.22e-01 | 0.3005 |
64083 | GOLPH3 | F007 | Human | Colorectum | FAP | 4.72e-03 | -3.21e-01 | 0.1176 |
64083 | GOLPH3 | A002-C-010 | Human | Colorectum | FAP | 1.15e-03 | -1.55e-01 | 0.242 |
64083 | GOLPH3 | A015-C-203 | Human | Colorectum | FAP | 9.00e-29 | -3.47e-01 | -0.1294 |
64083 | GOLPH3 | A015-C-204 | Human | Colorectum | FAP | 3.74e-05 | -2.24e-01 | -0.0228 |
64083 | GOLPH3 | A014-C-040 | Human | Colorectum | FAP | 1.10e-05 | -4.38e-01 | -0.1184 |
64083 | GOLPH3 | A002-C-201 | Human | Colorectum | FAP | 1.52e-13 | -2.97e-01 | 0.0324 |
64083 | GOLPH3 | A002-C-203 | Human | Colorectum | FAP | 1.93e-07 | -1.98e-01 | 0.2786 |
64083 | GOLPH3 | A001-C-119 | Human | Colorectum | FAP | 3.06e-08 | -2.82e-01 | -0.1557 |
64083 | GOLPH3 | A001-C-108 | Human | Colorectum | FAP | 7.58e-18 | -3.17e-01 | -0.0272 |
64083 | GOLPH3 | A002-C-205 | Human | Colorectum | FAP | 1.25e-19 | -2.78e-01 | -0.1236 |
64083 | GOLPH3 | A014-C-108 | Human | Colorectum | FAP | 1.38e-02 | -3.39e-01 | -0.124 |
64083 | GOLPH3 | A001-C-104 | Human | Colorectum | FAP | 1.06e-08 | -2.88e-01 | 0.0184 |
64083 | GOLPH3 | A015-C-006 | Human | Colorectum | FAP | 1.90e-14 | -4.55e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005122227 | Thyroid | HT | positive regulation of protein transport | 38/1272 | 303/18723 | 1.90e-04 | 2.78e-03 | 38 |
GO:007265927 | Thyroid | HT | protein localization to plasma membrane | 36/1272 | 284/18723 | 2.24e-04 | 3.20e-03 | 36 |
GO:009730527 | Thyroid | HT | response to alcohol | 33/1272 | 253/18723 | 2.37e-04 | 3.34e-03 | 33 |
GO:199077825 | Thyroid | HT | protein localization to cell periphery | 39/1272 | 333/18723 | 6.29e-04 | 7.21e-03 | 39 |
GO:000690026 | Thyroid | HT | vesicle budding from membrane | 12/1272 | 61/18723 | 7.13e-04 | 8.03e-03 | 12 |
GO:000716328 | Thyroid | HT | establishment or maintenance of cell polarity | 28/1272 | 218/18723 | 8.66e-04 | 9.20e-03 | 28 |
GO:005090017 | Thyroid | HT | leukocyte migration | 41/1272 | 369/18723 | 1.31e-03 | 1.26e-02 | 41 |
GO:005165129 | Thyroid | HT | maintenance of location in cell | 27/1272 | 214/18723 | 1.39e-03 | 1.32e-02 | 27 |
GO:001605016 | Thyroid | HT | vesicle organization | 33/1272 | 300/18723 | 4.30e-03 | 3.13e-02 | 33 |
GO:005123528 | Thyroid | HT | maintenance of location | 35/1272 | 327/18723 | 5.16e-03 | 3.47e-02 | 35 |
GO:19016558 | Thyroid | HT | cellular response to ketone | 14/1272 | 96/18723 | 5.28e-03 | 3.50e-02 | 14 |
GO:006195116 | Thyroid | HT | establishment of protein localization to plasma membrane | 10/1272 | 60/18723 | 6.77e-03 | 4.17e-02 | 10 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:1904951113 | Thyroid | PTC | positive regulation of establishment of protein localization | 175/5968 | 319/18723 | 1.10e-17 | 1.12e-15 | 175 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:001605017 | Thyroid | PTC | vesicle organization | 163/5968 | 300/18723 | 4.74e-16 | 3.69e-14 | 163 |
GO:0051222113 | Thyroid | PTC | positive regulation of protein transport | 163/5968 | 303/18723 | 1.58e-15 | 1.16e-13 | 163 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:0045185113 | Thyroid | PTC | maintenance of protein location | 64/5968 | 94/18723 | 5.92e-13 | 2.85e-11 | 64 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLPH3 | SNV | Missense_Mutation | c.255N>G | p.Ile85Met | p.I85M | Q9H4A6 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AR-A1AS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
GOLPH3 | SNV | Missense_Mutation | c.769N>G | p.Leu257Val | p.L257V | Q9H4A6 | protein_coding | tolerated(0.29) | benign(0.033) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
GOLPH3 | insertion | Frame_Shift_Ins | novel | c.562_563insAACCAGAAGT | p.Thr188LysfsTer14 | p.T188Kfs*14 | Q9H4A6 | protein_coding | TCGA-BH-A0H0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
GOLPH3 | insertion | Frame_Shift_Ins | novel | c.573_574insTTCTC | p.Gln192PhefsTer10 | p.Q192Ffs*10 | Q9H4A6 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
GOLPH3 | SNV | Missense_Mutation | rs192633198 | c.704G>A | p.Arg235His | p.R235H | Q9H4A6 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GOLPH3 | SNV | Missense_Mutation | c.311N>C | p.Gln104Pro | p.Q104P | Q9H4A6 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GOLPH3 | SNV | Missense_Mutation | c.394N>G | p.Leu132Val | p.L132V | Q9H4A6 | protein_coding | deleterious(0.02) | benign(0.193) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
GOLPH3 | SNV | Missense_Mutation | rs773095936 | c.520N>T | p.Arg174Trp | p.R174W | Q9H4A6 | protein_coding | deleterious(0.02) | benign(0.214) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GOLPH3 | SNV | Missense_Mutation | c.527N>A | p.Arg176Gln | p.R176Q | Q9H4A6 | protein_coding | deleterious(0) | benign(0.332) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
GOLPH3 | SNV | Missense_Mutation | novel | c.502T>C | p.Tyr168His | p.Y168H | Q9H4A6 | protein_coding | tolerated(0.06) | benign(0.251) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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